scholarly journals The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement

2012 ◽  
Vol 33 (3) ◽  
pp. 456-492 ◽  
Author(s):  
Clifford J. Rosen ◽  
John S. Adams ◽  
Daniel D. Bikle ◽  
Dennis M. Black ◽  
Marie B. Demay ◽  
...  
Keyword(s):  
Vitamin D ◽  
Endocrine Society ◽  
Scientific Statement

Vitamin D Treatment in Patients with Hashimoto’s Thyroiditis may Decrease the Development of Hypothyroidism

2016 ◽  
Vol 86 (1-2) ◽  
pp. 9-17 ◽  
Author(s):  
Bekir Ucan ◽  
Mustafa Sahin ◽  
Muyesser Sayki Arslan ◽  
Nujen Colak Bozkurt ◽  
Muhammed Kizilgul ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Hashimoto’S Thyroiditis ◽  
Healthy Control Group ◽  
Hashimoto's Thyroiditis ◽  
Control Group ◽  
Endocrine Society ◽  
Thyroid Autoantibody ◽  
Healthy Control ◽  
The Mean

Abstract.The relationship between Hashimoto’s thyroiditis and vitamin D has been demonstrated in several studies. The aim of the present study was to evaluate vitamin D concentrations in patients with Hashimoto’s thyroiditis, the effect of vitamin D therapy on the course of disease, and to determine changes in thyroid autoantibody status and cardiovascular risk after vitamin D therapy. We included 75 patients with Hashimoto’s thyroiditis and 43 healthy individuals. Vitamin D deficiency is defined as a 25-hydroxy vitamin D (25(OH)D3) concentration less than 20ng/mL. Vitamin D deficient patients were given 50.000 units of 25(OH)D3 weekly for eight weeks in accordance with the Endocrine Society guidelines. All evaluations were repeated after 2 months of treatment. Patients with Hashimoto’s thyroiditis had significantly lower vitamin D concentrations compared with the controls (9.37±0.69 ng/mL vs 11.95±1.01 ng/mL, p < 0.05, respectively). Thyroid autoantibodies were significantly decreased by vitamin D replacement treatment in patients with euthyroid Hashimoto’s thyroiditis. Also, HDL cholesterol concentrations improved in the euthyroid Hashimoto group after treatment. The mean free thyroxine (fT4) concentrations were 0.89±0.02 ng/dL in patients with Hashimoto’s thyroiditis and 1.07±0.03 ng/dL in the healthy control group (p < 0.001). The mean thyroid volumes were 7.71±0.44 mL in patients with Hashimoto’s thyroiditis and 5.46±0.63 mL in the healthy control group (p < 0.01). Vitamin D deficiency is frequent in Hashimoto’s thyroiditis and treatment of patients with this condition with Vitamin D may slow down the course of development of hypothyroidism and also decrease cardiovascular risks in these patients. Vitamin D measurement and replacement may be critical in these patients.

scholarly journals Vitamin D Status and Components of Metabolic Syndrome in Older Subjects from Northern Finland (Latitude 65°North)

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1229 ◽  
Author(s):  
Shivaprakash Jagalur Mutt ◽  
Jari Jokelainen ◽  
Sylvain Sebert ◽  
Juha Auvinen ◽  
Marjo-Riitta Järvelin ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Dietary Habits ◽  
Lifestyle Factors ◽  
Vitamin D Status ◽  
Endocrine Society ◽  
Northern Latitudes ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Older Subjects

