scholarly journals Two Tandemly Linked Interferon-γ-Activated Sequence Elements in the Promoter of Glycosylation-Dependent Cell Adhesion Molecule 1 Gene Synergistically Respond to Prolactin in Mouse Mammary Epithelial Cells

2003 ◽  
Vol 17 (10) ◽  
pp. 1910-1920 ◽  
Author(s):  
Zhaoyuan Hou ◽  
Sunil Srivastava ◽  
Meenakshi J. Mistry ◽  
Matthew P. Herbst ◽  
Jason P. Bailey ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cells ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Mammary Epithelial Cells ◽  
Interferon Γ ◽  
Mammary Epithelial ◽  
Sequence Elements ◽  
Dependent Cell ◽  
Cell Adhesion Molecule 1

scholarly journals Affinity and Kinetic Analysis of L-selectin (CD62L) Binding to Glycosylation-dependent Cell-adhesion Molecule-1

1998 ◽  
Vol 273 (2) ◽  
pp. 763-770 ◽  
Author(s):  
Martin W. Nicholson ◽  
A. Neil Barclay ◽  
Mark S. Singer ◽  
Steven D. Rosen ◽  
P. Anton van der Merwe
Keyword(s):  
Cell Adhesion ◽  
Kinetic Analysis ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Dependent Cell ◽  
Cell Adhesion Molecule 1

scholarly journals Vascular Cell Adhesion Molecule-1 Is Expressed by Cortical Thymic Epithelial Cells and Mediates Thymocyte Adhesion. Implications for the Function of α4β1 (VLA4) Integrin in T-Cell Development

Blood ◽  
1997 ◽  
Vol 89 (7) ◽  
pp. 2461-2471 ◽  
Author(s):  
Daniel R. Salomon ◽  
Laura Crisa ◽  
Christopher F. Mojcik ◽  
Jennifer K. Ishii ◽  
George Klier ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
T Cell ◽  
Epithelial Cells ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
T Cell Development ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Cell Adhesion Molecule 1

Abstract T-cell development requires a series of discrete selection and activation signals delivered to maturing progenitors in the thymic cortex and medulla. We have previously shown the constitutive activity of the integrin, α4β1 (VLA4), on a unique subpopulation of immature cortical thymocytes and proposed a role for integrin-mediated adhesion in positive selection by cortical epithelium. In the present report we show that thymic epithelial cell lines express vascular cell adhesion molecule-1 (VCAM-1) a high-affinity ligand for α4β1, and that VCAM-1 mediates thymocyte binding to these lines. Immunohistochemistry and confocal microscopy show that VCAM-1 is selectively expressed in situ by thymic epithelium in the cortex and corticomedullary junction, two locations at which VCAM-1 could determine the interaction between immature thymocytes and selecting elements on epithelial cells. In parallel, we confirmed that fibronectin (FN), the alternative ligand for α4β1, is expressed predominantly in the medulla. These results suggest that VCAM-1 is an adhesive ligand in the thymic cortex for the activated form of α4β1 constitutively expressed during development by immature double positive thymocytes. The structural segregation of the alternative ligand, FN, to the medulla suggests that medullary FN may regulate the migration, development, and export of more mature thymocytes.

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