scholarly journals The Circadian Clock, Shift Work, and Tissue-Specific Insulin Resistance

Endocrinology ◽  
2020 ◽  
Vol 161 (12) ◽  
Author(s):  
Johanneke E Oosterman ◽  
Suzan Wopereis ◽  
Andries Kalsbeek
Keyword(s):  
Insulin Resistance ◽  
Eating Behavior ◽  
Shift Work ◽  
Glucose Homeostasis ◽  
Biological Clock ◽  
The Body ◽  
Health Concern ◽  
Phenotypic Flexibility ◽  
Increased Risk ◽  
Eating Out

Abstract Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of obesity and T2D is significantly higher in shift workers compared to people working regular hours. An accepted hypothesis is that the increased risk for metabolic health problems arises from aberrantly timed eating behavior, that is, eating out of synchrony with the biological clock. The biological clock is part of the internal circadian timing system, which controls not only the sleep/wake and feeding/fasting cycle, but also many metabolic processes in the body, including the timing of our eating behavior, and processes involved in glucose homeostasis. Rodent studies have shown that eating out of phase with the endogenous clock results in desynchronization between rhythms of the central and peripheral clock systems and between rhythms of different tissue clocks (eg, liver and muscle clock). Glucose homeostasis is a complex process that involves multiple organs. In the healthiest situation, functional rhythms of these organs are synchronized. We hypothesize that desynchronization between different metabolically active organs contributes to alterations in glucose homeostasis. Here we summarize the most recent information on desynchronization between organs due to shift work and shifted food intake patterns and introduce the concept of phenotypic flexibility, a validated test to assess the contribution of each organ to insulin resistance (IR) in humans. We propose this test as a way to provide further insight into the possible desynchronization between tissue clocks. Because different types of IR benefit from different therapeutic approaches, we also describe different chronotherapeutic strategies to promote synchrony within and between metabolically active organs.

scholarly journals Correlation of Prolonged Total Ischemic Time with Body Mass Index in Kidney Transplant: A Single Center Report

2021 ◽  
Vol 5 (11) ◽  
pp. 1009-1013
Author(s):  
Eriawan Agung Nugroho ◽  
Erwin Wibowo ◽  
Prathita Amanda Aryani
Keyword(s):  
Body Mass Index ◽  
Kidney Transplantation ◽  
Kidney Transplant ◽  
Body Mass ◽  
The Body ◽  
Health Concern ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Ischemic Time ◽  
Increased Risk

Background: Chronic kidney disease (CKD) is a rising health concern worldwide, especially in Indonesia. The treatment of choice for end-stage renal disease is Kidney Transplantation.1 Numerous studies showed that prolonged total ischemic ischemic time may cause hypoxia of the graft tissue and increased risk of ischemia and reperfusion injury (IRI) and delayed graft function (DGF).2 Body mass index of kidney transplant recipients may cause prolonged duration of the procedure, as well as prolonged total ischemic time. This study aimed to determine the correlation between prolonged total ischemic time with body mass index. Method: This was an observational and cross-sectional analysis at Kariadi General Hospital Semarang involving patients who underwent kidney transplantation from January 2016 to December 2019. The total ischemic time was recorded intraoperatively. The Body Mass Index data were provided by medical records. The program used to statistically analyze the data was SPSS 23.0, and Spearman was used for hypothesis testing. Result: This study included 25 kidney transplant recipients. The mean total ischemic time was 43,27 ± 6,63 minutes. There was a significant positive correlation between prolonged ischemic time and body mass index (r= 0,506 ; p= 0,010). Conclusion: Prolonged total ischemic time was positively correlated with increased body mass index and these results are statistically significant.

scholarly journals Nutrition Knowledge is Associated With the Consumption of Iron Rich Foods: A Survey Among Pregnant Women From a Rural District in Northern Ghana

2021 ◽  
Vol 14 ◽  
pp. 117863882110394
Author(s):  
Nhyira Yaw Adjei-Banuah ◽  
Victor Abugah Aduah ◽  
Shamsu-Deen Ziblim ◽  
Martin Amogre Ayanore ◽  
Anthony Amalba ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anaemia ◽  
Nutrition Knowledge ◽  
The Body ◽  
Rural District ◽  
Leafy Vegetables ◽  
Health Concern ◽  
Deficiency Anaemia ◽  
Increased Risk