Introduction: Vitamin D deficiency has been linked to the increased risk of several chronic diseases, especially in people living in the Northern Latitudes. The aim of this study was to assess the vitamin D status in older subjects born in 1945 in Northern Finland (latitude 65°North), and to examine its associations to components of metabolic syndrome (MetS). Methods: In this cross-sectional study, we invited 904 subjects born in 1945 from the Oulu region (Oulu45 cohort), out of an original cohort of 1332 subjects. In the cohort, plasma 25 hydroxyvitamin D (25OHD) levels were determined by an enzyme immunoassay of 263 men and 373 women, with a mean age baseline of 69±0.5 years old. We assessed the participants’ usage of vitamin D supplements, as well as their lifestyle factors, using a questionnaire. Results: Nearly 80% of the subjects had low vitamin D levels [either vitamin D deficient (<50 nmol/L) or insufficient (50 – 75 nmol/L)], and only 20% of the participants had sufficient vitamin D levels (>75 nmol/L) (based on the American Endocrine Society guidelines). The low vitamin D status was associated with a high prevalence of MetS; a significantly higher number of subjects with MetS (41%) had low vitamin D levels in comparison to the non-MetS subjects (38%) (p ≤ 0.05). The subjects under vitamin D supplementation had a significantly lower incidence of MetS (42.6% vs 57.4%) and its components in comparison to the non-supplemented subjects (p ≤ 0.05). Conclusions: Low vitamin D levels are a risk factor for MetS amongst other lifestyle factors, such as dietary habits and physical inactivity, among older subjects in the Northern Latitudes (65°North). Optimal supplementation of vitamin D, along with rich dietary sources of vitamin D, are highly recommended for older subjects as a means to positively affect, e.g., hypertension, insulin resistance, and obesity, as components of the MetS.

scholarly journals Health Disparities in Endocrine Disorders: Biological, Clinical, and Nonclinical Factors—An Endocrine Society Scientific Statement

2012 ◽  
Vol 97 (9) ◽  
pp. E1579-E1639 ◽  
Author(s):  
Sherita Hill Golden ◽  
Arleen Brown ◽  
Jane A. Cauley ◽  
Marshall H. Chin ◽  
Tiffany L. Gary-Webb ◽  
...  
Keyword(s):  
Health Disparities ◽  
Endocrine Disorders ◽  
Endocrine Society ◽  
Scientific Statement

scholarly journals Diabetic Microvascular Disease: An Endocrine Society Scientific Statement

2017 ◽  
Vol 102 (12) ◽  
pp. 4343-4410 ◽  
Author(s):  
Eugene J Barrett ◽  
Zhenqi Liu ◽  
Mogher Khamaisi ◽  
George L King ◽  
Ronald Klein ◽  
...  
Keyword(s):  
Microvascular Disease ◽  
Endocrine Society ◽  
Scientific Statement

scholarly journals Screening for Endocrine Hypertension: An Endocrine Society Scientific Statement

2017 ◽  
Vol 38 (2) ◽  
pp. 103-122 ◽  
Author(s):  
William F. Young ◽  
David A. Calhoun ◽  
Jacques W.M. Lenders ◽  
Michael Stowasser ◽  
Stephen C. Textor
Keyword(s):  
Endocrine Society ◽  
Endocrine Hypertension ◽  
Scientific Statement

scholarly journals Diagnosis and management of Paget?s disease of bone

2014 ◽  
Vol 58 (6) ◽  
pp. 587-599 ◽  
Author(s):  
Luiz Griz ◽  
Daniele Fontan ◽  
Patricia Mesquita ◽  
Marise Lazaretti-Castro ◽  
Victoria Zeghbi Cochenski Borba ◽  
...  
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Level Of Evidence ◽  
Mineral Research ◽  
Endocrine Society ◽  
Diagnosis And Management ◽  
Brazilian Society ◽  
Scientific Statement

Objective: To conduct a literature review on the diagnosis and management of Paget’s disease of bone. Materials and methods: This scientific statement was generated by a request from the Brazilian Medical Association (AMB) to the Brazilian Society of Endocrinology and Metabolism (SBEM) as part of its Clinical Practice Guidelines program. Articles were identified by searching in PubMed and Cochrane databases as well as abstracts presented at the Endocrine Society, Brazilian Society for Endocrinology Annual Meetings and the American Society for Bone and Mineral Research Annual Meeting during the last 5 years. Grading quality of evidence and strength of recommendation were adapted from the first report of the Oxford Centre for Evidence-based Medicine. All grades of recommendation, including “D”, are based on scientific evidence. The differences between A, B, C and D, are due exclusively to the methods employed in generating evidence. Conclusion: We present a scientific statement on Paget’s disease of bone providing the level of evidence and the degree of recommendation regarding causes, clinical presentation as well as surgical and medical treatment. Arq Bras Endocrinol Metab. 2014;58(6):587-99

scholarly journals Opinions and Practice of US-Based Obstetrician-Gynecologists regarding Vitamin D Screening and Supplementation of Pregnant Women

