Acylated and Unacylated Ghrelin Promote Proliferation and Inhibit Apoptosis of Pancreatic β-Cells and Human Islets: Involvement of 3′,5′-Cyclic Adenosine Monophosphate/Protein Kinase A, Extracellular Signal-Regulated Kinase 1/2, and Phosphatidyl Inositol 3-Kinase/Akt Signaling

Riccarda Granata; Fabio Settanni; Luigi Biancone; Letizia Trovato; Rita Nano; Federico Bertuzzi; Silvia Destefanis; Marta Annunziata; Monica Martinetti; Filomena Catapano; Corrado Ghè; Jorgen Isgaard; Mauro Papotti; Ezio Ghigo; Giampiero Muccioli

doi:10.1210/en.2006-0266

Acylated and Unacylated Ghrelin Promote Proliferation and Inhibit Apoptosis of Pancreatic β-Cells and Human Islets: Involvement of 3′,5′-Cyclic Adenosine Monophosphate/Protein Kinase A, Extracellular Signal-Regulated Kinase 1/2, and Phosphatidyl Inositol 3-Kinase/Akt Signaling

Endocrinology ◽

10.1210/en.2006-0266 ◽

2007 ◽

Vol 148 (2) ◽

pp. 512-529 ◽

Cited By ~ 201

Author(s):

Riccarda Granata ◽

Fabio Settanni ◽

Luigi Biancone ◽

Letizia Trovato ◽

Rita Nano ◽

...

Keyword(s):

Phosphatidyl Inositol ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Human Islets ◽

Akt Signaling ◽

Β Cells ◽

Pancreatic Β Cells ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Kinase A

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Glucagon-Like Peptide-1 Causes Pancreatic Duodenal Homeobox-1 Protein Translocation from the Cytoplasm to the Nucleus of Pancreatic β-Cells by a Cyclic Adenosine Monophosphate/Protein Kinase A-Dependent Mechanism

Endocrinology ◽

10.1210/endo.142.5.8128 ◽

2001 ◽

Vol 142 (5) ◽

pp. 1820-1827 ◽

Cited By ~ 52

Author(s):

Xiaolin Wang ◽

Jie Zhou ◽

Máire E. Doyle ◽

Josephine M. Egan

Keyword(s):

Protein Kinase ◽

Protein Translocation ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Β Cells ◽

Pancreatic Β Cells ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1 ◽

Kinase A ◽

Dependent Mechanism

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Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

Molecular and Cellular Endocrinology ◽

10.1016/j.mce.2013.04.027 ◽

2013 ◽

Vol 375 (1-2) ◽

pp. 89-96 ◽

Cited By ~ 50

Author(s):

Yongneng Zhang ◽

Tetsuya Yamamoto ◽

Ichiro Hisatome ◽

Youfeng Li ◽

Weijie Cheng ◽

...

Keyword(s):

Oxidative Stress ◽

Uric Acid ◽

Protein Kinase ◽

Growth Inhibition ◽

Adenosine Monophosphate ◽

Signal Pathways ◽

Β Cells ◽

Pancreatic Β Cells ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal

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GW24-e1177 Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

Heart ◽

10.1136/heartjnl-2013-304613.226 ◽

2013 ◽

Vol 99 (Suppl 3) ◽

pp. A83.2-A83

Author(s):

Zhang Yongneng ◽

Tetsuya Yamamoto ◽

Yichiro Hisatome ◽

Li Youfeng ◽

Cheng Weijie ◽

...

Keyword(s):

Oxidative Stress ◽

Uric Acid ◽

Protein Kinase ◽

Growth Inhibition ◽

Adenosine Monophosphate ◽

Signal Pathways ◽

Β Cells ◽

Pancreatic Β Cells ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal

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Amelioration of Diabetes in a Murine Model upon Transplantation of Pancreatic β-Cells with Optogenetic Control of Cyclic Adenosine Monophosphate

ACS Synthetic Biology ◽

10.1021/acssynbio.9b00262 ◽

2019 ◽

Vol 8 (10) ◽

pp. 2248-2255

Author(s):

Fan Zhang ◽

Emmanuel S. Tzanakakis

Keyword(s):

