scholarly journals Sumoylation of the Progesterone Receptor and of the Steroid Receptor Coactivator SRC-1

2003 ◽  
Vol 278 (14) ◽  
pp. 12335-12343 ◽  
Author(s):  
Anne Chauchereau ◽  
Larbi Amazit ◽  
Monique Quesne ◽  
Anne Guiochon-Mantel ◽  
Edwin Milgrom
Keyword(s):  
Progesterone Receptor ◽  
Steroid Receptor ◽  
Steroid Receptor Coactivator

scholarly journals Steroid Receptor Coactivator (SRC)-1 and SRC-3 Differentially Modulate Tissue-Specific Activation Functions of the Progesterone Receptor

2006 ◽  
Vol 20 (1) ◽  
pp. 45-55 ◽  
Author(s):  
Sang Jun Han ◽  
Francesco J. DeMayo ◽  
Jianming Xu ◽  
Sophia Y. Tsai ◽  
Ming-Jer Tsai ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Steroid Receptor ◽  
Activation Functions ◽  
Tissue Specific ◽  
Steroid Receptor Coactivator

scholarly journals Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus†

2020 ◽  
Vol 103 (4) ◽  
pp. 760-768
Author(s):  
Ryan M Marquardt ◽  
Kevin Lee ◽  
Tae Hoon Kim ◽  
Brandon Lee ◽  
Francesco J DeMayo ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Steroid Hormones ◽  
Early Pregnancy ◽  
Stromal Cells ◽  
Knockout Mice ◽  
Steroid Receptor ◽  
Receptor Subunit ◽  
Ovarian Steroid ◽  
Endometrial Stromal Cells ◽  
Steroid Receptor Coactivator

Abstract The endometrium, composed of epithelial and stromal cell compartments, is tightly regulated by the ovarian steroid hormones estrogen (E2) and progesterone (P4) during early pregnancy. Through the progesterone receptor (PGR), steroid receptor coactivators, and other transcriptional coregulators, progesterone inhibits E2-induced cell proliferation and induces the differentiation of stromal cells in a process called decidualization to promote endometrial receptivity. Although interleukin-13 receptor subunit alpha-2 (Il13ra2) is expressed in the human and mouse endometrium, its potential role in the steroid hormone regulation of the endometrium has not been thoroughly examined. In this study, we employed PGR knockout mice and steroid receptor coactivator-1 knockout mice (SRC-1−/−) to profile the expression of Il13ra2 in the murine endometrium and determine the role of these transcriptional regulators in the hormone-responsiveness of Il13ra2 expression. Furthermore, we utilized a well-established decidualization-inducing steroidogenic cocktail and a siRNA-based knockdown of IL13RA2 to determine the importance of IL13RA2 in the decidualization of primary human endometrial stromal cells. Our findings demonstrate that Il13ra2 is expressed in the subepithelial stroma of the murine endometrium in response to ovarian steroid hormones and during early pregnancy in a PGR- and SRC-1-dependent manner. Furthermore, we show that knockdown of IL13RA2 before in vitro decidualization of primary human endometrial stromal cells partially compromises the full decidualization response. We conclude that Il13ra2 is a downstream target of progesterone through PGR and SRC-1 and plays a role in mediating the stromal action of ovarian steroid hormones.

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