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Sara A. Mohamed ◽  
Ayman Al-Hendy ◽  
Jay Schulkin ◽  
Michael L. Power
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Patient Population ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Institute Of Medicine ◽  
Vitamin D Status ◽  
Online Questionnaire ◽  
Endocrine Society ◽  
Hydroxyvitamin D

Vitamin D deficiency/insufficiency is prevalent among pregnant women. Recommendations for adequate levels of circulating 25-hydroxyvitamin D and appropriate vitamin D supplementation during pregnancy differ between the Institute of Medicine and the Endocrine Society. Obstetrician-gynecologists must make clinical decisions in this environment of uncertain guidance. An online questionnaire regarding physician practice patterns for screening and supplementing pregnant women was administered to 225 randomly selected practicing obstetrician-gynecologists of whom 101 (45%) completed the questionnaire. A majority indicated that vitamin D insufficiency was a problem in their patient population (68.4%) and that most of their pregnant patients would benefit from vitamin D supplementation (66.3%). Half (52.5%) would recommend vitamin D supplementation during pregnancy to some patients, but only 16.8% to all. Only one in four (25.8%) routinely screen their pregnant patients for vitamin D status. Physicians who indicated that vitamin D status was a problem in their patient population were more likely to screen routinely (32.8% versus 9.7%,P=0.002) and believe their patients would benefit from supplementation (91.2% versus 16.1%,P=0.001). Opinion regarding supplementation levels and indicators of adequacy were split between the two competing recommendations, suggesting that clinical practice will likely remain variable across physicians, with uncertain public health consequences.

scholarly journals Vitamin D Status and Parathyroid Hormone Levels in Girls With Central Precocious Puberty

2021 ◽  
Author(s):  
Teodoro Durá-Travé ◽  
Fidel Gallinas-Victoriano ◽  
Lotfi Ahmed-Mohamed ◽  
Paula Moreno-González ◽  
María Urretavizcaya-Martinez ◽  
...  
Keyword(s):  
Vitamin D ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Hypovitaminosis D ◽  
Bone Age ◽  
Control Group ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Endocrine Society ◽  
Prepubertal Girls

Abstract The objective of this study was to analyze the vitamin D status and PTH levels in 6- to 8-years-old girls with central precocious puberty. A cross-sectional clinical and blood testing (calcium, phosphorus, 25(OH)D and PTH) were carried out in 78 girls with central precocious puberty (CPP group), aged 6.1-7.9 years. A control group was recruited (157 prepubertal girls, aged 6.1-8.2 years). The criteria of the US Endocrine Society were used for the definition of hypovitaminosis D. There were no significant differences in the vitamin D status between both groups. There were not significant differences in 25(OH)D levels between CPP (25.4±8.6 ng/mL) and control groups (28.2±7.4 ng/mL). In contrast, in CPP group PHT levels (44.8±16.3 pg/mL) were higher (p < 0.05) with respect to control group (31.0±11.9 ng/mL). In CPP group there was positive correlation (p < 0.05) between PTH levels and growth rate, bone age, basal estradiol, basal FSH, basal LH and LH peak. Conclusion: Vitamin D status in 6- to 8-years-old girls with CPP is similar to that in prepubertal girls. PTH levels were significantly higher in girls with CPP, and could be considered as a pubertal characteristic and, in this case, of pubertal precocity.

scholarly journals Validation and Determination of 25(OH) Vitamin D and 3-Epi25(OH)D3 in Breastmilk and Maternal- and Infant Plasma during Breastfeeding

