Ligand-Controlled Interaction of Histone Acetyltransferase Binding to ORC-1 (HBO1) with the N-Terminal Transactivating Domain of Progesterone Receptor Induces Steroid Receptor Coactivator 1-Dependent Coactivation of Transcription

2006 ◽  
Vol 20 (9) ◽  
pp. 2122-2140 ◽  
Author(s):  
Maria Georgiakaki ◽  
Nathalie Chabbert-Buffet ◽  
Boris Dasen ◽  
Geri Meduri ◽  
Sandra Wenk ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Histone Acetyltransferase ◽  
Steroid Receptor ◽  
Steroid Receptor Coactivator

scholarly journals Steroid Receptor Coactivator (SRC)-1 and SRC-3 Differentially Modulate Tissue-Specific Activation Functions of the Progesterone Receptor

2006 ◽  
Vol 20 (1) ◽  
pp. 45-55 ◽  
Author(s):  
Sang Jun Han ◽  
Francesco J. DeMayo ◽  
Jianming Xu ◽  
Sophia Y. Tsai ◽  
Ming-Jer Tsai ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Steroid Receptor ◽  
Activation Functions ◽  
Tissue Specific ◽  
Steroid Receptor Coactivator

scholarly journals Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus†

2020 ◽  
Vol 103 (4) ◽  
pp. 760-768
Author(s):  
Ryan M Marquardt ◽  
Kevin Lee ◽  
Tae Hoon Kim ◽  
Brandon Lee ◽  
Francesco J DeMayo ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Steroid Hormones ◽  
Early Pregnancy ◽  
Stromal Cells ◽  
Knockout Mice ◽  
Steroid Receptor ◽  
Receptor Subunit ◽  
Ovarian Steroid ◽  
Endometrial Stromal Cells ◽  
Steroid Receptor Coactivator

Abstract The endometrium, composed of epithelial and stromal cell compartments, is tightly regulated by the ovarian steroid hormones estrogen (E2) and progesterone (P4) during early pregnancy. Through the progesterone receptor (PGR), steroid receptor coactivators, and other transcriptional coregulators, progesterone inhibits E2-induced cell proliferation and induces the differentiation of stromal cells in a process called decidualization to promote endometrial receptivity. Although interleukin-13 receptor subunit alpha-2 (Il13ra2) is expressed in the human and mouse endometrium, its potential role in the steroid hormone regulation of the endometrium has not been thoroughly examined. In this study, we employed PGR knockout mice and steroid receptor coactivator-1 knockout mice (SRC-1−/−) to profile the expression of Il13ra2 in the murine endometrium and determine the role of these transcriptional regulators in the hormone-responsiveness of Il13ra2 expression. Furthermore, we utilized a well-established decidualization-inducing steroidogenic cocktail and a siRNA-based knockdown of IL13RA2 to determine the importance of IL13RA2 in the decidualization of primary human endometrial stromal cells. Our findings demonstrate that Il13ra2 is expressed in the subepithelial stroma of the murine endometrium in response to ovarian steroid hormones and during early pregnancy in a PGR- and SRC-1-dependent manner. Furthermore, we show that knockdown of IL13RA2 before in vitro decidualization of primary human endometrial stromal cells partially compromises the full decidualization response. We conclude that Il13ra2 is a downstream target of progesterone through PGR and SRC-1 and plays a role in mediating the stromal action of ovarian steroid hormones.

scholarly journals Progesterone Receptor Coregulators as Factors Supporting the Function of the Corpus Luteum in Cows

Genes ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 923
Author(s):  
Robert Rekawiecki ◽  
Karolina Dobrzyn ◽  
Jan Kotwica ◽  
Magdalena K. Kowalik
Keyword(s):  
Progesterone Receptor ◽  
Corpus Luteum ◽  
Estrous Cycle ◽  
Histone Acetyltransferase ◽  
Camp Response Element Binding ◽  
Target Cells ◽  
Expression Levels ◽  
Steroid Receptor Coactivator ◽  
Element Binding Protein ◽  
Coregulatory Proteins

Progesterone receptor (PGR) for its action required connection of the coregulatory proteins, including coactivators and corepressors. The former group exhibits a histone acetyltransferase (HAT) activity, while the latter cooperates with histone deacetylase (HDAC). Regulations of the coregulators mRNA and protein and HAT and HDAC activity can have an indirect effect on the PGR function and thus progesterone (P4) action on target cells. The highest mRNA expression levels for the coactivators—histone acetyltransferase p300 (P300), cAMP response element-binding protein (CREB), and steroid receptor coactivator-1 (SRC-1)—and nuclear receptor corepressor-2 (NCOR-2) were found in the corpus luteum (CL) on days 6 to 16 of the estrous cycle. The CREB protein level was higher on days 2–10, whereas SRC-1 and NCOR-2 were higher on days 2–5. The activity of HAT and HDAC was higher on days 6–10 of the estrous cycle. All of the coregulators were localized in the nuclei of small and large luteal cells. The mRNA and protein expression levels of the examined coactivators and corepressor changed with the P4 level. Thus, P4 may regulate CL function via the expression of coregulators, which probably affects the activity of the PGR.

Steroid receptor coactivator-1 is a histone acetyltransferase

Nature ◽  
10.1038/38304 ◽  
1997 ◽  
Vol 389 (6647) ◽  
pp. 194-198 ◽  
Author(s):  
Thomas E. Spencer ◽  
Guido Jenster ◽  
Mark M. Burcin ◽  
C. David Allis ◽  
Jianxin Zhou ◽  
...  
Keyword(s):  
Histone Acetyltransferase ◽  
Steroid Receptor ◽  
Steroid Receptor Coactivator

scholarly journals Sumoylation of the Progesterone Receptor and of the Steroid Receptor Coactivator SRC-1

2003 ◽  
Vol 278 (14) ◽  
pp. 12335-12343 ◽  
Author(s):  
Anne Chauchereau ◽  
Larbi Amazit ◽  
Monique Quesne ◽  
Anne Guiochon-Mantel ◽  
Edwin Milgrom
Keyword(s):  
Progesterone Receptor ◽  
Steroid Receptor ◽  
Steroid Receptor Coactivator
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