scholarly journals Longitudinal Relationships of Circulating Reproductive Hormone With Functional Disability, Muscle Mass, and Strength in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project

2014 ◽  
Vol 99 (9) ◽  
pp. 3310-3318 ◽  
Author(s):  
Benjumin Hsu ◽  
Robert G. Cumming ◽  
Vasi Naganathan ◽  
Fiona M. Blyth ◽  
David G. Le Couteur ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Functional Disability ◽  
Older Men ◽  
Community Dwelling ◽  
Reproductive Hormone ◽  
Longitudinal Relationships

scholarly journals Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS)

2018 ◽  
Vol 103 (1) ◽  
pp. 35-43 ◽  
Author(s):  
H. P. Patel ◽  
A. Dawson ◽  
L. D. Westbury ◽  
G. Hasnaoui ◽  
H. E. Syddall ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Bone Health ◽  
Older Men ◽  
Community Dwelling ◽  
Muscle Morphology

scholarly journals Reproductive Hormone Levels Predict Changes in Frailty Status in Community-Dwelling Older Men: European Male Ageing Study Prospective Data

2017 ◽  
Vol 103 (2) ◽  
pp. 701-709 ◽  
Author(s):  
Agnieszka Swiecicka ◽  
Robert J A H Eendebak ◽  
Mark Lunt ◽  
Terence W O’Neill ◽  
György Bartfai ◽  
...  
Keyword(s):  
Older Men ◽  
Community Dwelling ◽  
Reproductive Hormone ◽  
Prospective Data ◽  
Hormone Levels ◽  
Frailty Status ◽  
Ageing Study ◽  
Male Ageing

scholarly journals Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men

2011 ◽  
Vol 164 (5) ◽  
pp. 811-817 ◽  
Author(s):  
Tung Wai Auyeung ◽  
Jenny Shun Wah Lee ◽  
Timothy Kwok ◽  
Jason Leung ◽  
Claes Ohlsson ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Grip Strength ◽  
Muscle Mass ◽  
Physical Performance ◽  
Older Men ◽  
Community Dwelling ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Cross Sectional ◽  
Skeletal Mass

ObjectiveTo examine the relationship between different measures of testosterone and estradiol (E2), muscle mass, muscle strength, and physical performance; and to test whether the association of sex hormone level with muscle strength and physical performance was independent of muscle mass.Design and methodsA cross-sectional survey on 1489 community-dwelling men older than 64 years of age. Serum levels of testosterone and E2were measured by mass spectrometry, and sex hormone-binding globulin (SHBG) levels were measured by immunoradioassay. Muscle mass was examined by dual-energy X-ray absorptiometry and physical performance was assessed by hand-grip strength, gait speed, step length and chair-stand test.ResultsAppendicular skeletal mass (ASM) was positively associated with total testosterone (TT;P<0.001), free testosterone (FT;P<0.001), and total E2(P<0.001) but not with free E2(P=0.102). After adjustment for age, serum SHBG and relative ASM, both TT and FT were significantly associated with grip strength, narrow-walk speed and the composite neuromuscular score. Higher total E2, but not free E2was associated with lower grip strength (P<0.05) after adjustment for age, FT, SHBG and relative ASM.ConclusionsTestosterone level was related to both muscle mass, strength and physical performance. Total E2level, though related to muscle mass positively, affected muscle strength adversely in older men.

scholarly journals THE ASSOCIATION BETWEEN D3CR MUSCLE MASS AND MORTALITY IN COMMUNITY-DWELLING OLDER MEN

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S84-S84 ◽  
Author(s):  
Peggy M Cawthon ◽  
Terri Blackwell ◽  
Steven R Cummings ◽  
Eric S Orwoll ◽  
Kate A Duchowny ◽  
...  
Keyword(s):  
Risk Factor ◽  
Muscle Mass ◽  
Proportional Hazards ◽  
Smoking Status ◽  
Older Men ◽  
Community Dwelling ◽  
Adverse Health Outcomes ◽  
Injurious Falls ◽  
Clinical Center ◽  
Mortality Outcome

