scholarly journals Relationship between Bone Mineral Density Changes and Fracture Risk Reduction in Patients Treated with Strontium Ranelate

2007 ◽  
Vol 92 (8) ◽  
pp. 3076-3081 ◽  
Author(s):  
Olivier Bruyere ◽  
Christian Roux ◽  
Johann Detilleux ◽  
Daniel O. Slosman ◽  
Tim D. Spector ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Femoral Neck ◽  
Outcome Measures ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Vertebral Fractures ◽  
Strontium Ranelate ◽  
Mineral Density ◽  
Nonvertebral Fractures

Abstract Objective: Our objective was to analyze the relationship between bone mineral density (BMD) changes and fracture incidence during 3-yr treatment with strontium ranelate. Patients: Women from the strontium ranelate arm of the Spinal Osteoporosis Therapeutic Intervention study and the TReatment Of Peripheral OSteoporosis study were evaluated. Outcome Measures: The outcome measures included BMD at the lumbar spine, femoral neck, and total proximal femur assessed at baseline and after a follow-up of 1 and 3 yr; semiquantitative visual assessment of vertebral fractures; and nonvertebral fractures based on written documentation. Results: After 3 yr of strontium ranelate treatment, each percentage point increase in femoral neck and total proximal femur BMD was associated with a 3% (95% adjusted confidence interval, 1–5%) and 2% (1–4%) reduction in risk of a new vertebral fracture, respectively. The 3-yr changes in femoral neck and total proximal femur BMD explained 76% and 74%, respectively, of the reduction in vertebral fractures observed during the treatment. Three-year changes in spine BMD were not statistically associated with the incidence of new vertebral fracture (P = 0.10). No significant associations were found between 3-yr changes in BMD and incidence of new nonvertebral fractures, but a trend was found for femoral neck BMD (P = 0.09) and for total proximal femur BMD (P = 0.07). An increase in femoral neck BMD after 1 yr was significantly associated with the reduction in incidence of new vertebral fractures observed after 3 yr (P = 0.04). Conclusion: During 3-yr strontium ranelate treatment, an increase in femoral neck BMD was associated with a proportional reduction in vertebral fracture incidence.

scholarly journals Heterogeneity of Bone Mineral Density and Fatigue Failure of Human Vertebrae

2012 ◽  
Author(s):  
Yener N. Yeni ◽  
Laila M. Poisson ◽  
Michael J. Flynn
Keyword(s):  
Mechanical Properties ◽  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Bone Mineral ◽  
Vertebral Fractures ◽  
Important Determinant ◽  
Fatigue Properties ◽  
Static Properties ◽  
Mineral Density ◽  
Significant Interest

Bone qualities that are measurable via clinically available modalities and that can explain fracture risk beyond what is explainable by bone mineral density (BMD) are of significant interest. Evidence from literature suggests that the heterogeneity of BMD within a vertebra, in addition to the average BMD, may be an important determinant of the mechanical properties of a vertebra 1–3 and risk of a clinical vertebral fracture 4. Much of the experimental evidence comes from tests, in which vertebrae are monotonically loaded and relates BMD heterogeneity to the quasi-static properties of a vertebra 1, 3. The appearance of clinical vertebral fractures is in the form of progressive deformities indicating that fatigue processes are involved. However, the relationships between BMD heterogeneity and fatigue properties of a vertebra are not well-understood.

scholarly journals Mechanical torque measurement in the proximal femur correlates to failure load and bone mineral density ex vivo

2013 ◽  
Vol 5 (2) ◽  
pp. 16 ◽  
Author(s):  
Stefan Grote ◽  
Tatjana Noeldeke ◽  
Michael Blauth ◽  
Wolf Mutschler ◽  
Dominik Bürklein
Keyword(s):  
Bone Mineral Density ◽  
Femoral Neck ◽  
Bone Quality ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Failure Load ◽  
Peak Torque ◽  
Mineral Density ◽  
Local Bone ◽  
Load To Failure