Introduction: Iron deficiency anaemia is an international public health concern and pregnant women are at an increased risk. We investigated the consumption of iron rich foods and associated factors among pregnant women in a rural district from Ghana. Methods: Following a cross-sectional design, dietary intake of iron rich foods was obtained from 252 pregnant women using a 24-hour recall food check list. Nutrition knowledge, attitudes and socio-demographic characteristics were also assessed. Findings: Participants had a mean (SD) knowledge score of 54.66 (22.74)%. About 73% of the participants had heard about iron-deficiency anaemia. Only 16.3% of the participants knew foods that help the body to absorb and use iron while 9.1% knew beverages that decrease iron absorption. About 71% of the participants ate fish and/or seafood while 67.1% of them ate green leafy vegetables. Only 4.4% of the participants ate organ meat, and 29% took flesh meat. Only 22.4% of the study participants usually drank coffee or tea while 78.2% ate vitamin C-rich foods. With regards to attitudes, 88.5% of the participants perceived anaemia to be a serious disease. Nutrition knowledge was significantly associated with the consumption of iron rich foods (β = .02; 95% CI = 0.01-0.02). Conclusion: Nutrition knowledge may be an important determinant of the consumption of iron rich foods among pregnant women making it necessary for healthcare providers to continue to provide nutrition education to pregnant women during routine antenatal care.

scholarly journals Poor zinc status is associated with increased risk of insulin resistance in Spanish children

2011 ◽  
Vol 107 (3) ◽  
pp. 398-404 ◽  
Author(s):  
R. M. Ortega ◽  
E. Rodríguez-Rodríguez ◽  
A. Aparicio ◽  
A. I. Jiménez ◽  
A. M. López-Sobaler ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Inverse Correlation ◽  
The Body ◽  
Zn Deficiency ◽  
Model Assessment ◽  
Food Record ◽  
Zn Concentration ◽  
Increased Risk ◽  
Serum Zn ◽  
Zn Status

Zn plays a key role in the synthesis and action of insulin. The aim of the present work was to determine whether a poorer Zn status was associated with insulin resistance in a group of 357 Spanish schoolchildren. Zn intake was determined by using a 3 d food record (i.e. Sunday to Tuesday). The body weight, height and waist and hip circumferences of all subjects were recorded and fasting plasma glucose, insulin and Zn concentrations were determined. Insulin resistance was determined using the homoeostasis model assessment (HOMA) marker. Children (11·5 %) with Zn deficiency (serum Zn concentration < 10·7 μmol/l) had higher HOMA values than those with a more satisfactory Zn status (1·73 (sd0·93)) compared with 1·38 (sd0·90;P < 0·05). An inverse correlation was found between the HOMA value and the serum Zn concentration (r− 0·149,P < 0·05). The risk of having a greater insulin resistance value (HOMA greater than the 75th percentile) increased with age (OR 1·438; 95 % CI 1·021, 2·027) and BMI (OR 1·448; 95 % CI 1·294, 1·619) and decreased as Zn serum levels increased (OR 0·908; 95 % CI 0·835, 0·987;P < 0·001). Moreover, an inverse relationship was observed between HOMA values and Zn dietary density (r− 0·122), and the Zn intakes of male children with a HOMA value of >3·16 made a significantly smaller contribution to the coverage of those recommended (59·7 (sd14·7) %) than observed in children with lower HOMA values (73·6 (sd18·2) %;P < 0·05). Taking into account that Zn intake was below than that recommended in 89·4 % of the children, it would appear that increasing the intake of Zn could improve the health and nutritional status of these children, and thus contribute to diminish problems of insulin resistance.

scholarly journals Body mass index, shift work and food consumption: what relationship?