Abstract We have shown that men with low muscle mass assessed by D3Cr (deuterated creatine) dilution are more likely to have worse physical performance and incident fractures, injurious falls and disability. However, the relation between D3Cr muscle mass and mortality is unknown. With data from Year 14 Visit of the MrOS study (N=1400, mean age 84.2 yrs), proportional hazards models estimated the risk of mortality (hazard ratio and 95% CI) by quartiles of D3Cr muscle mass (standardized to body mass); we calculated p for trend across quartiles. Models were adjusted for age, race, clinical center, alcohol use, smoking status, comorbidities, activity, percent fat, exhaustion, and cognitive function. Cause of death was centrally adjudicated. Over 3.3±0.8 years of follow-up, 197 (14.1%) men died. Men in the lowest quartile of D3Cr muscle mass/wgt were 2.8-fold more likely to die than men in the highest quartile (HR: 2.8, 95% CI: 1.6, 4.9; p for trend&lt;.001). The HRs for each cause-specific mortality outcome were of similar magnitude to the HR for overall mortality: cancer death (HR, Q1 vs Q4: 2.2, 95% CI: 0.7, 7.1; p trend =0.140); CVD death (HR, Q1 vs Q4: 3.7, 95% CI: 1.3, 10.5; p trend =0.008); or non-cancer non-CVD death (HR, Q1 vs Q4: 2.4, 95% CI: 1.0, 5.6; p trend=0.019). We conclude that low muscle mass assessed by D3Cr dilution is a strong risk factor for mortality in older men, providing additional evidence that low muscle mass is an important risk factor for adverse health outcomes.

scholarly journals Muscle Mass Assessed by the D3-Creatine Dilution Method and Incident Self-reported Disability and Mortality in a Prospective Observational Study of Community-Dwelling Older Men

2020 ◽  
Vol 76 (1) ◽  
pp. 123-130 ◽  
Author(s):  
Peggy M Cawthon ◽  
Terri Blackwell ◽  
Steven R Cummings ◽  
Eric S Orwoll ◽  
Kate A Duchowny ◽  
...  
Keyword(s):  
Risk Factor ◽  
Muscle Mass ◽  
Lean Mass ◽  
Negative Binomial ◽  
Older Men ◽  
Community Dwelling ◽  
Dilution Method ◽  
Relative Risks ◽  
Clinical Center ◽  
Adl Disability

Abstract Background Whether low muscle mass is a risk factor for disability and mortality is unclear. Associations between approximations of muscle mass (including lean mass from dual-energy x-ray absorptiometry [DXA]), and these outcomes are inconsistent. Methods Muscle mass measured by deuterated creatine (D3Cr) dilution and appendicular lean mass (ALM, by DXA) were assessed at the Year 14 Visit (2014–2016) of the prospective Osteoporotic Fractures in Men study (N = 1,425, age 77–101 years). Disability in activities of daily living (ADLs), instrumental ADLs, and mobility tasks was self-reported at the Year 14 visit and 2.2 years later; deaths were centrally adjudicated over 3.3 years. Relative risks and 95% confidence intervals (CI) were estimated per standard deviation decrement with negative binomial, logistic regression, or proportional hazards models. Results In age- and clinical center-adjusted models, the relative risks per decrement in D3Cr muscle mass/wgt was 1.9 (95% CI: 1.2, 3.1) for incident self-reported ADL disability; 1.5 (95% CI: 1.3, 1.9) for instrumental ADL disability; and 1.8 (95% CI: 1.5, 2.2) for mobility disability. In age-, clinical center-, and weight-adjusted models, the relative risks per decrement in D3Cr muscle mass was 1.8 (95% CI: 1.5, 2.2) for all-cause mortality. In contrast, lower DXA ALM was not associated with any outcome. Associations of D3Cr muscle mass with these outcomes were slightly attenuated after adjustment for confounding factors and the potentially mediating effects of strength and physical performance. Conclusions Low muscle mass as measured by D3Cr dilution is a novel risk factor for clinically meaningful outcomes in older men.

scholarly journals Combined Effects of Having Sleep Problems and Taking Sleeping Pills on the Skeletal Muscle Mass and Performance of Community-Dwelling Elders

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chuan-Wei Yang ◽  
Chia-Ing Li ◽  
Tsai-Chung Li ◽  
Chiu-Shong Liu ◽  
Chih-Hsueh Lin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Sleep Problems ◽  
Older Men ◽  
Community Dwelling ◽  
Men And Women ◽  
Sleeping Pills ◽  
The Status ◽  
And Performance

Abstract This study aimed to explore the combined effects of having sleep problems and taking sleeping pills on the skeletal muscle mass and performance of community-dwelling elders. A total of 826 participants who have complete information regarding dual-energy X-ray absorptiometry examination, questionnaire, and physical performance tests were included. The status of having sleep problems and taking sleeping pills was assessed with a self-reported questionnaire. The prevalence rates of sleep problems among older men and women were 37.4% and 54.5%, respectively. After multivariate adjustment, the mean height-adjusted skeletal muscle indices for elders having sleep problems and taking sleeping pills among men and women were 7.29 and 5.66 kg/m2, respectively, which were lower than those without sleep problems (P = 0.0021 and P = 0.0175). The performance of the older men having sleep problems and taking sleeping pills in terms of walking speed, grip strength, and number of squats, was poorer than those of the older men without sleep problems. The status of having sleep problems and taking sleeping pills was correlated with low skeletal muscle mass and poor physical performance in community-dwelling elders. These findings suggest that having sleep problems and taking sleeping pills are associated with having sarcopenia among community elderly.

