Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells

1992 ◽  
Vol 75 (1) ◽  
pp. 183-188 ◽  
Author(s):  
J. Timsit
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Hormonal Function ◽  
Growth Factor I

Effects of growth hormone and insulin-like growth factor I on the immune system

1995 ◽  
Vol 133 (6) ◽  
pp. 635-645 ◽  
Author(s):  
Christoph J Auernhammer ◽  
Christian J Strasburger
Keyword(s):  
Growth Hormone ◽  
Immune System ◽  
Growth Factor ◽  
Killer Cell ◽  
Immunocompetent Cells ◽  
Thymic Epithelial Cells ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Auernhammer CJ, Strasburger CJ. Effects of growth hormone and insulin-like growth factor I on the immune system. Eur J Endocrinol 1995;133:635–45. ISSN 0804–4643 Growth hormone-releasing hormone (GHRH). growth hormone (GH), prolactin (PRL) and insulin-like growth factor I (IGF-I) are synthesized and secreted by various immunocompetent cells. In addition, GHRH, GH, PRL and IGF-I receptors are expressed on immune cells. Growth hormone, PRL and IGF-I stimulate the proliferation of immunocompetent cells and modulate humoral and cellular immune functions, i.e. immunoglobuline secretion of B cells, thymulin secretion of thymic epithelial cells, natural killer cell activity, phagocytosis, oxidative burst and killing capacity of neutrophils and macrophages. No clinically significant cellular or humoral immunodeficiency has been found in GH-deficient patients. However, several immunological parameters and functions are altered in GH-deficient patients when compared to normal controls. The data available to date indicate that endocrine and pleiotropic para- and autocrine mechanisms of action are involved in a neuropeptide immune network, including GH PRL and IGF-I as modulators of immune function. Christian J Strasburger, Medizinische Klinik, Klinikum Innenstadt der LMU, Ziemssenstr. 1, 80336 Munich, Germany

Insulin-like growth factor-I restores the reduced somatostatinergic tone controlling growth hormone secretion in cirrhotic rats

2001 ◽  
Vol 21 (6) ◽  
pp. 405-409 ◽  
Author(s):  
Inma Castilla-Cortázar ◽  
M. Aurelia Aliaga-Montilla ◽  
Javier Salvador ◽  
María García ◽  
Gloria Delgado ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I
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