Bone mineral density behavior of proximal femur in women with vertebral fractures

1996 ◽  
Vol 6 (S1) ◽  
pp. 181-181
Author(s):  
E. Kokkinakis ◽  
D. Hadjidakis ◽  
C. Sotiropoulos ◽  
M. Sfakianakis ◽  
S. A. Raptis
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Vertebral Fractures ◽  
Mineral Density ◽  
Density Behavior

scholarly journals Relationship between Bone Mineral Density Changes and Fracture Risk Reduction in Patients Treated with Strontium Ranelate

2007 ◽  
Vol 92 (8) ◽  
pp. 3076-3081 ◽  
Author(s):  
Olivier Bruyere ◽  
Christian Roux ◽  
Johann Detilleux ◽  
Daniel O. Slosman ◽  
Tim D. Spector ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Femoral Neck ◽  
Outcome Measures ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Vertebral Fractures ◽  
Strontium Ranelate ◽  
Mineral Density ◽  
Nonvertebral Fractures

Abstract Objective: Our objective was to analyze the relationship between bone mineral density (BMD) changes and fracture incidence during 3-yr treatment with strontium ranelate. Patients: Women from the strontium ranelate arm of the Spinal Osteoporosis Therapeutic Intervention study and the TReatment Of Peripheral OSteoporosis study were evaluated. Outcome Measures: The outcome measures included BMD at the lumbar spine, femoral neck, and total proximal femur assessed at baseline and after a follow-up of 1 and 3 yr; semiquantitative visual assessment of vertebral fractures; and nonvertebral fractures based on written documentation. Results: After 3 yr of strontium ranelate treatment, each percentage point increase in femoral neck and total proximal femur BMD was associated with a 3% (95% adjusted confidence interval, 1–5%) and 2% (1–4%) reduction in risk of a new vertebral fracture, respectively. The 3-yr changes in femoral neck and total proximal femur BMD explained 76% and 74%, respectively, of the reduction in vertebral fractures observed during the treatment. Three-year changes in spine BMD were not statistically associated with the incidence of new vertebral fracture (P = 0.10). No significant associations were found between 3-yr changes in BMD and incidence of new nonvertebral fractures, but a trend was found for femoral neck BMD (P = 0.09) and for total proximal femur BMD (P = 0.07). An increase in femoral neck BMD after 1 yr was significantly associated with the reduction in incidence of new vertebral fractures observed after 3 yr (P = 0.04). Conclusion: During 3-yr strontium ranelate treatment, an increase in femoral neck BMD was associated with a proportional reduction in vertebral fracture incidence.

scholarly journals Vertebral Fractures Occur Regardless of Acromegaly Activity and Are Best Predicted by Proximal Femur Cortical Volumetric Bone Mineral Density

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A638-A638
Author(s):  
Martin Kuzma ◽  
Peter Vanuga ◽  
Ivana Sagova ◽  
Dusan Pavai ◽  
Peter Jackuliak ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Glucose Metabolism ◽  
Trabecular Bone ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Vertebral Fractures ◽  
Fracture Prediction ◽  
Mineral Density

Abstract Introduction: Vertebral fractures (VFs) in patients with acromegaly are not associated with bone mineral density (BMD) decrease. Previous studies showed impaired trabecular bone parameters among acromegaly patients. However, recent studies suggest that cortical bone could also play a role in VF development. Objective: Evaluate the utility of dual energy x-ray absorptiometry (DXA) BMD and bone structural parameters to determine VF risk among acromegaly patients. Patients and Methods: A single-center two years prospective follow up of acromegaly patients regardless of age, gender, disease activity or associated treatments was conducted. Pituitary hormones, glucose metabolism and bone turnover markers in all subjects were assessed. Each subject had L1-4 spine, femoral neck (FN) and total hip (TH) BMD measured using DXA, and TBS measurement performed ± 7 days from blood sampling. 3D Shaper was used to assess proximal femur trabecular and cortical volumetric (v) BMD, cortical surface (s) BMD and cortical thickness (Cth). VF assessment was performed using the lateral spine imaging IVA™ mode with a Hologic Horizon® densitometer using semi-quantitative approach. Study outcomes were assessed at two time points - baseline and month 24. Results: Seventy subjects (34 M/36F), mean age 55.1 years, including 26 with active disease were studied. After two years a significant decrease in IGF-1 (-30%), osteocalcin (-18%) and TH cortical vBMD (-3%; all p≤0.05) was observed. During follow-up, 13 patients nine of them with controlled disease, developed VF; these patients had greater increase in CTx and decrease in TBS, sBMD, cortical and trabecular vBMD at TH and neck. Multivariate analysis of fracture prediction showed cortical vBMD at TH and neck as best parameters for fracture prediction with AUC 0.766 and 0.774; respectively. TBS was negatively associated with fasting plasma glucose (FPG), HBA1c at each time period. Conclusions: Decrease in cortical vBMD was the most sensitive and specific predictor of incident VF suggesting that cortical bone is involved in fracture development among acromegaly patients. In addition, TBS was strongly negatively associated with glucose metabolism, suggesting glucose intolerance could lead to trabecular bone impairment.

scholarly journals Prevalence and risk factors of low bone mineral density in spondyloarthritis and prevalence of vertebral fractures

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Sandrine Malochet-Guinamand ◽  
Bruno Pereira ◽  
Zuzana Tatar ◽  
Anne Tournadre ◽  
Anna Moltó ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Vertebral Fractures ◽  
Mineral Density ◽  
Low Bone Mineral Density

scholarly journals Heterogeneity of Bone Mineral Density and Fatigue Failure of Human Vertebrae

2012 ◽  
Author(s):  
Yener N. Yeni ◽  
Laila M. Poisson ◽  
Michael J. Flynn
Keyword(s):  
Mechanical Properties ◽  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Bone Mineral ◽  
Vertebral Fractures ◽  
Important Determinant ◽  
Fatigue Properties ◽  
Static Properties ◽  
Mineral Density ◽  
Significant Interest

Bone qualities that are measurable via clinically available modalities and that can explain fracture risk beyond what is explainable by bone mineral density (BMD) are of significant interest. Evidence from literature suggests that the heterogeneity of BMD within a vertebra, in addition to the average BMD, may be an important determinant of the mechanical properties of a vertebra 1–3 and risk of a clinical vertebral fracture 4. Much of the experimental evidence comes from tests, in which vertebrae are monotonically loaded and relates BMD heterogeneity to the quasi-static properties of a vertebra 1, 3. The appearance of clinical vertebral fractures is in the form of progressive deformities indicating that fatigue processes are involved. However, the relationships between BMD heterogeneity and fatigue properties of a vertebra are not well-understood.

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