Knowledge of local bone quality is essential for surgeons to determine operation techniques. A device for intraoperative measurement of local bone quality has been developed by the AO-Research Foundation (DensiProbe®). We used this device to experimentally measure peak breakaway torque of trabecular bone in the proximal femur and correlated this with local bone mineral density (BMD) and failure load. Bone mineral density of 160 cadaver femurs was measured by <em>ex situ </em>dual-energy X-ray absorptiometry. The failure load of all femurs was analyzed by side-impact analysis. Femur fractures were fixed and mechanical peak torque was measured with the DensiProbe® device. Correlation was calculated whereas correlation coefficient and significance was calculated by Fisher’s Z-transformation. Moreover, linear regression analysis was carried out. The unpaired Student’s t-test was used to assess the significance of differences. The Ward triangle region had the lowest BMD with 0.511 g/cm2 (±0.17 g/cm2), followed by the upper neck region with 0.546 g/cm2 (±0.16 g/cm2), trochanteric region with 0.685 g/cm2 (±0.19 g/cm2) and the femoral neck with 0.813 g/cm2 (±0.2 g/cm2). Peak torque of DensiProbe® in the femoral head was 3.48 Nm (±2.34 Nm). Load to failure was 4050.2 N (±1586.7 N). The highest correlation of peak torque measured by Densi Probe® and load to failure was found in the femoral neck (r=0.64, P&lt;0.001). The overall correlation of mechanical peak torque with T-score was r=0.60 (P&lt;0.001). A correlation was found between mechanical peak torque, load to failure of bone and BMD <em>in vitro</em>. Trabecular strength of bone and bone mineral density are different aspects of bone strength, but a correlation was found between them. Mechanical peak torque as measured may contribute additional information about bone strength, especially in the perioperative testing.

Bone mineral density behavior of proximal femur in women with vertebral fractures

1996 ◽  
Vol 6 (S1) ◽  
pp. 181-181
Author(s):  
E. Kokkinakis ◽  
D. Hadjidakis ◽  
C. Sotiropoulos ◽  
M. Sfakianakis ◽  
S. A. Raptis
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Vertebral Fractures ◽  
Mineral Density ◽  
Density Behavior

Vertebral Fracture Risk Is Reduced for Women Who Lose Femoral Neck Bone Mineral Density During Teriparatide Treatment

2008 ◽  
Vol 11 (3) ◽  
pp. 465 ◽  
Author(s):  
Nelson B. Watts ◽  
Paul D. Miller ◽  
Robert Marcus ◽  
Peiqi Chen ◽  
Jody Arsenault ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Femoral Neck ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Mineral Density ◽  
Teriparatide Treatment ◽  
Vertebral Fracture Risk

Investigation of the Effect of Bone Mineral Density on the Postoperative Outcome of Ankle Fractures in Elderly Patients

2021 ◽  
pp. 107110072199626
Author(s):  
Young Hwan Park ◽  
Hyun Woo Cho ◽  
Jung Woo Choi ◽  
Hak Jun Kim
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Elderly Patients ◽  
Outcome Measures ◽  
Bone Mineral ◽  
Postoperative Outcome ◽  
Ankle Fractures ◽  
Mineral Density ◽  
T Score

Background: The association between ankle fractures in elderly patients and low bone mineral density (BMD) has recently been recognized, but the effect of BMD on the postoperative outcome of these fractures is unknown. The aim of this study was to investigate the effect of BMD on the postoperative outcome of ankle fractures in elderly patients to evaluate the need for BMD screening. Methods: We retrospectively reviewed 48 patients aged 65 years or older who had ankle fractures and underwent dual-energy x-ray absorptiometry to assess BMD after surgical treatment of the fracture. Postoperative outcomes were assessed using the Olerud-Molander Ankle Score (OMAS), visual analog scale (VAS) score for pain, Kellgren and Lawrence (K&L) grading scale score, and quality of fracture reduction. The correlation between the BMD and the outcome measures at 12 months after surgery was analyzed using the Pearson correlation coefficient. Results: The mean absolute value of BMD was 0.6 ± 0.1 g/cm2 (T-score, –1.5 ± 1.2) at the femoral neck and 0.8 ± 0.2 g/cm2 (T-score, –1.2 ± 1.5) at the lumbar spine. Osteoporosis was present in 33% of female patients and in 11% of male patients. At 12 months after surgery, the OMAS was 70 ± 17 and the VAS score for pain was 18 ± 17. Of the patients, 20, 21, 5, 1, and 1 had K&L grades of 0, 1, 2, 3, and 4, respectively. None of the clinical and radiographic outcome measures were correlated with the BMD values of the patients. Conclusion: The postoperative outcome of the ankle fractures in elderly patients at 12 months after surgery showed no correlation with femoral neck or lumbar spine BMD at the time of fracture. Level of Evidence: Level III, retrospective comparative study.

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