Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushing's disease before and after surgical cure

1994 ◽  
Vol 78 (1) ◽  
pp. 131-137 ◽  
Author(s):  
M. A. Magiakou
Keyword(s):  
Growth Hormone ◽  
Cushing’S Disease ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Cushing's Disease ◽  
Before And After ◽  
Surgical Cure

Successful treatment of childhood-onset Cushing's disease is associated with persistent reduction in growth hormone secretion

2004 ◽  
Vol 60 (2) ◽  
pp. 169-174 ◽  
Author(s):  
P. V. Carroll ◽  
J. P. Monson ◽  
A. B. Grossman ◽  
G. M. Besser ◽  
P. N. Plowman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Successful Treatment ◽  
Cushing’S Disease ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Cushing's Disease ◽  
Childhood Onset

scholarly journals Growth and growth hormone secretion in paediatric Cushing's disease

HORMONES ◽  
2003 ◽  
Vol 2 (2) ◽  
pp. 93-97 ◽  
Author(s):  
Martin Savage ◽  
Helen Storr ◽  
Ashley Grossman ◽  
Gerasimos Krassas
Keyword(s):  
Growth Hormone ◽  
Cushing’S Disease ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Cushing's Disease

The recovery of the hypothalamo-pituitary-ad renal axis after transsphenoidal operation in three patients with Cushing's disease. The effect of prior external pituitary irradiation

1981 ◽  
Vol 98 (4) ◽  
pp. 580-585 ◽  
Author(s):  
Steven W.J. Lamberts ◽  
Jan G. M. Klijn ◽  
Frank H. de Jong ◽  
Jan C. Birkenhäger
Keyword(s):  
Growth Hormone ◽  
Cushing’S Disease ◽  
Plasma Cortisol ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Cushing's Disease ◽  
Plasma Acth ◽  
Basal Plasma ◽  
Pituitary Irradiation ◽  
Pituitary Adrenal Axis

Abstract. The recovery of the hypothalamo-pituitary-adrenal axis after selective transsphenoidal adenomectomy was studied in 3 patients with Cushing's disease by measuring basal plasma ACTH and cortisol concentrations, cortisol secretion rate, the diurnal rhythm of cortisol, and the reaction of cortisol to lysine vasopressin (LVP), of compound S to metyrapone and of cortisol and growth hormone to an insulin-induced hypoglycaemia. The third patient had been treated previously by external pituitary irradiation. In 2 patients basal plasma ACTH levels returned within normal values before plasma cortisol, but no supra-physiological plasma concentrations of ACTH were seen as has been observed after withdrawal of exogenous glucocorticoids. With regard to the different stimulation tests: at first the normal reaction of plasma cortisol to LVP returned after 3 months, at the same time as the restoration of growth hormone secretion in response to hypoglycaemia. A normalization of the reaction to metyrapone was seen thereafter while finally the reaction of cortisol to an insulin-induced hypoglycaemia and the diurnal rhythm of plasma cortisol returned 15 to 18 months after operation in the first patient and after 12 months in the second patient. Selective adenomectomy had also been carried out in the third patient, as evidenced by normal TSH, LH and FSH secretion. Hypocortisolism, and a deficient ACTH and growth hormone secretion in response to the stimuli mentioned, however, did not normalize up till 22 months after operation. The restoration of the hypothalamo-pituitary-adrenal axis after selective pituitary adenomectomy in Cushing's disease was prevented in this patient by prior external pituitary irradiation.

A FUNDAMENTAL DEFECT OF ADRENOCORTICAL CONTROL IN CUSHING'S DISEASE

1968 ◽  
Vol 40 (1) ◽  
pp. 15-28 ◽  
Author(s):  
V. H. T. JAMES ◽  
J. LANDON ◽  
V. WYNN ◽  
F. C. GREENWOOD
Keyword(s):  
Growth Hormone ◽  
Cushing’S Disease ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Growth ◽  
Cushing's Disease ◽  
Similar Degree ◽  
Primary Defect ◽  
Harvey Cushing ◽  
Adrenal Response

