scholarly journals Aquaporin-2 Is Retrieved to the Apical Storage Compartment via Early Endosomes and Phosphatidylinositol 3-Kinase-Dependent Pathway

Endocrinology ◽  
2004 ◽  
Vol 145 (9) ◽  
pp. 4375-4383 ◽  
Author(s):  
Yuki Tajika ◽  
Toshiyuki Matsuzaki ◽  
Takeshi Suzuki ◽  
Takeo Aoki ◽  
Haruo Hagiwara ◽  
...  
Keyword(s):  
Phosphatidylinositol 3 Kinase ◽  
Storage Compartment ◽  
Aquaporin 2 ◽  
Early Endosomes ◽  
Dependent Pathway ◽  
Phosphatidylinositol 3

scholarly journals Rabenosyn-5, a Novel Rab5 Effector, Is Complexed with Hvps45 and Recruited to Endosomes through a Fyve Finger Domain

2000 ◽  
Vol 151 (3) ◽  
pp. 601-612 ◽  
Author(s):  
Erik Nielsen ◽  
Savvas Christoforidis ◽  
Sandrine Uttenweiler-Joseph ◽  
Marta Miaczynska ◽  
Frederique Dewitte ◽  
...  
Keyword(s):  
Early Endosome ◽  
Effector Proteins ◽  
Endosomal Trafficking ◽  
Membrane Domains ◽  
Phosphatidylinositol 3 Kinase ◽  
Early Endosomes ◽  
Site Of Action ◽  
Endosomal Membranes ◽  
Novel Protein ◽  
Phosphatidylinositol 3

Rab5 regulates endocytic membrane traffic by specifically recruiting cytosolic effector proteins to their site of action on early endosomal membranes. We have characterized a new Rab5 effector complex involved in endosomal fusion events. This complex includes a novel protein, Rabenosyn-5, which, like the previously characterized Rab5 effector early endosome antigen 1 (EEA1), contains an FYVE finger domain and is recruited in a phosphatidylinositol-3-kinase–dependent fashion to early endosomes. Rabenosyn-5 is complexed to the Sec1-like protein hVPS45. hVPS45 does not interact directly with Rab5, therefore Rabenosyn-5 serves as a molecular link between hVPS45 and the Rab5 GTPase. This property suggests that Rabenosyn-5 is a closer mammalian functional homologue of yeast Vac1p than EEA1. Furthermore, although both EEA1 and Rabenosyn-5 are required for early endosomal fusion, only overexpression of Rabenosyn-5 inhibits cathepsin D processing, suggesting that the two proteins play distinct roles in endosomal trafficking. We propose that Rab5-dependent formation of membrane domains enriched in phosphatidylinositol-3-phosphate has evolved as a mechanism for the recruitment of multiple effector proteins to mammalian early endosomes, and that these domains are multifunctional, depending on the differing activities of the effector proteins recruited.

scholarly journals Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats

2016 ◽  
Vol 36 (2) ◽  
Author(s):  
Tsung-Ming Lee ◽  
Wei-Ting Chen ◽  
Nen-Chung Chang
Keyword(s):  
Myocardial Infarction ◽  
Ventricular Arrhythmias ◽  
Sympathetic Innervation ◽  
Dipeptidyl Peptidase ◽  
Phosphatidylinositol 3 Kinase ◽  
Dipeptidyl Peptidase 4 ◽  
Dipeptidyl Peptidase 4 Inhibitor ◽  
Dependent Pathway ◽  
Phosphatidylinositol 3

The rats after myocardial infarction (MI) exposed to sitagliptin, a dipeptidyl peptidase-4 inhibitor, led to attenuated sympathetic innervation probably through a phosphatidylinositol 3-kinase and Akt-dependent pathway.

scholarly journals A Phosphatidylinositol 3-Kinase-dependent Pathway That Differentially Regulates c-Raf and A-Raf

1999 ◽  
Vol 274 (11) ◽  
pp. 7002-7010 ◽  
Author(s):  
Shari L. Sutor ◽  
Benjamin T. Vroman ◽  
Eric A. Armstrong ◽  
Robert T. Abraham ◽  
Larry M. Karnitz
Keyword(s):  
Phosphatidylinositol 3 Kinase ◽  
Dependent Pathway ◽  
Phosphatidylinositol 3

scholarly journals Adrenomedullin Induces Endothelium-Dependent Vasorelaxation via the Phosphatidylinositol 3-Kinase/Akt–Dependent Pathway in Rat Aorta

2001 ◽  
Vol 89 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Hiroaki Nishimatsu ◽  
Etsu Suzuki ◽  
Daisuke Nagata ◽  
Nobuo Moriyama ◽  
Hiroshi Satonaka ◽  
...  
Keyword(s):  
Rat Aorta ◽  
Phosphatidylinositol 3 Kinase ◽  
Dependent Pathway ◽  
Phosphatidylinositol 3

scholarly journals Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1998 ◽  
Vol 273 (45) ◽  
pp. 29864-29872 ◽  
Author(s):  
Robin C. Muise-Helmericks ◽  
H. Leighton Grimes ◽  
Alfonso Bellacosa ◽  
Scott E. Malstrom ◽  
Philip N. Tsichlis ◽  
...  
Keyword(s):  
Cyclin D ◽  
Phosphatidylinositol 3 Kinase ◽  
Dependent Pathway ◽  
Phosphatidylinositol 3
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