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
Carolina Morgado ◽  
João Lima
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Shift Work ◽  
Online Survey ◽  
Negative Influence ◽  
The Body ◽  
Fruit And Vegetables ◽  
Work Schedule ◽  
Shift Workers ◽  
Increased Risk

Abstract Background A significant percentage of the population is working on shift work and according to several studies this type of work schedule has been associated with an increased risk of developing some pathologies, such as obesity, which are one of the biggest mortality causes in the world. To understand if the shift work has a negative influence on the workers' diet and if it affects the Body Mass Index. Methods Observational and cross-sectional research was conducted, through an online survey designed for this purpose, including fruit and vegetables consumption, sociodemographic characteristics, shift work schedule, sleep hours and reported values of weight and height. The study was ethical approval and statistical analysis was performed using the IBM SPSS Statistics software. A critical significance level of 5% was considered. Results 145 workers were evaluated with an average age of 35.90 ± 10.92 years and an average Body Mass Index of 25.12 ± 4.54 kg/m2, 76.6% were female. 51.7% of the individuals worked on shift work. Body Mass Index of shift workers is higher than Body Mass Index day shift workers (P = 0.001), and they sleep, on average, less hours than day workers. No differences was observed related to fruit and vegetables consumptions. Shift workers reported to have higher difficult to management food intake when compared with day workers (P &lt; 0.001). Conclusions Shift work seems to have a negative influence on the workers' sleep and in Body Mass Index. This study is important to develop, in the future, individualized strategies, for these workers

scholarly journals MICRONUTRIENT DEFICIENCY IN THE PATHOGENESIS OF INSULIN RESISTANCE AND WAYS TO CORRECT IT

2021 ◽  
Vol 78 (4) ◽  
pp. 135-145
Author(s):  
Myroslava Mykytyuk
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Mediterranean Diet ◽  
Micronutrient Deficiency ◽  
The Body ◽  
Omega 3 ◽  
Increased Risk

The review discusses modern views on the pathogenesis of insulin resistance (IR), in particular the role of micronutrient deficiency. The spread of IR in various somatic pathologies indicates an adaptive IR value not only for glucose homeostasis disorders, but also for metabolism in the body as a whole. A promising area of therapy for IR and cardiovascular diseases closely related to obesity and metabolic syndrome (MS) is the use of modulators of products by the human body of endogenous regulatory factors based on omega-3 polyunsaturated fatty acids. The American Diabetic Association supports adherence to a Mediterranean diet enriched with omega-3 polyunsaturated fatty acids. A meta-analysis of 50 clinical, prospective and cross-examination studies has proven the positive protection effect of the Mediterranean diet on MS components. The development of IR can be associated with a deficiency of chromium and magnesium, and the additional intake of these trace elements with nutritional supplements reduces the severity of IR. Pancreatic β-cell dysfunction, IR, increased risk of MS and type 2 diabetes associated with hypomagnemia. It has been shown that the combination of oral food additives chromium (160 icg/day) and magnesium (200 mg/day) reduces IR more effectively than their use separately, which may be associated with increased induction and repression, respectively, the expression of glucose transporter 4 and glycogen-synthase kinase 3. Thus, micronutrients can be used in complex therapy of patients with IR and associated pathological conditions, such as excess body weight/obesity, type 2 diabetes and MS.

scholarly journals Is Nitric oxide the missing link in glucose homeostasis? A study on correlation of Nitric oxide and Insulin Resistance in Obstructive Sleep Apnoea

2019 ◽  
Vol 10 (2) ◽  
pp. 820-825
Author(s):  
Ramya K ◽  
Gowri Sethu ◽  
Dhanasekar T
Keyword(s):  
Nitric Oxide ◽  
Insulin Resistance ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Glucose Homeostasis ◽  
Reciprocal Relationship ◽  
Control Group ◽  
Group I ◽  
Obstructive Sleep ◽  
Increased Risk

