Ciliary neurotrophic factor-induced gene expression in human neuroblastoma cell lines

1995 ◽  
Vol 20 (6) ◽  
pp. 675-680 ◽  
Author(s):  
P. Rossino ◽  
G. Volpe ◽  
A. Negro ◽  
L. Callegaro ◽  
F. Altruda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Neurotrophic Factor ◽  
Neuroblastoma Cell ◽  
Ciliary Neurotrophic Factor ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Neuroblastoma Cell Lines

scholarly journals Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Emilia Lekholm ◽  
Mikaela M. Ceder ◽  
Erica C. Forsberg ◽  
Helgi B. Schiöth ◽  
Robert Fredriksson
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Neurological Diseases ◽  
Expression Patterns ◽  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Knock Out ◽  
And Function ◽  
Neuroblastoma Cell Lines

Abstract Background The synaptic vesicle glycoprotein 2 (SV2) family is essential to the synaptic machinery involved in neurotransmission and vesicle recycling. The isoforms SV2A, SV2B and SV2C are implicated in neurological diseases such as epilepsy, Alzheimer’s and Parkinson’s disease. Suitable cell systems for studying regulation of these proteins are essential. Here we present gene expression data of SV2A, SV2B and SV2C in two human neuroblastoma cell lines after differentiation. Methods Human neuroblastoma cell lines SiMa and IMR-32 were treated for seven days with growth supplements (B-27 and N-2), all-trans-retinoic acid (ATRA) or vasoactive intestinal peptide (VIP) and gene expression levels of SV2 and neuronal targets were analyzed. Results The two cell lines reacted differently to the treatments, and only one of the three SV2 isoforms was affected at a time. SV2B and choline O-acetyltransferase (CHAT) expression was changed in concert after growth supplement treatment, decreasing in SiMa cells while increasing in IMR-32. ATRA treatment resulted in no detected changes in SV2 expression in either cell line while VIP increased both SV2C and dopamine transporter (DAT) in IMR-32 cells. Conclusion The synergistic expression patterns between SV2B and CHAT as well as between SV2C and DAT mirror the connectivity between these targets found in disease models and knock-out animals, although here no genetic alteration was made. These cell lines and differentiation treatments could possibly be used to study SV2 regulation and function.

Delta opioid receptor in human neuroblastoma cell lines

1986 ◽  
Vol 382 (2) ◽  
pp. 327-331 ◽  
Author(s):  
Günther Hochhaus ◽  
Victor C. Yu ◽  
Wolfgang Sadée
Keyword(s):  
Opioid Receptor ◽  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Delta Opioid Receptor ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Neuroblastoma Cell Lines

Betulinic acid induces apoptosis in human neuroblastoma cell lines

1997 ◽  
Vol 33 (12) ◽  
pp. 2007-2010 ◽  
Author(s):  
M.L Schmidt ◽  
K.L Kuzmanoff ◽  
L Ling-Indeck ◽  
J.M Pezzuto
Keyword(s):  
Cell Lines ◽  
Betulinic Acid ◽  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Neuroblastoma Cell Lines

Neurotransmitter-synthesizing enzymes in 14 human neuroblastoma cell lines

1981 ◽  
Vol 1 (3) ◽  
pp. 301-312 ◽  
Author(s):  
Robert A. Ross ◽  
June L. Biedler ◽  
Barbara A. Spengler ◽  
Donald J. Reis
Keyword(s):  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Neuroblastoma Cell Lines
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