scholarly journals Hypothesis: Cystic fibrosis carrier geography reflects interactions of tuberculosis and hypertension with vitamin D deficiency, altitude and temperature. Vitamin D deficiency effects and cf carrier advantage

2012 ◽  
Vol 11 (1) ◽  
pp. 68-70 ◽  
Author(s):  
Mark Lubinsky
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cystic Fibrosis Carrier

P06 A study to assess the effectiveness of vitamin d supplementation in paediatric cystic fibrosis patients

2018 ◽  
Vol 103 (2) ◽  
pp. e1.9-e1
Author(s):  
Christiansen Nanna ◽  
Ashraf Saleha
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Dose Range ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
List Type ◽  
Current Guideline ◽  
Paediatric Patients ◽  
Significant Difference

AimsPatients with cystic fibrosis (CF) require supplementation of fat-soluble vitamins due to the effects of the disease on the pancreas and the resulting inability of absorb fat effectively.1The study aimed to assess the effectiveness of current of vitamin D supplementation to achieve adequate serum Vitamin D (25OHD) levels in paediatric CF patients.2 Secondly, this study assessed the effectiveness of ‘Stoss’ therapy (a high dose vitamin D therapy administered every three months) as an alternative to daily vitamin D supplementation for patients with known poor compliance.3MethodsVitamin D doses and serum 25OHD levels between January and December 2016 were reviewed for paediatric CF patients at a UK centre. Data was collected for 138 paediatric patients. The ‘clinical record summary’ system was used to extract the data which included age, hospital number, weight in 2015 and 2016, 25OHD levels from 2015 and 2016, vitamin D dose before each level and pancreatic status.Data was entered onto Statistical Package for the Social Sciences (SPSS) system for analysis. A paired T-test was conducted to ascertain if there was a significant difference in weekly/kg doses between patients that were sufficient (25OHD>50 nmol/L) and insufficient (25OHD<50 nmol/L).ResultsData was collected for a total of 138 patients. The data from only 70 patients was analysed when investigating the first objective, as all other patients did not have 25OHD levels available for both 2015 and 2016. A further five patients wereexcluded and analysed seperately due to receiving Stoss therapy. The weekly Vitamin D dose range was very wide for both years with 43% (n=40) of patients requiring additional vitamin D in addition to Aquadeks (CF multivitamin preparation). There was no significant difference in Vitamin D doses between patients with sufficient and insufficient 25OHD levels. This was thecase for both 2015 (p=0.432) and 2016 (p=0.192). The daily supplementation doses were successful at maintaining vitamin D sufficiency for 83% of patients in 2015 and 93% in 2016.Out of the 5 patients who received ‘Stoss’ therapy, 3 had an increase in 25OHD levels. However, only one of the patients had a significant increase leading to sufficient 25OHD levels. In 2 cases there was actually a 60%–68% decrease in 25OHD levels, which lead to these patients developing vitamin D deficiency.ConclusionThis study was useful in determining the effectiveness of current Vitamin D dosing. The results suggest that patients having insufficient 25OHD levels may not be due to an inadequacy of doses provided in the current guideline, as there was no significant difference in dose between patients with sufficient and insufficient 25OHD levels. Given the patient group, the difference could be attributable to a lack of compliance to daily therapies in the patients with insufficient 25OHD levels or even differences in individual responses to therapy.In this sample, ‘Stoss’ therapy is not effective in maintaining sufficient 25OHD levels. Although the data for this part of the study was very limited, it identifies a need to investigate the effectiveness of ‘Stoss’ therapy further.ReferencesFerguson JH, Chang AB. Vitamin D supplementation for cystic fibrosis. Cochrane Database of Syst Rev [Internet] 2014. http://onlinelibrary.wiley.com/ & doi:10.1002/14651858.CD007298.pub3/pdf [Available: 2017April 12].Green D, Carson K, Leonard A, et al. Current treatment recommendations for correcting vitamin D deficiency in paediatric patients with cystic fibrosis is inadequate. J Pediatr2008;4:554–559.Shepherd D, Belessis Y, Katz, et al. Single high-dose oral vitamin D3 (stoss) therapy: A solution to vitamin D deficiency in children with cystic fibrosis?J Cyst Fibros2013;2:177–182.

