scholarly journals Persistent Poor Metabolic Profile in Postmenopausal Women With Ovarian Hyperandrogenism After Testosterone Level Normalization

2019 ◽  
Vol 3 (5) ◽  
pp. 1087-1096 ◽  
Author(s):  
Thaís Rocha ◽  
Raiane P Crespo ◽  
Viviane V R Yance ◽  
Sylvia A Hayashida ◽  
Edmund C Baracat ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Testosterone Level ◽  
Metabolic Profile ◽  
Ovarian Hyperandrogenism

Effects of a weight loss program on body composition and the metabolic profile in obese postmenopausal women displaying various obesity phenotypes: a MONET group study

2015 ◽  
Vol 40 (7) ◽  
pp. 695-702 ◽  
Author(s):  
Eve Normandin ◽  
Eric Doucet ◽  
Rémi Rabasa-Lhoret ◽  
Martin Brochu
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Postmenopausal Women ◽  
Body Fat ◽  
Metabolic Profile ◽  
Fat Distribution ◽  
Weight Loss Program ◽  
Glucose Disposal ◽  
Fasting Insulin ◽  
Secondary Analyses

Obesity is a heterogeneous condition, since the metabolic profile may differ greatly from one individual to another. The objective of this study was to compare the effect of a 6-month diet-induced weight loss program on body composition and the metabolic profile in obese individuals displaying different obesity phenotypes. Secondary analyses were done on 129 obese (% body fat: 46% ± 4%) postmenopausal women (age: 57 ± 4 years). Outcome measures included body composition, body fat distribution, glucose homeostasis, fasting lipids, and blood pressure. Obesity phenotypes were determined based on lean body mass (LBM) index (LBMI = LBM/height2) and visceral fat (VF) accumulation, as follows: 1, lower VF and lower LBMI (n = 35); 2, lower VF and higher LBMI (n = 19); 3, higher VF and lower LBMI (n = 14); and 4, higher VF and higher LBMI (n = 61). All groups had significantly improved measures of body composition after the intervention (P < 0.0001). Greater decreases in LBM and LBMI were observed in the higher LBMI groups than in the lower LBMI groups (P < 0.0001). Similarly, decreases in VF were greater in the higher VF groups than in the lower VF groups (P < 0.05). Overall, fasting insulin levels and glucose disposal improved following the intervention, with higher LBMI groups showing a trend for greater improvements (P = 0.06 and 0.07, respectively). Overall, no difference was observed among the different obesity phenotypes regarding improvements in the metabolic profile in response to weight loss. Individuals displaying higher VF or higher LBMI at baseline experienced significantly greater decreases for these variables after the intervention.

Acute and short-term effects of caloric restriction on metabolic profile and brain activation in obese, postmenopausal women

2016 ◽  
Vol 40 (11) ◽  
pp. 1671-1678 ◽  
Author(s):  
S Jakobsdottir ◽  
I C van Nieuwpoort ◽  
C C van Bunderen ◽  
M B de Ruiter ◽  
J W R Twisk ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Caloric Restriction ◽  
Metabolic Profile ◽  
Brain Activation ◽  
Short Term ◽  
Short Term Effects

scholarly journals Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Reza Rezvani ◽  
Jessica Smith ◽  
Marc Lapointe ◽  
Picard Marceau ◽  
Andre Tchernof ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Metabolic Profile ◽  
Liver Enzymes ◽  
Weight Loss Surgery ◽  
Complement C3 ◽  
Enzyme Analysis ◽  
Low Grade ◽  
Obese Women ◽  
Hepatic Expression ◽  
Mrna Ratio

Objective. Obesity is associated with metabolic dysfunction with sex differences and chronic, low-grade inflammation. We proposed that hepatic expression of immune complement C3 related receptors (C3aR, C5aR, and C5L2) would be associated with pre- or postmenopausal status and metabolic profile in severely obese women. We hypothesized that C5L2/C5aR ratio, potentially influencing the ASP/C5L2 metabolic versus C5a/C5aR immune response, would predict metabolic profiles after weight loss surgery.Materials and Methods. Fasting plasma (hormone, lipid, and enzyme analysis) and liver biopsies (RT-PCR gene expression) were obtained from 91 women during surgery.Results. Hepatic C5L2 mRNA expression was elevated in pre- versus postmenopausal women (P<0.01) and correlated positively with circulating estradiol, estrone, ApoB, ApoA1, ApoA1/B, waist circumference, age, and LDL-C (allP<0.05). While plasma ASP was lower in pre- versus postmenopausal women (P<0.01), the hepatic C5L2/C5aR mRNA ratio was increased (P<0.001) and correlated positively with estrone (P<0.01) and estradiol (P<0.001) and negatively with circulating ApoB and liver enzymes ALT, AST, and GGT (allP<0.05). Over 12 months postoperatively, liver enzymes in low C5L2/C5aR mRNA ratio group remained higher (ALP and ALT,P<0.05, AST and GGT,P<0.0012-way-ANOVA).Conclusion. C5L2-C5aR association with other mediators including estrogens may contribute to hepatic metabolic and inflammatory function.

Estrogen treatment improves arterial distensibility, fibrinolysis, and metabolic profile in postmenopausal women with type 2 diabetes mellitus

Metabolism ◽  
2006 ◽  
Vol 55 (7) ◽  
pp. 953-959 ◽  
Author(s):  
Claudia Sztejnsznajd ◽  
Maria Elizabeth Rossi da Silva ◽  
Amit Nussbacher ◽  
Otavio Eluf Gebara ◽  
Elbio Antônio D'Ámico ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Postmenopausal Women ◽  
Metabolic Profile ◽  
Estrogen Treatment ◽  
Arterial Distensibility

Effects of phototherapy plus physical training on metabolic profile and quality of life in postmenopausal women

2017 ◽  
Vol 19 (6) ◽  
pp. 364-372 ◽  
Author(s):  
Fernanda Rossi Paolillo ◽  
Audrey Borghi-Silva ◽  
Ross Arena ◽  
Nivaldo Antonio Parizotto ◽  
Cristina Kurachi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Postmenopausal Women ◽  
Physical Training ◽  
Metabolic Profile

Short-term program of aerobic training prescribed using critical velocity is effective to improve metabolic profile in postmenopausal women

2016 ◽  
Vol 31 (2) ◽  
pp. 95-102 ◽  
Author(s):  
T.A. Diniz ◽  
A.C.S. Fortaleza ◽  
F.E. Rossi ◽  
L.M. Neves ◽  
E.Z. Campos ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Critical Velocity ◽  
Metabolic Profile ◽  
Aerobic Training ◽  
Short Term
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