scholarly journals Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

2015 ◽  
Vol 125 (4) ◽  
pp. 1648-1664 ◽  
Author(s):  
Wies van Roosmalen ◽  
Sylvia E. Le Dévédec ◽  
Ofra Golani ◽  
Marcel Smid ◽  
Irina Pulyakhina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Tumor Cell ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Tumor Cell Migration

scholarly journals CXCR3 as a molecular target in breast cancer metastasis: inhibition of tumor cell migration and promotion of host anti-tumor immunity

Oncotarget ◽  
2015 ◽  
Vol 6 (41) ◽  
pp. 43408-43419 ◽  
Author(s):  
Guiquan Zhu ◽  
H. Hannah Yan ◽  
Yanli Pang ◽  
Jiang Jian ◽  
Bhagelu R. Achyut ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Tumor Cell ◽  
Tumor Immunity ◽  
Cancer Metastasis ◽  
Molecular Target ◽  
Breast Cancer Metastasis ◽  
Tumor Cell Migration ◽  
Metastasis Inhibition

scholarly journals Eosinophilic inflammation promotes CCL6-dependent metastatic tumor growth

2021 ◽  
Vol 7 (22) ◽  
pp. eabb5943
Author(s):  
Fei Li ◽  
Xufei Du ◽  
Fen Lan ◽  
Na Li ◽  
Chao Zhang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Bone Metastasis ◽  
Tumor Cell ◽  
Cancer Metastasis ◽  
Inflammatory Diseases ◽  
Metastatic Tumor ◽  
Eosinophil Infiltration ◽  
Tumor Cell Migration ◽  
Promote Tumor Cell ◽  
Chemokine Ligand

Compelling evidence suggests that inflammatory components contribute to cancer development. However, eosinophils, involved in several inflammatory diseases, were not fully explored in cancer metastasis. We show that airway inflammatory eosinophilia and colonic inflammation with eosinophil infiltration are both associated with increased metastasis in mice. Eosinophilia is responsible for increased bone metastasis in eosinophil-enriched Cd3δ-Il-5 transgenic (Il-5 Tg) mice. We also observe increased eosinophils in the malignant pleural effusion of cancer patients with pleural metastasis. Mechanistically, eosinophils promote tumor cell migration and metastasis formation through secreting C-C motif chemokine ligand 6 (CCL6). Genetic knockout of Ccl6 in Il-5 Tg mice remarkably attenuates bone metastasis. Moreover, inhibition of C-C chemokine receptor 1 (CCR1, the receptor of CCL6) in tumor cells reduces tumor cell migration and metastasis. Thus, our study identifies a CCL6-dependent prometastatic activity of eosinophils, which can be inhibited by targeting CCR1 and represent an approach to preventing metastatic disease.

scholarly journals E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Daniel P. Hollern ◽  
Matthew R. Swiatnicki ◽  
Jonathan P. Rennhack ◽  
Sean A. Misek ◽  
Brooke C. Matson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Target Gene ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis

Abstract IA3: Normalizing tumor cell metabolism in breast cancer metastasis: A novel therapeutic approach

2013 ◽  
Author(s):  
Antonio F. Santidrian ◽  
Akemi Matsuno-Yagi ◽  
Melissa Ritland ◽  
Byoung B. Seo ◽  
Sarah E. LeBoeuf ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cell ◽  
Therapeutic Approach ◽  
Cancer Metastasis ◽  
Cell Metabolism ◽  
Breast Cancer Metastasis ◽  
Tumor Cell Metabolism ◽  
Novel Therapeutic
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