scholarly journals Differential Modulation of Energy Balance by Leptin, Ciliary Neurotrophic Factor, and Leukemia Inhibitory Factor Gene Delivery: Microarray Deoxyribonucleic Acid-Chip Analysis of Gene Expression

Endocrinology ◽  
2004 ◽  
Vol 145 (4) ◽  
pp. 2035-2045 ◽  
Author(s):  
V. Prima ◽  
M. Tennant ◽  
O. S. Gorbatyuk ◽  
N. Muzyczka ◽  
P. J. Scarpace ◽  
...  
Keyword(s):  
Gene Expression ◽  
Energy Balance ◽  
Gene Delivery ◽  
Neurotrophic Factor ◽  
Leukemia Inhibitory Factor ◽  
Deoxyribonucleic Acid ◽  
Ciliary Neurotrophic Factor ◽  
Differential Modulation ◽  
Factor Gene ◽  
Chip Analysis

scholarly journals Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells

2006 ◽  
Vol 103 (20) ◽  
pp. 7871-7876 ◽  
Author(s):  
Y. Ito ◽  
S. Wiese ◽  
N. Funk ◽  
A. Chittka ◽  
W. Rossoll ◽  
...  
Keyword(s):  
Gene Expression ◽  
Schwann Cells ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Factor Gene

Ciliary neurotrophic factor-induced gene expression in human neuroblastoma cell lines

1995 ◽  
Vol 20 (6) ◽  
pp. 675-680 ◽  
Author(s):  
P. Rossino ◽  
G. Volpe ◽  
A. Negro ◽  
L. Callegaro ◽  
F. Altruda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Neurotrophic Factor ◽  
Neuroblastoma Cell ◽  
Ciliary Neurotrophic Factor ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Neuroblastoma Cell Lines

The anorexigenic cytokine ciliary neurotrophic factor stimulates POMC gene expression via receptors localized in the nucleus of arcuate neurons

2012 ◽  
Vol 302 (4) ◽  
pp. E458-E467 ◽  
Author(s):  
Odile Couvreur ◽  
Alain Aubourg ◽  
Delphine Crépin ◽  
Jéril Degrouard ◽  
Arieh Gertler ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Nucleus ◽  
Neurotrophic Factor ◽  
Energy Homeostasis ◽  
Ciliary Neurotrophic Factor ◽  
Hypothalamic Region ◽  
Diet Induced Obesity ◽  
Food Intake Regulation ◽  
Pomc Gene ◽  
Intake Regulation

Ciliary neurotrophic factor (CNTF) is a neural cytokine that reduces appetite and body weight when administrated to rodents or humans. We have demonstrated recently that the level of CNTF in the arcuate nucleus (ARC), a key hypothalamic region involved in food intake regulation, is positively correlated with protection against diet-induced obesity. However, the comprehension of the physiological significance of neural CNTF action was still incomplete because CNTF lacks a signal peptide and thus may not be secreted by the classical exocytosis pathways. Knowing that CNTF distribution shares similarities with that of its receptor subunits in the rat ARC, we hypothesized that CNTF could exert a direct intracrine effect in ARC cells. Here, we demonstrate that CNTF, together with its receptor subunits, translocates to the cell nucleus of anorexigenic POMC neurons in the rat ARC. Furthermore, the stimulation of hypothalamic nuclear fractions with CNTF induces the phosphorylation of several signaling proteins, including Akt, as well as the transcription of the POMC gene. These data strongly suggest that intracellular CNTF may directly modulate POMC gene expression via the activation of receptors localized in the cell nucleus, providing a novel plausible mechanism of CNTF action in regulating energy homeostasis.

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