scholarly journals De NovoTestosterone Production in Luteinizing Hormone Receptor Knockout Mice after Transplantation of Leydig Stem Cells

Endocrinology ◽  
2004 ◽  
Vol 145 (9) ◽  
pp. 4011-4015 ◽  
Author(s):  
Kirk C. Lo ◽  
Zhenmin Lei ◽  
Ch. Venkateswara Rao ◽  
Josie Beck ◽  
Dolores J. Lamb
Keyword(s):  
Stem Cells ◽  
Luteinizing Hormone ◽  
Knockout Mice ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor

Identification of Gubernacular Androgen Responsive Genes in Luteinizing Hormone Receptor Knockout Mice.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 564-564
Author(s):  
Yong Siow ◽  
Shengqiang Li ◽  
Jing Lin ◽  
Xian Li ◽  
Zi-Jian Lan ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Knockout Mice ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor

Luteinizing hormone receptor

2007 ◽  
Author(s):  
Thomas Buech ◽  
Pascal Nurwakagari ◽  
David Ben-Menahem ◽  
Thomas Gudermann
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor

scholarly journals Possible Relevance of Soluble Luteinizing Hormone Receptor during Development and Adulthood in Boys and Men

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1329
Author(s):  
Li Juel Mortensen ◽  
Mette Lorenzen ◽  
Anne Jørgensen ◽  
Jakob Albrethsen ◽  
Niels Jørgensen ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Adrenal Glands ◽  
Seminal Fluid ◽  
Body Fluids ◽  
Luteinizing Hormone Receptor ◽  
Gonadal Function ◽  
Fetal Kidney ◽  
Healthy Men ◽  
Human Fetal Kidney

Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are agonists for the luteinizing hormone receptor (LHCGR) which regulates male reproductive function. LHCGR may be released into body fluids. We wish to determine whether soluble LHCGR is a marker for gonadal function. Cross-sectional, longitudinal, and intervention studies on 195 healthy boys and men and 396 men with infertility, anorchia, or Klinefelter Syndrome (KS) were used to correlate LHCGR measured in serum, seminal fluid, urine, and hepatic/renal artery and vein with gonadal function. LHCGR was determined in fluids from in vitro and in vivo models of human testicular tissue and cell lines, xenograft mouse models, and human fetal kidney and adrenal glands. Western blot showed LHCGR fragments in serum and gonadal tissue of similar size using three different antibodies. The LHCGR-ELISA had no species cross-reactivity or unspecific reaction in mouse serum even after human xenografting. Instead, sLHCGR was released into the media after the culture of a human fetal kidney and adrenal glands. Serum sLHCGR decreased markedly during puberty in healthy boys (p = 0.0001). In healthy men, serum sLHCGR was inversely associated with the Inhibin B/FSH ratio (β −0.004, p = 0.027). In infertile men, seminal fluid sLHCGR was inversely associated with serum FSH (β 0.006, p = 0.009), sperm concentration (β −3.5, p = 0.003) and total sperm count (β −3.2, p = 0.007). The injection of hCG lowered sLHCGR in serum and urine of healthy men (p < 0.01). In conclusion, sLHCGR is released into body-fluids and linked with pubertal development and gonadal function. Circulating sLHCGR in anorchid men suggests that sLHCGR in serum may originate from and possibly exert actions in non-gonadal tissues. (ClinicalTrials: NTC01411527, NCT01304927, NCT03418896).

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