scholarly journals Molecular Characterization of Postnatal Development of Testicular Steroidogenesis in Luteinizing Hormone Receptor Knockout Mice

Endocrinology ◽  
2004 ◽  
Vol 145 (3) ◽  
pp. 1453-1463 ◽  
Author(s):  
Fu-ping Zhang ◽  
Tomi Pakarainen ◽  
Fei Zhu ◽  
Matti Poutanen ◽  
Ilpo Huhtaniemi
Keyword(s):  
Luteinizing Hormone ◽  
Postnatal Development ◽  
Molecular Characterization ◽  
Knockout Mice ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Testicular Steroidogenesis

Monoclonal Antibodies against Luteinizing Hormone Receptor. Immunochemical Characterization of the Receptor*

Endocrinology ◽  
1990 ◽  
Vol 127 (5) ◽  
pp. 2090-2098 ◽  
Author(s):  
MAI THU VUHAI-LUUTHI ◽  
ANDRÉ JOLIVET ◽  
BAHIJA JALLAL ◽  
ROLAND SALESSE ◽  
JEAN-MICHEL BIDART ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Immunochemical Characterization

Characterization of the Primate Luteinizing Hormone Receptor in Testis Homogenates and Leydig Cells

1979 ◽  
Vol 48 (4) ◽  
pp. 680-685 ◽  
Author(s):  
TERRY F. DAVIES ◽  
PATRICK C. WALSH ◽  
GARY D. HODGEN ◽  
MARIA L. DUFAU ◽  
KEVIN J. CATT
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Leydig Cells ◽  
Luteinizing Hormone Receptor

scholarly journals Characterization of constitutive activation and inactivation mutants in conserved regions of the eel luteinizing hormone receptor

2019 ◽  
Author(s):  
Munkhzaya Byambaragchaa ◽  
Dong-An Kim ◽  
Dae-Jung Kim ◽  
Sun-Mee Hong ◽  
Myung-Hwa Kang ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Fold Increase ◽  
Luteinizing Hormone Receptor ◽  
Maximal Response ◽  
Dependent Manner ◽  
Time Resolved ◽  
Inactivating Mutations

Abstract Background: We analyzed signal transduction of three constitutively activating mutants (designated M410T, L469R, and D590Y) and two inactivating mutants (D383N and Y546F) of the eel luteinizing hormone receptor (LHR), known to be naturally occurring in humans as LHR. The objective of the present study is to assess the functional effects of these mutations in signal transduction. Methods: Site-directed mutant receptors were transiently expressed in CHO-K1 cells and cAMP accumulation, stimulated by recombinant eelLH (rec-eelLH), was measured by homogeneous time-resolved fluorescence (HTRF) assays. Results: The cAMP response in cells expressing the wild-type eel LHR (eLHR-WT) increased in a dose-dependent manner with rec-eelLH ligand stimulation. Cells expressing the activating eelLHR mutants, M410T, L469R, and D590Y, exhibited a 4.0-, 19.1-, and 7.8-fold increase in the basal cAMP response, respectively. However, their maximal responses to agonist were approximately 73, 53, and 92%, respectively, of the maximal response of the LHR-WT. The L469R mutant exhibited a particularly marked increase in cAMP concentration in the absence of ligand. The inactivating mutations did not completely impair signal transduction. The maximal responses of the inactivating mutants, D383N and Y546F, were 32% and 24% of the LHR-WT, respectively. Conclusion: We report here the first characterization of activating and inactivating mutations in eelLHR. These results provide important data on the signal transduction of constitutively active and inactive eelLHR mutants. Keywords: eel LHR, constitutively activating/inactivating mutation

scholarly journals Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty

1995 ◽  
Vol 4 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Shinji Kosugi ◽  
Cornelis Van Dop ◽  
Mitchell E. Geffner ◽  
Wolfgang Rabl ◽  
Jean-Claude Carel ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Precocious Puberty ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Constitutive Activation

Identification of Gubernacular Androgen Responsive Genes in Luteinizing Hormone Receptor Knockout Mice.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 564-564
Author(s):  
Yong Siow ◽  
Shengqiang Li ◽  
Jing Lin ◽  
Xian Li ◽  
Zi-Jian Lan ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Knockout Mice ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor
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