Initial and Cyclic Recruitment of Ovarian Follicles

Abstract Mammalian ovaries consist of follicles as basic functional units. The total number of ovarian follicles is determined early in life, and the depletion of this pool leads to reproductive senescence. Each follicle develops to either ovulate or, more likely, to undergo degeneration. The dynamics of ovarian follicle development have interested endocrinologists and developmental biologists for many years. With the advent of assisted reproductive techniques in humans, the possibility of regulating follicle development in vivo and in vitro has gained clinical relevance. In this review, we focus upon key branching points during the development of ovarian follicles as well as factors involved in determining the eventual destiny of individual follicles. We discuss inconsistencies in the literature regarding the definitions of follicle recruitment and selection and propose to name the two major steps of follicle development as initial and cyclic recruitment, respectively. Because some of these disparities have arisen due to differences in the animal systems studied, we also compare the development of the ovarian follicles of both humans and rats. We also review the status of knowledge of several puzzling clinical issues that may provide important clues toward unlocking the mechanisms of follicle development.

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Analysis of protein-protein interaction network based on transcriptome profiling of ovine granulosa cells identifies candidate genes in cyclic recruitment of ovarian follicles

Journal of Animal Science and Technology ◽

10.1186/s40781-018-0171-y ◽

2018 ◽

Vol 60 (1) ◽

Cited By ~ 2

Author(s):

Reza Talebi ◽

Ahmad Ahmadi ◽

Fazlollah Afraz

Keyword(s):

Candidate Genes ◽

Protein Interaction ◽

Granulosa Cells ◽

Protein Interaction Network ◽

Interaction Network ◽

Transcriptome Profiling ◽

Ovarian Follicles ◽

Protein Protein Interaction ◽

Cyclic Recruitment ◽

Protein Protein Interaction Network

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The expression of angiotensin and endothelin family members in mature ovarian follicles during periovulatory period after GnRH in the cow

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2006-933024 ◽

2006 ◽

Vol 114 (S 1) ◽

Author(s):

B Berisha ◽

A Miyamoto ◽

H Welter ◽

D Schams ◽

HHD Meyer

Keyword(s):

Family Members ◽

Ovarian Follicles

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THE AUTORADIOGRAPHIC DISTRIBUTION PATTERN AFTER ADMINISTRATION OF DIETHYLSTILBOESTROL COMPARED WITH THAT OF NATURAL OESTROGENS

Acta Endocrinologica ◽

10.1530/acta.0.0430561 ◽

1963 ◽

Vol 43 (4) ◽

pp. 561-570 ◽

Cited By ~ 18

Author(s):

Gösta Bengtsson ◽

Sven Ullberg

Keyword(s):

Distribution Pattern ◽

Adrenal Cortex ◽

Natural Compounds ◽

Ovarian Follicles ◽

Interstitial Tissue ◽

Specific Accumulation ◽

Natural And Synthetic

ABSTRACT The distribution in mice of 14C- and 3H-diethylstilboestrol has been investigated autoradiographically. The results have been compared with those which have been previously reported for natural oestrogens. Many similarities have been demonstrated between the synthetic and natural compounds. Thus a specific accumulation has been observed in the endometrium, the granulosa layer of large ovarian follicles, the adrenal cortex. the interstitial tissue of the testes, and the hypophysis. Natural and synthetic oestrogens differ widely concerning the penetration into and the distribution within the foetus.

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