Serum Testosterone Level Within Normal Range Is Positively Associated with Nonalcoholic Fatty Liver Disease in Premenopausal but Not Postmenopausal Women

2019 ◽  
Vol 28 (8) ◽  
pp. 1077-1082 ◽  
Author(s):  
Jae-Min Park ◽  
Hye Sun Lee ◽  
Joowon Oh ◽  
Yong-Jae Lee
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Postmenopausal Women ◽  
Testosterone Level ◽  
Fatty Liver Disease ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Normal Range ◽  
Nonalcoholic Fatty Liver

Evaluation of Clinical and Inflammatory Markers of Nonalcoholic Fatty Liver Disease in Postmenopausal Women with Metabolic Syndrome

2014 ◽  
Vol 12 (6) ◽  
pp. 330-338 ◽  
Author(s):  
Marcio Hipolito Rodrigues ◽  
Anderson Souza Bruno ◽  
Jorge Nahas-Neto ◽  
Valeria C. Sandrim ◽  
Ludmila G. Muniz ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Postmenopausal Women ◽  
Inflammatory Markers ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

scholarly journals Prevalence of Metabolic Syndrome and Nonalcoholic Fatty Liver Disease among Premenopausal and Postmenopausal Women in Ho Municipality: A Cross-Sectional Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Anita Mawuse Setroame ◽  
Patrick Kormla Affrim ◽  
Albert Abaka-Yawson ◽  
Precious Kwablah Kwadzokpui ◽  
Felicia Eyram Adrah ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Postmenopausal Women ◽  
Abdominal Obesity ◽  
Fatty Liver Disease ◽  
Premenopausal Women ◽  
Nonalcoholic Fatty Liver

Background and Objectives. The prevalence of the metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. MetS-affected individuals stand the risk of coronary heart disease, stroke, and increased cardiovascular mortality while NAFLD results in advanced liver diseases, such as liver fibrosis, cirrhosis, and hepatocellular carcinoma, if not diagnosed and treated on time. This study is aimed at determining the prevalence of MetS and NAFLD among premenopausal and postmenopausal women in Ho Municipality. Methods. A cross-sectional study was conducted among 185 participants: 88 premenopausal and 97 postmenopausal women obtaining healthcare service from Ho Teaching Hospital (HTH) and Ho Municipal Hospital from November 2018 to January 2020. Questionnaires were administered, and direct anthropometric measurements were taken. Blood samples were collected between 8:00 am and 10:00 am after overnight fast (12 to 18 hours; ≥8 hours) to assess fasting blood glucose, fasting lipids, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) concentrations at HTH laboratory using standard measuring procedures. This study in diagnosing metabolic syndrome and nonalcoholic fatty liver disease employed the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) criteria and the Bedogni fatty liver index algorithm, respectively. Results. The overall prevalence of MetS and NAFLD was 24.86% and 40.00% using NCEP-ATPIII and Bedogni fatty liver index algorithm, respectively. The prevalence of MetS and NAFLD among postmenopausal women was 32.99% and 49.48%, respectively, higher than 15.91% and 29.55%, respectively, observed among premenopausal women. The most prevalent MetS component among the study population was abdominal obesity (68.65%) which was significantly higher among the postmenopausal women (82.47%) than premenopausal women (53.41%) (<0.001). Hyperglycemia and hypertension were the major significant risk factors for developing MetS among premenopausal women whereas high triglyceride was the highest risk factor found among the postmenopausal women. Obesity and abdominal obesity were the most likely risk factors for developing nonalcoholic fatty liver disease among both premenopausal and postmenopausal women. Comorbidities of MetS and NAFLD were significant risk factors for developing cardiovascular diseases (CVD) (OR=5.2, 95%CI=2.2-12.4; p<0.001). Conclusion. This study established a significant association between coronary artery disease and comorbidities of MetS and NAFLD among the studied participants. Both conditions were found to be more prevalent among postmenopausal women compared to premenopausal women. Abdominal obesity was the most prevalent MetS component among the population. Women should be monitored for the two conditions and be educated on adopting healthy lifestyles to minimize the incidence of these conditions.

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