Physical activity, body fat, and serum c-reactive protein in postmenopausal women with and without hormone replacement

2003 ◽  
Vol 15 (1) ◽  
pp. 91-100 ◽  
Author(s):  
Patricia J. Manns ◽  
Daniel P. Williams ◽  
Christine M. Snow ◽  
Rosemary C. Wander
Keyword(s):  
Physical Activity ◽  
Postmenopausal Women ◽  
Body Fat ◽  
Hormone Replacement ◽  
C Reactive Protein ◽  
Reactive Protein

Plasma C-reactive protein is not elevated in physically active postmenopausal women taking hormone replacement therapy

2004 ◽  
Vol 96 (1) ◽  
pp. 143-148 ◽  
Author(s):  
Brian L. Stauffer ◽  
Greta L. Hoetzer ◽  
Derek T. Smith ◽  
Christopher A. DeSouza
Keyword(s):  
Physical Activity ◽  
Hormone Replacement Therapy ◽  
Postmenopausal Women ◽  
Endurance Exercise ◽  
Cardiovascular Events ◽  
Hormone Replacement ◽  
C Reactive Protein ◽  
Physically Active ◽  
Reactive Protein ◽  
Sedentary Women

We tested the hypothesis that hormone replacement therapy (HRT)-related increases in C-reactive protein (CRP) would either be blunted or absent in postmenopausal women who regularly perform endurance exercise. Plasma CRP is an independent predictor of future cardiovascular events in healthy men and women. Oral HRT increases plasma CRP concentrations in postmenopausal women. Regular aerobic exercise reduces the risk of cardiovascular events and is associated with lower CRP concentrations in adults. To date, no study has evaluated the influence of habitual physical activity on the elevation of CRP associated with HRT. Plasma CRP concentrations were measured in 114 postmenopausal women: 39 physically active (endurance trained) and 75 sedentary postmenopausal subjects. Sixty-five women were users of HRT (22 physically active and 43 sedentary), and 49 were nonusers (17 physically active and 32 sedentary). CRP levels were ∼75% higher ( P < 0.01) in the sedentary users vs. nonusers of HRT (1.9 ± 1.8 vs. 1.1 ± 1.0 mg/l). In contrast, there was no difference in CRP levels between the physically active users and nonusers of HRT (0.6 ± 0.4 vs. 0.4 ± 0.2 mg/l; P = 0.61). Regardless of HRT status, CRP concentrations were ∼65% lower in the physically active compared with sedentary women. In conclusion, physically active postmenopausal women exhibit lower plasma CRP concentrations compared with sedentary controls. Importantly, the HRT-related elevation in plasma CRP levels observed in sedentary women is absent in women who engage in regular endurance exercise. These data suggest that habitual physical activity may prevent the elevation in CRP concentrations due to HRT.

Hormone replacement therapy, C-reactive protein, and fibrinogen in healthy postmenopausal women

Maturitas ◽  
2003 ◽  
Vol 46 (4) ◽  
pp. 245-253 ◽  
Author(s):  
Mehmet Yilmazer ◽  
Veysel Fenkci ◽  
Semin Fenkci ◽  
Murat Sonmezer ◽  
Orhan Aktepe ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Hormone Replacement ◽  
C Reactive Protein ◽  
Reactive Protein

Does the type of hormone replacement therapy affect lipoprotein (a), homocysteine, and C-reactive protein levels in postmenopausal women?

Metabolism ◽  
2005 ◽  
Vol 54 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Hanna Bukowska ◽  
Stanisław Stanosz ◽  
Ewa Żochowska ◽  
Barbara Millo ◽  
Krzysztof Sieja ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Hormone Replacement ◽  
C Reactive Protein ◽  
Lipoprotein A ◽  
Protein Levels ◽  
Reactive Protein

Increased C-reactive Protein Levels during Short-term Hormone Replacement Therapy in Healthy Postmenopausal Women

1999 ◽  
Vol 81 (06) ◽  
pp. 925-928 ◽  
Author(s):  
Marchien van Baal ◽  
Peter Kenemans ◽  
Marius van der Mooren ◽  
Hilda Kessel ◽  
Jef Emeis ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Hormone Replacement ◽  
Initial Increase ◽  
C Reactive Protein ◽  
Short Term ◽  
Short Term Treatment ◽  
Reactive Protein ◽  
Increased Risk

Summary Objective: To study the short-term effect of unopposed oestradiol (E2) and sequentially combined hormone replacement therapy (E2 + P) on C-reactive protein (CRP) in healthy postmenopausal women. Design: Prospective, randomised, placebo-controlled 12-week study. Sixty healthy, normotensive, non-hysterectomised postmenopausal women received either placebo (N = 16) or daily 2 mg micronised oestradiol, either unopposed (N = 16, E2 group) or sequentially combined with a progestagen on 14 days of each cycle (N = 28, E2+P group). Data were collected at baseline and at 4 and 12 weeks. Results: CRP levels increased significantly during the 12 weeks in the E2 and the E2+P groups compared to placebo. No differences were found between the E2 group and the E2+P group [E2 and E2+P group together (N = 44) versus placebo: P = 0.01; E2 versus E2+P: P = 0.75]. To give a quantitative estimate of the increase, the median change calculated from baseline in both treatment groups together was +87% (P = 0.02) at 4 weeks, and +114% (P = 0.08) at 12 weeks, as compared to the placebo group. Conclusion: In healthy postmenopausal women, short-term treatment with E2 or E2+P was associated with a rapid rise in CRP concentrations. These observations raise the possibility that the increased risk of cardiovascular events is related to an initial increase in CRP levels after starting hormone replacement therapy.

scholarly journals The effects of physical activity during childhood, adolescence, and adulthood on cardiovascular risk factors among adults

2019 ◽  
Vol 65 (11) ◽  
pp. 1337-1342
Author(s):  
André O. Werneck ◽  
Ricardo R. Agostinete ◽  
Manoel Carlos S. de Lima ◽  
Bruna C. Turi-Lynch ◽  
Romulo A. Fernandes
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Body Fat ◽  
Sports Participation ◽  
Lower Body ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Reduced Body

SUMMARY OBJECTIVES: To analyze the association between physical activity during life and cardiovascular risk factors among adults. DESIGN: The sample was composed of 101 adults (59 men) between 30 and 50 years old, who were recruited from different gyms and from a University in Brasil. Participants were divided according to their engagement in sports in early life (self-reported) and current physical activity (pedometer) (sports participation during childhood/adolescence and currently active [n=26], sports participation during childhood/adolescence and currently inactive [n=26], and control [n=49]). Cardiovascular risk factors were measured, such as body fat (through DXA), HDL-C, triglycerides, HOMA index, systolic blood pressure, diastolic blood pressure, and C-reactive protein. We adopted the covariates of chronological age, sex, alcohol consumption, tobacco, and body mass index. General estimating equations were used, with p<0.05. RESULTS: After the adjustments of the final model, individuals engaged in sports during childhood and adolescence and inactive during adulthood presented lower body fat, when compared to participants persistently inactive (p<0.001). Participants persistently active presented lower body fat (p<0.001) and lower c-reactive protein (p=0.010) when compared to the control group. CONCLUSION: Early sports participation was associated with reduced body fat, and being physically active throughout life was associated with reduced body fat and C-reactive protein.

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