Leptin Inhibits Apoptosis in Thymus through a Janus Kinase-2-Independent, Insulin Receptor Substrate-1/Phosphatidylinositol-3 Kinase-Dependent Pathway

Eli Mansour; Fernanda G. Pereira; Eliana P. Araújo; Maria E. C. Amaral; Joseane Morari; Natasha R. Ferraroni; Diogenes S. Ferreira; Irene Lorand-Metze; Lício A. Velloso

doi:10.1210/en.2006-0223

Leptin Inhibits Apoptosis in Thymus through a Janus Kinase-2-Independent, Insulin Receptor Substrate-1/Phosphatidylinositol-3 Kinase-Dependent Pathway

Endocrinology ◽

10.1210/en.2006-0223 ◽

2006 ◽

Vol 147 (11) ◽

pp. 5470-5479 ◽

Cited By ~ 34

Author(s):

Eli Mansour ◽

Fernanda G. Pereira ◽

Eliana P. Araújo ◽

Maria E. C. Amaral ◽

Joseane Morari ◽

...

Keyword(s):

Insulin Receptor ◽

Janus Kinase ◽

Insulin Receptor Substrate ◽

Janus Kinase 2 ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Dependent Pathway ◽

Phosphatidylinositol 3

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Persistent Activation of Phosphatidylinositol 3-Kinase Causes Insulin Resistance Due to Accelerated Insulin-Induced Insulin Receptor Substrate-1 Degradation in 3T3-L1 Adipocytes*

Endocrinology ◽

10.1210/endo.141.6.7516 ◽

2000 ◽

Vol 141 (6) ◽

pp. 1930-1935 ◽

Cited By ~ 27

Author(s):

Katsuya Egawa ◽

Naoki Nakashima ◽

Prem M. Sharma ◽

Hiroshi Maegawa ◽

Yoshio Nagai ◽

...

Keyword(s):

Insulin Resistance ◽

Insulin Receptor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Platelet-derived Growth Factor Inhibits Insulin Stimulation of Insulin Receptor Substrate-1-associated Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes without Affecting Glucose Transport

Journal of Biological Chemistry ◽

10.1074/jbc.273.39.25139 ◽

1998 ◽

Vol 273 (39) ◽

pp. 25139-25147 ◽

Cited By ~ 67

Author(s):

Patricia A. Staubs ◽

James G. Nelson ◽

Donna R. Reichart ◽

Jerrold M. Olefsky

Keyword(s):

Growth Factor ◽

Insulin Receptor ◽

Glucose Transport ◽

Platelet Derived Growth Factor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Stimulation ◽

Insulin Receptor Substrate 1 ◽

Stimulation Of ◽

Phosphatidylinositol 3

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Insulin-induced egr-1 and c-fos expression in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and phosphatidylinositol 3-kinase activation.

Journal of Biological Chemistry ◽

10.1074/s0021-9258(19)67421-1 ◽

2001 ◽

Vol 272 (5) ◽

pp. 3124

Author(s):

Shuko Harada ◽

Robert M. Smith ◽

Judith A. Smith ◽

Morris F. White ◽

Leonard Jarett

Keyword(s):

Protein Kinase ◽

Insulin Receptor ◽

Mitogen Activated Protein Kinase ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Kinase Activation ◽

Mitogen Activated Protein ◽

Fos Expression ◽

Phosphatidylinositol 3

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Up-regulation of Endothelial Nitric-oxide Synthase Promoter by the Phosphatidylinositol 3-Kinase γ/Janus Kinase 2/MEK-1-dependent Pathway

Journal of Biological Chemistry ◽

10.1074/jbc.m005305200 ◽

2000 ◽

Vol 276 (2) ◽

pp. 1211-1219 ◽

Cited By ~ 51

Author(s):

Katarzyna Cieslik ◽

Charles S. Abrams ◽

Kenneth K. Wu

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Janus Kinase ◽

Janus Kinase 2 ◽

Phosphatidylinositol 3 Kinase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide ◽

Dependent Pathway ◽

Phosphatidylinositol 3

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Growth Hormone Inhibition of Glucose Uptake in Adipocytes Occurs without Affecting GLUT4 Translocation through an Insulin Receptor Substrate-2-Phosphatidylinositol 3-Kinase-dependent Pathway

Journal of Biological Chemistry ◽

10.1074/jbc.m808282200 ◽

2009 ◽

Vol 284 (10) ◽

pp. 6061-6070 ◽

Cited By ~ 19

Author(s):

Naoko Sasaki-Suzuki ◽

Kiyoshi Arai ◽

Tomomi Ogata ◽

Kouhei Kasahara ◽

Hideyuki Sakoda ◽

...

Keyword(s):

Growth Hormone ◽

Insulin Receptor ◽

Glucose Uptake ◽

Insulin Receptor Substrate ◽

Glut4 Translocation ◽

Phosphatidylinositol 3 Kinase ◽

Dependent Pathway ◽

Phosphatidylinositol 3

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Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1

Molecular Endocrinology ◽

10.1210/me.9.4.435 ◽

1995 ◽

Vol 9 (4) ◽

pp. 435-442 ◽

Cited By ~ 6

Author(s):

V. Sanchez-Margalet

Keyword(s):

Insulin Receptor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Adaptor Molecule ◽

Phosphatidylinositol 3

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Insulin-stimulated cell growth in insulin receptor substrate-1–deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3-kinase–independent pathway

Journal of Cellular Biochemistry ◽

10.1002/(sici)1097-4644(19980801)70:2<268::aid-jcb12>3.0.co;2-j ◽

1998 ◽

Vol 70 (2) ◽

pp. 268-280 ◽

Cited By ~ 20

Author(s):

Biancamaria Gliozzo ◽

Chin K. Sung ◽

PierLuigi Scalia ◽

Vincenzo Papa ◽

Francesco Frasca ◽

...

Keyword(s):

Cell Growth ◽

Insulin Receptor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Gastrin Stimulates Tyrosine Phosphorylation of Insulin Receptor Substrate 1 and Its Association with Grb2 and the Phosphatidylinositol 3-Kinase

Journal of Biological Chemistry ◽

10.1074/jbc.271.42.26356 ◽

1996 ◽

Vol 271 (42) ◽

pp. 26356-26361 ◽

Cited By ~ 60

Author(s):

Aline Kowalski-Chauvel ◽

Lucien Pradayrol ◽

Nicole Vaysse ◽

Catherine Seva

Keyword(s):

Insulin Receptor ◽

Tyrosine Phosphorylation ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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SH3 domain of the phosphatidylinositol 3-kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2007.10.187 ◽

2008 ◽

Vol 365 (3) ◽

pp. 433-438 ◽

Cited By ~ 2

Author(s):

Yuichi Ikegami ◽

Kouichi Inukai ◽

Takuya Awata ◽

Tomoichiro Asano ◽

Shigehiro Katayama

Keyword(s):

Insulin Receptor ◽

Sh3 Domain ◽

Regulatory Subunit ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone

Molecular Endocrinology ◽

10.1210/me.8.5.545 ◽

1994 ◽

Vol 8 (5) ◽

pp. 545-557 ◽

Cited By ~ 19

Author(s):

M. J. Saad

Keyword(s):

Insulin Receptor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

Download Full-text