scholarly journals Vitamin D deficiency and its treatment in cystic fibrosis

2019 ◽  
Vol 18 ◽  
pp. S66-S73 ◽  
Author(s):  
Tanicia Daley ◽  
Kara Hughan ◽  
Maria Rayas ◽  
Andrea Kelly ◽  
Vin Tangpricha
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency

scholarly journals 289 Vitamin D deficiency in patients attending the Tuscan regional cystic fibrosis centre

2013 ◽  
Vol 12 ◽  
pp. S122
Author(s):  
V. Galici ◽  
T. Repetto ◽  
A. Neri ◽  
C. Braggion ◽  
M. de Martino ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cystic Fibrosis Centre

Current Treatment Recommendations for Correcting Vitamin D Deficiency in Pediatric Patients with Cystic Fibrosis Are Inadequate

2008 ◽  
Vol 153 (4) ◽  
pp. 554-559.e2 ◽  
Author(s):  
Deanna Green ◽  
Kathryn Carson ◽  
Amanda Leonard ◽  
J. Erin Davis ◽  
Beryl Rosenstein ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Pediatric Patients ◽  
Current Treatment ◽  
Treatment Recommendations

Vitamin D Deficiency Is Associated with Increased Nontuberculous Mycobacteria Risk in Cystic Fibrosis

2020 ◽  
Author(s):  
William J Richter ◽  
Yuqing Sun ◽  
Kevin J Psoter ◽  
Matthew N Santos ◽  
Jan A Nguyen ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Nontuberculous Mycobacteria

scholarly journals Vitamin D deficiency as a risk factor for cystic fibrosis-related diabetes in the Scandinavian Cystic Fibrosis Nutritional Study

Diabetologia ◽  
2011 ◽  
Vol 54 (12) ◽  
pp. 3007-3015 ◽  
Author(s):  
T. Pincikova ◽  
◽  
K. Nilsson ◽  
I. E. Moen ◽  
G. Fluge ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Risk Factor ◽  
Vitamin D Deficiency ◽  
Nutritional Study

Vitamin D(25-OH-cholecalciferol) in Cystic Fibrosis and the Relations with Cholesterol and Proteins

2019 ◽  
Vol 70 (9) ◽  
pp. 3185-3187
Author(s):  
Ioana Mihaiela Ciuca ◽  
Liviu Laurentiu Pop ◽  
Mihaela Dediu ◽  
Sonia Aniela Tanasescu ◽  
Florina Ardelean ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Logistic Regression ◽  
Vitamin D Deficiency ◽  
Pearson Correlation ◽  
Negative Relationship ◽  
Serum Levels ◽  
Average Value ◽  
Vitamin D Levels ◽  
25 Hydroxycholecalciferol

Study aimed to assess the level of 25-OH-cholecalciferol(vitamin D) and the relation with cholesterol, proteins and glycaemia levels in patients with cystic fibrosis. 58 patients underwent for the annual evaluations and were tested for vitamin D deficiency, as the centre�s protocol requires, besides dosage of cholesterol, glycaemia and proteins levels. Serum levels of 25-hydroxycholecalciferol were compared to levels of cholesterol, proteins and glycaemia, using Pearson correlation and logistic regression. The average value of 25-OH-cholecalciferol was 22,9 ng/mL, suggesting an important deficiency and different stages of 25-OH-cholecalciferol deficiency was found in the majority of patients. Nor a positive correlation neither negative relationship was found between vitamin D and cholesterol (r=0,23), glycaemia or proteins level. Vitamin D levels are not related to cholesterol or proteins in our study. Although cystic fibrosis is characterised by liposoluble vitamins deficiency and lipids impaired digestion, other factors influence the seric levels of vitamin D and lipids.

Bone Mass and Vitamin D Deficiency in Adults with Advanced Cystic Fibrosis Lung Disease

1998 ◽  
Vol 157 (6) ◽  
pp. 1892-1899 ◽  
Author(s):  
DANIEL S. DONOVAN ◽  
ANASTASIO PAPADOPOULOS ◽  
RONALD B. STARON ◽  
VICKI ADDESSO ◽  
LARRY SCHULMAN ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Bone Mass ◽  
Lung Disease ◽  
Vitamin D Deficiency ◽  
Cystic Fibrosis Lung ◽  
Cystic Fibrosis Lung Disease
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