Murine Model ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Β Cells ◽

Pancreatic Β Cells ◽

Optogenetic Control

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Effects of Dexmedetomidine on Rats with Functional Chronic Visceral Pain Based on Protein Expressions in the Extracellular Signal-Regulated Kinase 1/Cyclic Adenosine Monophosphate Response Element-Binding Protein Signaling Pathway

10.36468/pharmaceutical-sciences.811 ◽

2021 ◽

Vol 83 (3) ◽

Author(s):

J. Li ◽

Huizhong Tang ◽

Li Ma

Keyword(s):

Signaling Pathway ◽

Visceral Pain ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Protein Signaling ◽

Response Element ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Protein Expressions ◽

Element Binding Protein

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Activation of Exchange Protein Directly Activated by Cyclic Adenosine Monophosphate and Protein Kinase A Regulate Common and Distinct Steps in Promoting Plasma Membrane Exocytic and Granule-to-Granule Fusions in Rat Islet β Cells

Pancreas ◽

10.1097/mpa.0b013e318073d1c9 ◽

2007 ◽

Vol 35 (3) ◽

pp. e45-e54 ◽

Cited By ~ 19

Author(s):

Edwin P. Kwan ◽

Xiaodong Gao ◽

Yuk M. Leung ◽

Herbert Y. Gaisano

Keyword(s):

Plasma Membrane ◽

Protein Kinase ◽

Protein Kinase A ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Β Cells ◽

Kinase A ◽

Exchange Protein

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Stevioside acts directly on pancreatic β cells to secrete insulin: Actions independent of cyclic adenosine monophosphate and adenosine triphosphate—sensitivie K+-channel activity

Metabolism ◽

10.1016/s0026-0495(00)91325-8 ◽

2000 ◽

Vol 49 (2) ◽

pp. 208-214 ◽

Cited By ~ 147

Author(s):

P.B. Jeppesen ◽

S. Gregersen ◽

C.R. Poulsen ◽

K. Hermansen

Keyword(s):

Adenosine Triphosphate ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

K Channel ◽

Channel Activity ◽

Β Cells ◽

Pancreatic Β Cells

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Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats via Extracellular Signal-Regulated Kinase/Cyclic Adenosine Monophosphate Response Element Binding Protein Signaling Pathway

World Neurosurgery ◽

10.1016/j.wneu.2019.03.232 ◽

2019 ◽

Vol 127 ◽

pp. e624-e630 ◽

Cited By ~ 1

Author(s):

Lu Teng ◽

Weiguang Chen ◽

Changyou Yin ◽

Hongtao Zhang ◽

Qingping Zhao

Keyword(s):

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Protein Signaling ◽

Extracellular Signal Regulated Kinase ◽

Cerebral Ischemia Reperfusion ◽

Extracellular Signal ◽

Element Binding Protein ◽

Cerebral Ischemia Reperfusion Injury

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Investigation of Extracellular Signal-Regulated Kinase 2 Mitogen-Activated Protein Kinase Phosphorylation and Regulation of Activity of PDE4 Cyclic Adenosine Monophosphate-Specific Phosphodiesterases

Phosphodiesterase Methods and Protocols ◽

10.1385/1-59259-839-0:225 ◽

2005 ◽

pp. 225-238 ◽

Cited By ~ 3

Author(s):

Elaine V. Hill ◽

Miles D. Houslay ◽

George S. Baillie

Keyword(s):

Protein Kinase ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Mitogen Activated Protein Kinase ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Regulation Of Activity ◽

Kinase Phosphorylation

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Cyclic Adenosine Monophosphate–Independent Tyrosine Phosphorylation of NR2B Mediates Cocaine-Induced Extracellular Signal-Regulated Kinase Activation

Biological Psychiatry ◽

10.1016/j.biopsych.2010.08.031 ◽

2011 ◽

Vol 69 (3) ◽

pp. 218-227 ◽

Cited By ~ 70

Author(s):

Vincent Pascoli ◽

Antoine Besnard ◽

Denis Hervé ◽

Christiane Pagès ◽

Nicolas Heck ◽

...

Keyword(s):

Tyrosine Phosphorylation ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Kinase Activation ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal

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