scholarly journals Preparation and physicochemical characterization of dioctyl sodium sulfosuccinate (aerosol OT) microemulsion for oral drug delivery

2003 ◽  
Vol 4 (1) ◽  
Author(s):  
Hanan M. El-Laithy
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Physicochemical Characterization ◽  
Oral Drug ◽  
Aerosol Ot ◽  
Sodium Sulfosuccinate ◽  
Dioctyl Sodium Sulfosuccinate ◽  
Dioctyl Sodium

Preparation and characterization of mucus-penetrating papain/poly(acrylic acid) nanoparticles for oral drug delivery applications

2012 ◽  
Vol 15 (1) ◽  
Author(s):  
Christiane Müller ◽  
Katharina Leithner ◽  
Sabine Hauptstein ◽  
Fabian Hintzen ◽  
Willi Salvenmoser ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Acrylic Acid ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Drug Delivery Applications ◽  
Poly Acrylic Acid

scholarly journals SPRAY DRIED LACTOSE BASED PRONIOSOMES AS STABLE PROVESICULAR DRUG DELIVERY CARRIERS: SCREENING, FORMULATION, AND PHYSICOCHEMICAL CHARACTERIZATION

2018 ◽  
Vol 10 (5) ◽  
pp. 125 ◽  
Author(s):  
Ali Nasr ◽  
Mona Qushawy ◽  
Shady Swidan
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Zeta Potential ◽  
Oral Drug Delivery ◽  
Physicochemical Characterization ◽  
Water Soluble ◽  
Oral Drug ◽  
Flow Properties ◽  
Poorly Water Soluble ◽  
Spray Dried

Objective: In the present investigation efforts were considered to optimize the different conditions for the preparation of spray dried lactose based proniosomes. The aim of this research was to investigate the feasibility of proniosomes as stable precursors for the development of niosomes as oral drug delivery system for poorly water-soluble drugs.Methods: A total of twenty-eight plain proniosomal formulae were prepared with various surfactant-cholesterol loading ratios in each formula using spray dried lactose as a carrier. Span 20, 40, 60 and 80 were used in various molar ratios with cholesterol. Different evaluation techniques were performed to study the performance of the prepared proniosomes. The micromeritic properties of the prepared proniosomes were analyzed. The reconstituted niosomes were further evaluated for morphological characterization using transmission electron microscope (TEM), particle size analysis, zeta potential, and polydispersity index (PDI). Finally, selected proniosomal formulae were tested for stability study.Results: The proniosomal formulae prepared using span 40 and span 60 exhibited excellent flowability while those prepared with span 20 and span 80 showed poor flow properties. TEM photographs revealed that the vesicles were discrete, spherical without aggregation. The mean vesicle size of reconstituted niosomes was found to be in the range between (252.9±0.43–624.3±0.23 nm) with perfect PDI values (0.387±0.05–0.835±0.03). The negative values of zeta potential indicated that all prepared formulae were stabilized by electrostatic repulsion forces. Stability studies confirmed that proniosomes give a more stable system that could overcome the problems of standard niosomes. Formulae with the smallest particle size, higher surface charge values and best flow properties were selected to be loaded with poorly soluble drugs for further study.Conclusion: The obtained results offered evidence that spray-dried lactose based proniosomes are promising stable drug delivery carriers and ready to incorporate various poorly water-soluble drugs in order to improve their limited oral bioavailability.

Development and characterization of anionic liposaccharides for enhanced oral drug delivery

2012 ◽  
Vol 430 (1-2) ◽  
pp. 120-128 ◽  
Author(s):  
Adel S. Abdelrahim ◽  
Pavla Simerska ◽  
Istvan Toth
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Oral Drug

The construction and characterization of hybrid paclitaxel-in-micelle-in-liposome systems for enhanced oral drug delivery

2017 ◽  
Vol 160 ◽  
pp. 572-580 ◽  
Author(s):  
Yimu Li ◽  
Zheng Chen ◽  
Yanan Cui ◽  
Guangxi Zhai ◽  
Lingbing Li
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Oral Drug
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