scholarly journals Tumor Cell-Organ Microenvironment Interactions in the Pathogenesis of Cancer Metastasis

2007 ◽  
Vol 28 (3) ◽  
pp. 297-321 ◽  
Author(s):  
Robert R. Langley ◽  
Isaiah J. Fidler
Keyword(s):  
Tumor Cell ◽  
Cancer Metastasis ◽  
Organ Microenvironment

scholarly journals Eosinophilic inflammation promotes CCL6-dependent metastatic tumor growth

2021 ◽  
Vol 7 (22) ◽  
pp. eabb5943
Author(s):  
Fei Li ◽  
Xufei Du ◽  
Fen Lan ◽  
Na Li ◽  
Chao Zhang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Bone Metastasis ◽  
Tumor Cell ◽  
Cancer Metastasis ◽  
Inflammatory Diseases ◽  
Metastatic Tumor ◽  
Eosinophil Infiltration ◽  
Tumor Cell Migration ◽  
Promote Tumor Cell ◽  
Chemokine Ligand

Compelling evidence suggests that inflammatory components contribute to cancer development. However, eosinophils, involved in several inflammatory diseases, were not fully explored in cancer metastasis. We show that airway inflammatory eosinophilia and colonic inflammation with eosinophil infiltration are both associated with increased metastasis in mice. Eosinophilia is responsible for increased bone metastasis in eosinophil-enriched Cd3δ-Il-5 transgenic (Il-5 Tg) mice. We also observe increased eosinophils in the malignant pleural effusion of cancer patients with pleural metastasis. Mechanistically, eosinophils promote tumor cell migration and metastasis formation through secreting C-C motif chemokine ligand 6 (CCL6). Genetic knockout of Ccl6 in Il-5 Tg mice remarkably attenuates bone metastasis. Moreover, inhibition of C-C chemokine receptor 1 (CCR1, the receptor of CCL6) in tumor cells reduces tumor cell migration and metastasis. Thus, our study identifies a CCL6-dependent prometastatic activity of eosinophils, which can be inhibited by targeting CCR1 and represent an approach to preventing metastatic disease.

Abstract IA3: Normalizing tumor cell metabolism in breast cancer metastasis: A novel therapeutic approach

2013 ◽  
Author(s):  
Antonio F. Santidrian ◽  
Akemi Matsuno-Yagi ◽  
Melissa Ritland ◽  
Byoung B. Seo ◽  
Sarah E. LeBoeuf ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cell ◽  
Therapeutic Approach ◽  
Cancer Metastasis ◽  
Cell Metabolism ◽  
Breast Cancer Metastasis ◽  
Tumor Cell Metabolism ◽  
Novel Therapeutic

scholarly journals Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis

2010 ◽  
Vol 9 (1) ◽  
pp. 206 ◽  
Author(s):  
Pawan Kumar ◽  
Arti Yadav ◽  
Samip N Patel ◽  
Mozaffarul Islam ◽  
Quintin Pan ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Tumor Cell ◽  
Cell Motility ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Metastasis ◽  
Tumor Cell Motility

Model Simulations Reveal VCAM-1 Augment PAK Activation Rates to Amplify p38 MAPK and VE-Cadherin Phosphorylation

2012 ◽  
Author(s):  
Eric Weidert ◽  
Payal Khanna ◽  
Francisco Vital-Lopez ◽  
Cheng Dong
Keyword(s):  
Endothelial Cells ◽  
Tumor Cell ◽  
Adhesion Molecules ◽  
Cancer Metastasis ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Melanoma Cancer ◽  
Mitogen Activated Protein ◽  
Late Antigen ◽  
Cancer Tumor

Metastasis is a complex process mediated by both adhesion molecules and chemokine secretion [1]. One important event during cancer metastasis is tumor cell extravasation through the endothelium [1]. In melanoma cancer, tumor cell extravasation is mediated by very late antigen (VLA)-4 molecule adhesion to vascular cell adhesion molecules (VCAM)-1 on endothelial cells [2]. High expression levels of VLA-4 integrin are associated with a marked increase in melanoma extravasation through endothelial layers [2]. The binding of VLA-4 to VCAM -1 induces the activation of downstream mitogen activated protein kinase (MAPK) signaling cascades, which regulate the vascular endothelial (VE)-cadherin junctions that hold together endothelial cells [2].

scholarly journals Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

2015 ◽  
Vol 125 (4) ◽  
pp. 1648-1664 ◽  
Author(s):  
Wies van Roosmalen ◽  
Sylvia E. Le Dévédec ◽  
Ofra Golani ◽  
Marcel Smid ◽  
Irina Pulyakhina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Tumor Cell ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Tumor Cell Migration

Abstract A21: microRNA-200 regulates tumor cell PD-L1 expression to control lung cancer metastasis.

2014 ◽  
Vol 20 (2 Supplement) ◽  
pp. A21-A21
Author(s):  
Don L. Gibbons ◽  
Limo Chen ◽  
Sangeeta Goswami ◽  
Young-Ho Ahn ◽  
Lauren A. Byers ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Cancer Metastasis ◽  
Lung Cancer Metastasis
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