SUMMARY The plasma sugar, 11-hydroxycorticosteroid, and growth hormone responses to insulin have been studied in patients with Cushing's disease. They showed an impaired or absent plasma 11-hydroxycorticosteroid and growth hormone rise during the test, as compared with control subjects, despite the injection of amounts of insulin which produced a similar degree of hypoglycaemia. This test proved of value in differentiating between these patients and those with 'simple ' obesity since the latter usually showed a normal growth hormone and adrenal response provided an adequate amount of insulin was administered. The patients with Cushing's disease also had an impaired adrenal response to pyrogen and to dexamethasone administration and failed to show a normal plasma 11-hydroxycorticosteroid circadian rhythm. Their response to corticotrophin, lysine vasopressin, and metyrapone, however, was normal or enhanced. It is suggested that these findings imply an abnormality of hypothalamic or cerebral control and not a primary defect of pituitary function as proposed originally by Harvey Cushing. The growth hormone response to insulin remained impaired in four out of six patients totally adrenalectomized for Cushing's disease but was normal in three patients adrenalectomized for other reasons. It is suggested that the defect which impairs the adrenal response to insulin may, on occasions, also impair the mechanism normally operative for growth hormone secretion.

Mechanism of impaired growth hormone secretion in patients with Cushing's disease

1992 ◽  
Vol 127 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Hideo Takahashi ◽  
Hiroshi Bando ◽  
Chenyu Zhang ◽  
Ryuichi Yamasaki ◽  
Shiro Saito
Keyword(s):  
Growth Hormone ◽  
Cushing’S Disease ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Cushing's Disease ◽  
Gh Secretion ◽  
Highly Sensitive ◽  
Low Levels ◽  
Plasma Gh ◽  
Observation Period

The function of the growth hormone-releasing hormone (GHRH)-growth hormone (GH) axis in Cushing's disease was studied by monitoring (a) the GH responses to GHRH loading and L-dopa loading, (b) the GHRH response to L-dopa loading, and (c) the daytime profiles of plasma GH concentration. GH release following GHRH and L-dopa was blunted in patients as compared to that in age-matched control subjects. However, GHRH release following L-dopa was similar in patients and controls. The plasma GH levels in four patients measured every 20 min by a highly sensitive immunoradiometric assay for GH showed pulsatile GH secretion at low levels during the observation period. These results indicate that GHRH release from the hypothalamus is preserved in patients with Cushing's disease, and support the hypothesis that glucocorticoid inhibits GH secretion by altering the hypothalamic somatostatin tone.

EFFECT OF l-DOPA ADMINISTRATION ON GROWTH HORMONE SECRETION IN NORMAL SUBJECTS AND PARKINSONIAN PATIENTS

1972 ◽  
Vol 54 (3) ◽  
pp. 425-433 ◽  
Author(s):  
F. CAVAGNINI ◽  
M. PERACCHI ◽  
G. SCOTTI ◽  
U. RAGGI ◽  
A. E. PONTIROLI ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Subjects ◽  
Significant Rise ◽  
Arginine Infusion ◽  
Physiological Regulation ◽  
Gh Secretion ◽  
Before And After ◽  
Serum Gh

SUMMARY The effect of both oral and intravenous administration of l-DOPA on growth hormone (GH) secretion was studied in a group of normal volunteers: a significant rise of serum GH levels was observed in both cases. Growth hormone release in response to insulin hypoglycaemia and to arginine infusion was evaluated in a group of Parkinsonian patients before and after 25 days' treatment with l-DOPA plus a DOPA-decarboxylase inhibitor. In addition, GH response to the above stimuli was studied in a group of patients who had been under treatment for more than 6 months with l-DOPA alone. In untreated Parkinsonian patients, GH response to insulin hypoglycaemia was at the lower limit of normal range while arginine-induced GH release was significantly reduced. Treatment with l-DOPA did not increase GH responses. Some possible interpretations of the results are discussed. The findings support the possibility that dopamine plays a role in the physiological regulation of GH secretion, as in the case of luteinizing hormone, follicle-stimulating hormone and prolactin release.

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