scholarly journals Growth Hormone Inhibition of Glucose Uptake in Adipocytes Occurs without Affecting GLUT4 Translocation through an Insulin Receptor Substrate-2-Phosphatidylinositol 3-Kinase-dependent Pathway

2009 ◽  
Vol 284 (10) ◽  
pp. 6061-6070 ◽  
Author(s):  
Naoko Sasaki-Suzuki ◽  
Kiyoshi Arai ◽  
Tomomi Ogata ◽  
Kouhei Kasahara ◽  
Hideyuki Sakoda ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Receptor ◽  
Glucose Uptake ◽  
Insulin Receptor Substrate ◽  
Glut4 Translocation ◽  
Phosphatidylinositol 3 Kinase ◽  
Dependent Pathway ◽  
Phosphatidylinositol 3

scholarly journals IL-10 Inhibits Apoptosis of Promyeloid Cells by Activating Insulin Receptor Substrate-2 and Phosphatidylinositol 3′-Kinase

2001 ◽  
Vol 167 (8) ◽  
pp. 4436-4442 ◽  
Author(s):  
Jian-Hua Zhou ◽  
Suzanne R. Broussard ◽  
Klemen Strle ◽  
Gregory G. Freund ◽  
Rodney W. Johnson ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Insulin Receptor Substrate ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

Phosphatidylinositol 3-Kinase and Prostaglandylinositol Cyclic Phosphate (Cyclic PIP), a Mediator of Insulin Action, in the Signal Transduction of Insulin

2000 ◽  
Vol 381 (11) ◽  
pp. 1139-1141 ◽  
Author(s):  
A. Gypakis ◽  
H.K. Wasner
Keyword(s):  
Insulin Receptor ◽  
Glucose Transport ◽  
Functional Role ◽  
Specific Inhibitor ◽  
Insulin Receptor Substrate ◽  
Phosphatidylinositol 3 Kinase ◽  
Downstream Signaling ◽  
Cyclic Phosphate ◽  
Phosphatidylinositol 3

Abstract It has been suggested that downstream signaling from the insulin receptor to the level of the protein kinases and protein phosphatases is accomplished by prostaglandylinositol cyclic phosphate (cyclic PIP), a proposed second messenger of insulin. However, evidence points also to both phosphatidylinositol 3-kinase, which binds to the tyrosine phosphorylated insulin receptor substrate-1, and the Ras complex in insulin's downstream signaling. We have examined whether a correlation exists between these various observations. It was found that wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase, prevented insulin-induced, as well as cyclic PIP-induced activation of glucose transport, indicating that PI 3-kinase action on glucose transport involves downstream signaling of both insulin and cyclic PIP. Wortmannin has no effect on cyclic PIP synthase activity nor on the substrate production for cyclic PIP synthesis either, indicating that the functional role of PI 3-kinase is exclusively downstream of cyclic PIP.

scholarly journals Essential Role of Insulin Receptor Substrate-2 in Insulin Stimulation of Glut4 Translocation and Glucose Uptake in Brown Adipocytes

2000 ◽  
Vol 275 (33) ◽  
pp. 25494-25501 ◽  
Author(s):  
Mathias Fasshauer ◽  
Johannes Klein ◽  
Kohjiro Ueki ◽  
Kristina M. Kriauciunas ◽  
Manuel Benito ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Glucose Uptake ◽  
Essential Role ◽  
Insulin Receptor Substrate ◽  
Glut4 Translocation ◽  
Insulin Stimulation ◽  
Brown Adipocytes ◽  
Stimulation Of
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