scholarly journals Amount of Protein Required to Improve Muscle Mass in Older Adults

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1700
Author(s):  
Doyeon Kim ◽  
Yongsoon Park
Keyword(s):  
Older Adults ◽  
Older Women ◽  
Muscle Mass ◽  
Gait Speed ◽  
Protein Intake ◽  
Older Men ◽  
Community Dwelling ◽  
Age Related ◽  
And Function ◽  
Habitual Protein Intake

Increased protein intake has been suggested as an effective strategy to treat age-related loss of muscle mass and function, but the amount of protein required to improve muscle and function without exercise in older adults remains unclear. Thus, this secondary data analysis aimed to assess what amount of protein from habitual protein intake was positively associated with changes in muscle mass and gait speed in older women and men. Ninety-six community-dwelling older adults consumed 0.8, 1.2, or 1.5 g/kg/day of protein and maintained their usual physical activity for 12 weeks. Increased protein intake of >0.54 g/kg/day was positively associated with changes in appendicular skeletal muscle mass (ASM)/weight (B = 0.591, p = 0.026), ASM/body mass index (B = 0.615, p = 0.023), and ASM:fat ratio (B = 0.509, p = 0.030) in older men. However, change in protein intake was not associated with change in muscle mass in older women. Additionally, change in protein intake was not associated with change in gait speed in older women and men. The present study suggested that an increased absolute protein amount of >0.54 g/kg/day from habitual protein intake was positively associated with change in muscle mass in older men.

Region-Specific Fat Mass and Muscle Mass and Mortality in Community-Dwelling Older Men and Women

Gerontology ◽  
2012 ◽  
Vol 58 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Hanneke A.H. Wijnhoven ◽  
Marieke B. Snijder ◽  
Marian A.E. van Bokhorst-de van der Schueren ◽  
Dorly J.H. Deeg ◽  
Marjolein Visser
Keyword(s):  
Muscle Mass ◽  
Fat Mass ◽  
Older Men ◽  
Community Dwelling ◽  
Men And Women ◽  
Older Men And Women

scholarly journals The association between nutritional status and cognitive impairment in Brazilian community-dwelling older adults assessed using a range of anthropometric measures - the Bambui Study

2013 ◽  
Vol 7 (4) ◽  
pp. 403-409 ◽  
Author(s):  
Érico Castro-Costa ◽  
Sérgio V. Peixoto ◽  
Josélia O.A. Firmo ◽  
Elizabeth Uchoa ◽  
Maria Fernanda F. Lima-Costa
Keyword(s):  
Cognitive Impairment ◽  
Nutritional Status ◽  
Muscle Mass ◽  
Functional Disability ◽  
The Elderly ◽  
Skinfold Thickness ◽  
Community Dwelling ◽  
Muscle Area ◽  
Anthropometric Measures ◽  
Community Dwelling Older Adults

ABSTRACT In most studies, body mass index (BMI) has been used as the main measurement of nutritional status. However, BMI does not differentiate between body fat and muscle mass. Objective: To investigate the association between nutritional status and cognitive impairment in a population of Brazilian elderly. Methods: Participants (n=1,496) from the Bambuí Cohort Study of Aging were selected based on the results for the two variables nutritional status and cognitive impairment (MMSE score). Gender, age, education, lifestyle, ApoE, chronic diseases, depressive symptoms, current use of hypnotic or sedative medication and functional disability were used as confounding factors for adjusting the logistic regression. Results: Cognitive impairment was associated with lower BMI (OR: 0.91; CI: 0.86-0.95), waist circumference (OR: 0.97; CI: 0.95-0.99), triceps skinfold thickness (OR: 0.92; CI: 0.89-0.96) among the younger participants (60-69 years), while lower arm muscle circumference (OR: 0.88; CI: 0.80-0.98) and corrected arm muscle area (OR: 0.96; CI: 0.93-0.99) were associated with cognitive impairment among the older participants (70 years and over). Conclusion: There was a difference of association between anthropometric measures and cognitive impairment after stratifying by age group. In the group aged between 60 and 69, cognitive impairment was associated with measures related to fat mass, while in the group aged over 70, cognitive impairment was associated with measures related to muscle mass. This finding suggests that investigation of nutritional status in the elderly using anthropometric measures should not be restricted only to the use of BMI, and should also, differ according to age.

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