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2271 ◽  
Author(s):  
Jennifer Gjerde ◽  
Marian Kjellevold ◽  
Lisbeth Dahl ◽  
Torill Berg ◽  
Annbjørg Bøkevoll ◽  
...  
Keyword(s):  
Vitamin D ◽  
Plasma Levels ◽  
Maternal Plasma ◽  
Vitamin D Metabolites ◽  
Endocrine Society ◽  
Liquid Chromatography Tandem Mass ◽  
Automated Sample Preparation ◽  
25 Oh Vitamin D ◽  
Accurate Quantification

Vitamin D deficiency in pregnant women and their offspring may result in unfavorable health outcomes for both mother and infant. A 25hydroxyvitamin D (25(OH)D) level of at least 75 nmol/L is recommended by the Endocrine Society. Validated, automated sample preparation and liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were used to determine the vitamin D metabolites status in mother-infant pairs. Detection of 3-Epi25(OH)D3 prevented overestimation of 25(OH)D3 and misclassification of vitamin D status. Sixty-three percent of maternal 25(OH)D plasma levels were less than the recommended level of 25(OH)D at 3 months. Additionally, breastmilk levels of 25(OH)D decreased from 60.1 nmol/L to 50.0 nmol/L between six weeks and three months (p < 0.01). Furthermore, there was a positive correlation between mother and infant plasma levels (p < 0.01, r = 0.56) at 3 months. Accordingly, 31% of the infants were categorized as vitamin D deficient (25(OH)D < 50 nmol/L) compared to 25% if 3-Epi25(OH)D3 was not distinguished from 25(OH)D3. This study highlights the importance of accurate quantification of 25(OH)D. Monitoring vitamin D metabolites in infant, maternal plasma, and breastmilk may be needed to ensure adequate levels in both mother and infant in the first 6 months of infant life.

scholarly journals Vitamin D status of healthy coastal fishermen of Bangladesh

2020 ◽  
Vol 13 (2) ◽  
pp. 35-39
Author(s):  
Wasim Md Mohosin Ul Haque ◽  
Md Faruque Pathan ◽  
MA Sayeed
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Status ◽  
Ipth Level ◽  
Endocrine Society ◽  
Uv Index ◽  
Exposed Population ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Study Population

Background and objectives: Vitamin D deficiency is now a global concern. Industrialization, urbanization and the decreasing participation in outdoor activities, with consequent sunlight deprivation, are thought to be the key factors in the increasing prevalence of vitamin D deficiency among general population of many countries. It is presumed that healthy, adequately sun-exposed people should maintain adequate vitamin D levels. However, studies within this population are scarce. Hence, this study was conducted to find out the actual vitamin D status in healthy, adequately sun-exposed population living in coastal district of Bangladesh. Material and Methods: One hundred and forty healthy fishermen living in costal district of Cox’s Bazar (210 25' North, 910 59' East) of Bangladesh were enrolled in this study. Relevant data and blood samples were collected during August 2018, one of the months with lower zenith angle and higher UV index. Chemiluminescent micro-particle immunoassay (CMIA) was used to measure 25-hydroxy vitamin D3. Other relevant biochemical parameters measured were random blood glucose (RBG), serum creatinine, albumin, calcium, phosphate, alkaline phosphatase and intact parathyroid hormone (iPTH). Results: Mean vitamin D level of the study population was 27.04±7.20 ng/ml. Based on the cut off value of Endocrine Society, 70.7% of the study population had low vitamin D levels of which 26 (18.6%) and 73 (52.1%) were in vitamin D deficient (<20ng/ml) and insufficient (20 – 29.99 ng/ml) categories respectively. Vitamin D level was normal in 41 (29.3%) subjects. There was no significant difference in iPTH level between groups with low and normal vitamin D levels (p>.05, 95%CI= -5.68226, 1.21086). Conclusion: The unexpectedly high prevalence of vitamin D deficiency in this healthy and adequately sun-exposed population raises the question regarding the validity of the current cutoff value being used to assess the vitamin D status of Bangladeshi population. Future studies should be carried out to determine nation-specific, local cutoff values for vitamin D sufficiency. Ibrahim Med. Coll. J. 2019; 13(2): 35-39

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