Nitric oxide is associated with glucose homeostasis. An independent relationship between Nitric oxide and insulin resistance in Prediabetic and Obstructive sleep apnea patients without pre-existing diabetes mellitus are equivocally linked to increased risk of type II diabetes. A reciprocal relationship seems to exist between nitric oxide and insulin resistance. Aim of this present study is to determine relationship between nitric oxide and glucose parameters in control, prediabetic and Obstructive sleep apnea. A cross sectional study was performed in 150. They were divided into, group I (control), group II (prediabetics) and group III (OSA). Fasting blood sugar (FBS), fasting insulin, HbA1c and nitric oxide were measured in these subjects and insulin resistance calculated by HOMA-IR. Data was analyzed statistically using Pearson’s correlation coefficient analysis, the significant value being P<0.05. Negative correlation was observed between the NO and insulin resistance in prediabetic (r=-0.627, P =<0.001) and OSA (r= -0.416, P=0.003) respectively. Nitric oxide is significantly inversely associated with insulin resistance in Prediabetic and Obstructive sleep apnea.

scholarly journals Effects of Irregular Shifts on Incidence of Type II Diabetes Among Healthcare Workers

2020 ◽  
Vol 3 ◽  
Author(s):  
Varun Rameswara ◽  
Amy Blevins ◽  
George Eckert ◽  
Denis Jusufbegovic ◽  
Ashay Bhatwadekar
Keyword(s):  
Systematic Review ◽  
Insulin Resistance ◽  
Shift Work ◽  
Healthcare Workers ◽  
Data Extraction ◽  
Rapid Review ◽  
Glucose Metabolism Disorders ◽  
Work Schedule ◽  
Shift Workers ◽  
Increased Risk

Background/Objective:  The prevalence of shift work ranges around 20% among American and European workers and is significantly higher in the healthcare field. Variable work schedules among shift workers are associated with adverse health effects, including the increased risk of metabolic disorders and obesity. This systematic review aims to evaluate the association between shift work and type 2 diabetes/insulin resistance.    Methods:  This research is part of a more extensive systematic review that has been registered on Prospero. Due to time constraints, we began with a scoping search with the goal of completing a rapid review. Searches were completed using the Ovid and PubMed databases with the following keywords and subject headings: Health Personnel; Shift Work Schedule; Circadian Rhythm; Work Schedule Tolerance; Metabolic Diseases; Overweight; Glucose Metabolism Disorders; Lipid Metabolism Disorders; Malabsorption Syndromes; Metabolic Syndrome; and Diabetes Mellitus. The resulting articles were uploaded onto Covidence for screening and data extraction. After screening the abstracts for diabetes and insulin resistance, eight articles were selected for the full-text screening of which data extraction was performed on three.    Results:  Overall, 163,555 participants performing evening, night, rotating shifts, or regular shifts were identified in the three studies. The average age of study participants was found to be 44.0 yrs,  163,422 were females (>99.9%), and of the total participants, 98,303 subjects were shift workers (60.10%). For healthcare shift workers, there was a significant association between shift work and diabetes across all three studies; however, the effect was modest (relative risk in the range of 1.19-1.26).       Conclusion:  There is a positive relationship between shift work and diabetes among healthcare workers. Therefore, strategies focusing on reducing shift work or treating these workers as a high-risk group for diabetes by taking measures to minimize other exposures will be beneficial in reducing the incidence of diabetes among this population. 

scholarly journals Correlation of Prolonged Total Ischemic Time with Body Mass Index in Kidney Transplant: A Single Center Report

2021 ◽  
Vol 5 (4) ◽  
pp. 919-924
Author(s):  
Eriawan Agung Nugroho ◽  
Erwin Wibowo ◽  
Prathita Amanda Aryani
Keyword(s):  
Body Mass Index ◽  
Kidney Transplantation ◽  
Kidney Transplant ◽  
Body Mass ◽  
The Body ◽  
Health Concern ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Ischemic Time ◽  
Increased Risk

