Dexamethasone in the Last Week of Pregnancy Attenuates Hippocampal Glucocorticoid Receptor Gene Expression and Elevates Blood Pressure in the Adult Offspring in the Rat

1996 ◽  
Vol 64 (6) ◽  
pp. 412-418 ◽  
Author(s):  
Naomi S. Levitt ◽  
Robert S. Lindsay ◽  
Megan C. Holmes ◽  
Jonathan R. Seckl
Keyword(s):  
Gene Expression ◽  
Blood Pressure ◽  
Glucocorticoid Receptor ◽  
Receptor Gene ◽  
Adult Offspring ◽  
Glucocorticoid Receptor Gene ◽  
Receptor Gene Expression

Lower glucocorticoid receptor gene expression and glucocorticoid receptor variants are associated with cocaine use and addiction

2017 ◽  
Vol 83 ◽  
pp. 81 ◽  
Author(s):  
Andrea B. Schote ◽  
Kristina Jäger ◽  
Sara L. Kroll ◽  
Matthias Vonmoos ◽  
Lea M. Hulka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Glucocorticoid Receptor ◽  
Receptor Gene ◽  
Cocaine Use ◽  
Glucocorticoid Receptor Gene ◽  
Receptor Gene Expression

No evidence for HPA reset in adult sheep with high blood pressure due to short prenatal exposure to dexamethasone

2002 ◽  
Vol 282 (2) ◽  
pp. R343-R350 ◽  
Author(s):  
Miodrag Dodic ◽  
Arianne Peers ◽  
Karen Moritz ◽  
Vicky Hantzis ◽  
E. Marelyn Wintour
Keyword(s):  
Gene Expression ◽  
Blood Pressure ◽  
High Blood Pressure ◽  
Hpa Axis ◽  
Receptor Gene ◽  
Adult Offspring ◽  
Significant Difference ◽  
Group D ◽  
Receptor Gene Expression ◽  
Concentration Curves

Exposure of pregnant ewes to dexamethasone, for only 2 days (term ∼150 days) at 27 days of gestation ( group D), results in adult offspring with high blood pressure. In this study, hemorrhage stress has been used to see whether in these animals the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis is altered. In addition, we studied mineralocorticoid (MR) and glucocorticoid (GR) receptor gene expression in the hippocampus and GR gene expression in the hypothalamus using real-time PCR. Calculated areas under the adrenocorticotropin, arginine vasopressin, and cortisol plasma concentration curves in response to hemorrhage were similar between the control and group D. In addition, there was no significant difference in the expression of MR and GR in the hippocampus or GR in the hypothalamus between the control and group D. Taken together, it is unlikely that reset in the HPA axis plays a major role in this particular model of “programmed” hypertension.

Glucocorticoid receptor gene expression and promoter CpG modifications throughout the human brain

2013 ◽  
Vol 47 (11) ◽  
pp. 1597-1607 ◽  
Author(s):  
Lei Cao-Lei ◽  
Songkiet Suwansirikul ◽  
Prapan Jutavijittum ◽  
Sophie B. Mériaux ◽  
Jonathan D. Turner ◽  
...  
Keyword(s):  
Gene Expression ◽  
Glucocorticoid Receptor ◽  
Human Brain ◽  
Receptor Gene ◽  
Glucocorticoid Receptor Gene ◽  
Receptor Gene Expression
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