scholarly journals C-Reactive Protein in Adolescent Twins: Patterns and Relationship to Adiposity

2011 ◽  
Vol 96 (10) ◽  
pp. 3226-3233 ◽  
Author(s):  
Guoying Wang ◽  
Katherine Kaufer Christoffel ◽  
Wendy J. Brickman ◽  
Xiumei Hong ◽  
Lester Arguelles ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Body Fat ◽  
Genetic Factors ◽  
Tanner Stage ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Phenotypic Correlations ◽  
Fat Composition ◽  
Adolescent Twins ◽  
Shared Genetic

Abstract Context: Elevated C-reactive protein (CRP) is a marker of cardiovascular risk in adults. Patterns and determinants of CRP in adolescents have not been well described. Objective: This study aimed to determine how CRP varies by age, gender, Tanner stage, and body fat composition in rural Chinese adolescents and to what degree adiposity-CRP associations are attributable to shared genetic and environmental factors. Design and Setting: Data were derived from an ongoing study of metabolic syndrome in a large community-based twin cohort enrolled in Anqing, China. Participants: The study sample included 1180 adolescent twins aged 13–21 yr. Main Outcome Measures: Plasma CRP concentrations were measured by sandwich immunoassay using flow metric xMAP technology. Body fat composition was assessed by dual-energy x-ray absorptiometry. Results: CRP levels linearly increased across age and Tanner stage in males (P ≤ 0.0001), but in females, CRP exhibited no trend after adjusting for fat mass (P > 0.05). For males, the most explanatory measure was body mass index (partial r2 = 5.2%), whereas percent body fat (partial r2 = 8.8%) was more explanatory in females. Of the phenotypic correlations between adiposity measures and CRP (0.25–0.28), 86–89% were attributed to shared genetic factors and 11–14% to common unique environmental factors in both sexes. Conclusions: Adiposity is a strong determinant of CRP even in this relatively lean Chinese population. There is notable gender difference for the CRP pattern and the relationship of CRP with adiposity during adolescence. To a large degree, common genetic factors may underlie the observed adiposity-CRP-phenotypic correlations.

Correlation between the body fat composition and high sensitive C-reactive protein in Turkish adults

2012 ◽  
Vol 46 (03) ◽  
pp. 147-152 ◽  
Author(s):  
M. Aydin ◽  
T. Dumlu ◽  
R. Alemdar ◽  
O. Kayapinar ◽  
G. Celbek ◽  
...  
Keyword(s):  
Body Fat ◽  
The Body ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Fat Composition

scholarly journals Endurance and resistance training lowers C-reactive protein in young, healthy females

2011 ◽  
Vol 36 (5) ◽  
pp. 660-670 ◽  
Author(s):  
Laura A. Daray ◽  
Tara M. Henagan ◽  
Michael Zanovec ◽  
Conrad P. Earnest ◽  
Lisa G. Johnson ◽  
...  
Keyword(s):  
Body Composition ◽  
Resistance Training ◽  
Body Fat ◽  
Aerobic Capacity ◽  
C Reactive Protein ◽  
Young Females ◽  
Marathon Training ◽  
Reactive Protein ◽  
Body Strength ◽  
Additional Resistance

The purpose of this study was to determine whether endurance (E) or endurance + resistance (ER) training affects C-reactive protein (CRP) and if these changes are related to alterations in fitness and (or) body composition in young females. Thirty-eight females (aged 18–24 years) were assigned to 1 of 3 groups: (1) E, (2) ER or (3) active control (AC). The E and ER groups completed 15 weeks of marathon training. The ER group performed additional resistance training and the AC group maintained their usual exercise routine. Primary outcomes were measured pre- and post-training and included anthropometric indices, dual-energy x-ray absorptiometry, plasma CRP, time to complete 1.5 miles (in minutes), and upper and lower body strength tests (i.e., 8 repetition max on bench and leg press (ER group only)). There were no differences in any variable among the groups at baseline. After training, the E group decreased time to complete 1.5 miles (p < 0.05). The AC group decreased percent and absolute body fat while the E group decreased percent body fat, absolute body fat, and android and gynoid body fat (p < 0.05). The ER group significantly improved strength (p < 0.001) and reduced plasma CRP from 2.0 ± 1.1 to 0.8 ± 0.3 mg·L–1 (p = 0.03). No significant associations were observed between CRP and measures of body composition or aerobic capacity. Combined endurance and resistance training may be an effective modality for reducing plasma CRP in young adult females independent of changes in aerobic capacity or body composition.

scholarly journals Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women

Biomarkers ◽  
2010 ◽  
Vol 15 (8) ◽  
pp. 663-670 ◽  
Author(s):  
Fatima Nayeem ◽  
Karl E. Anderson ◽  
Manubai Nagamani ◽  
James J. Grady ◽  
Lee-Jane W. Lu
Keyword(s):  
Alkaline Phosphatase ◽  
Body Fat ◽  
Premenopausal Women ◽  
C Reactive Protein ◽  
Percentage Body Fat ◽  
Reactive Protein

scholarly journals Impact of Genetic and Environmental Factors on hsCRP Concentrations and Response to Therapeutic Agents

2009 ◽  
Vol 55 (2) ◽  
pp. 256-264 ◽  
Author(s):  
Jian Shen ◽  
Jose M Ordovas
Keyword(s):  
Environmental Factors ◽  
Genetic Polymorphisms ◽  
Genetic Variants ◽  
Inflammatory Marker ◽  
Lipid Lowering ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Fenofibrate Treatment ◽  
Genetic And Environmental Factors ◽  
The Impact

Abstract Background: Inflammation plays an instrumental role in all stages of atherosclerosis. High-sensitivity C-reactive protein (hsCRP), a systemic inflammatory marker, has been gaining recognition as an independent risk factor for cardiovascular disease (CVD). Both baseline hsCRP concentrations and drug-induced hsCRP changes are highly variable and potentially subject to genetic regulation. Content: This review summarizes the current studies examining the effect of genetic and environmental factors on baseline plasma hsCRP concentrations, with a main focus on C-reactive protein, pentraxin-related (CRP) genetic polymorphisms and various dietary components that affect hsCRP concentrations. We also address the association of CRP genetic variations with CVD risk, a relationship that may support or refute the causality of CRP in the atherosclerotic process. Moreover, we discuss the impact of CRP genetic polymorphisms on hsCRP changes in response to 3-week fenofibrate treatment in the genetic intervention of the Genetics of Lipid Lowering Drugs and Diet Network study. Summary: Genetic variants on the CRP locus and other loci and dietary and lifestyle factors are responsible for the interindividual variability of plasma hsCRP concentrations. CRP genetic variants further influence differing plasma hsCRP response after 3-week fenofibrate treatment in patients with metabolic syndrome. Future studies focusing on the influence and interaction of genetic variation on the hsCRP response to dietary and other behavior modification as well as drug treatment could have important implications for the development of more personalized preventive and therapeutic approaches to reduce CVD.

Physical activity, body fat, and serum c-reactive protein in postmenopausal women with and without hormone replacement

2003 ◽  
Vol 15 (1) ◽  
pp. 91-100 ◽  
Author(s):  
Patricia J. Manns ◽  
Daniel P. Williams ◽  
Christine M. Snow ◽  
Rosemary C. Wander
Keyword(s):  
Physical Activity ◽  
Postmenopausal Women ◽  
Body Fat ◽  
Hormone Replacement ◽  
C Reactive Protein ◽  
Reactive Protein
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