Background: Chronic kidney disease (CKD) is a rising health concern worldwide, especially in Indonesia. The treatment of choice for end-stage renal disease is Kidney Transplantation.1 Numerous studies showed that prolonged total ischemic ischemic time may cause hypoxia of the graft tissue and increased risk of ischemia and reperfusion injury (IRI) and delayed graft function (DGF).2 Body mass index of kidney transplant recipients may cause prolonged duration of the procedure, as well as prolonged total ischemic time. This study aimed to determine the correlation between prolonged total ischemic time with body mass index. Method: This was an observational and cross-sectional analysis at Kariadi General Hospital Semarang involving patients who underwent kidney transplantation from January 2016 to December 2019. The total ischemic time was recorded intraoperatively. The Body Mass Index data were provided by medical records. The program used to statistically analyze the data was SPSS 23.0, and Spearman was used for hypothesis testing. Result: This study included 25 kidney transplant recipients. The mean total ischemic time was 43,27 ± 6,63 minutes. There was a significant positive correlation between prolonged ischemic time and body mass index (r= 0,506 ; p= 0,010). Conclusion: Prolonged total ischemic time was positively correlated with increased body mass index and these results are statistically significant.

scholarly journals Obesity and shift work: chronobiological aspects

2010 ◽  
Vol 23 (1) ◽  
pp. 155-168 ◽  
Author(s):  
L. C. Antunes ◽  
R. Levandovski ◽  
G. Dantas ◽  
W. Caumo ◽  
M. P. Hidalgo
Keyword(s):  
Shift Work ◽  
Biological Clock ◽  
Overweight And Obesity ◽  
Present Review ◽  
Epidemiological Evidence ◽  
Shift Workers ◽  
Circadian Misalignment ◽  
Increased Risk ◽  
Business Competitiveness ◽  
The Impact

The present review has the objective of summarising chronobiological aspects of shift work and obesity. There was a systematic search in PubMed databases, using the following descriptors: shift work; obesity; biological clock. Shift work is extremely frequent in several services and industries, in order to systematise the needs for flexibility of the workforce, necessary to optimise productivity and business competitiveness. In developing countries, this population represents a considerable contingent workforce. Recently, studies showed that overweight and obesity are more prevalent in shift workers than day workers. In addition, the literature shows that shift workers seem to gain weight more often than those workers submitted to a usual work day. In conclusion, there is considerable epidemiological evidence that shift work is associated with increased risk for obesity, diabetes and CVD, perhaps as a result of physiological maladaptation to chronically sleeping and eating at abnormal circadian times. The impact of shift work on metabolism supports a possible pathway to the development of obesity and its co-morbities. The present review demonstrated the adverse cardiometabolic implications of circadian misalignment, as occurs chronically with shift workers.

scholarly journals Alcohol Use and the Risk of Communicable Diseases

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3317
Author(s):  
Neo K. Morojele ◽  
Sheela V. Shenoi ◽  
Paul A. Shuper ◽  
Ronald Scott Braithwaite ◽  
Jürgen Rehm
Keyword(s):  
Alcohol Use ◽  
Treatment Outcomes ◽  
Respiratory Infections ◽  
Communicable Diseases ◽  
The Body ◽  
Health Concern ◽  
Severe Illness ◽  
Individual Level ◽  
Life Years ◽  
Increased Risk

The body of knowledge on alcohol use and communicable diseases has been growing in recent years. Using a narrative review approach, this paper discusses alcohol’s role in the acquisition of and treatment outcomes from four different communicable diseases: these include three conditions included in comparative risk assessments to date—Human Immunodeficiency Virus (HIV)/AIDS, tuberculosis (TB), and lower respiratory infections/pneumonia—as well as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) because of its recent and rapid ascension as a global health concern. Alcohol-attributable TB, HIV, and pneumonia combined were responsible for approximately 360,000 deaths and 13 million disability-adjusted life years lost (DALYs) in 2016, with alcohol-attributable TB deaths and DALYs predominating. There is strong evidence that alcohol is associated with increased incidence of and poorer treatment outcomes from HIV, TB, and pneumonia, via both behavioral and biological mechanisms. Preliminary studies suggest that heavy drinkers and those with alcohol use disorders are at increased risk of COVID-19 infection and severe illness. Aside from HIV research, limited research exists that can guide interventions for addressing alcohol-attributable TB and pneumonia or COVID-19. Implementation of effective individual-level interventions and alcohol control policies as a means of reducing the burden of communicable diseases is recommended.

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