Interactions of Biologically Active Redox-Sensitive Dyes with Nanomaterials: Mass Spectrometric Diagnostics

2016 ◽  
pp. 209-250
Keyword(s):  
Mass Spectrometric ◽  
Biologically Active

scholarly journals Chemical and Pharmacological Evaluation of Hulls of Prunus dulcis Nuts

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Muhammad Nasimullah Qureshi ◽  
Sodik Numonov ◽  
Haji Akber Aisa
Keyword(s):  
Ethanol Extract ◽  
Prunus Dulcis ◽  
Antimicrobial Activities ◽  
Mass Spectrometric ◽  
Biologically Active ◽  
Total Flavonoid ◽  
Spectrometric Analysis ◽  
Butanol Extract ◽  
Benzoic Acid Derivatives ◽  
Dried Extract

Researchers have shown that the almond hulls, normally wasted after utilization of nuts, contain a number of biologically active compounds based on which the present study has been carried out. Focus is placed on the mass spectrometric determination of the analytes along with the estimation of total polyphenolic and total flavonoid contents in the 70% ethanol extract. After partitioning the 70% ethanol extract in hexane, chloroform, ethyl acetate, n-butanol, and water, all the extracts were evaluated for their antioxidant, antidiabetic, and antimicrobial activities. The results delivered total polyphenolic compounds as gallic acid equivalents (1% w/w) of the dried extract and total flavonoid contents as quercetin equivalents (0.2% w/w) of the dried extract. Mass spectrometric analysis resulted in the identification of 15 compounds containing various derivatives of (epi)catechin, chlorogenic acid, kaempferol, isorhamnetin and their glycosides, ursolic acid, amygdalactone, and benzoic acid derivatives. Antioxidant activity experiments showed that highest activity was found in n-butanol extract among the studied samples with IC50 value as 76.04 μg/ml, while hexane and chloroform extracts were active against the PTP1B enzyme with IC50 values 9.66 μg/ml and 37.95 μg/ml, respectively. Hexane and chloroform fractions were active against Staphylococcus aureus with the zone of inhibition diameter 9 mm and 12 mm, respectively.

scholarly journals Ecdysteroids are present in the blood of wild passerine birds

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sándor Hornok ◽  
Attila Csorba ◽  
Dávid Kováts ◽  
Tibor Csörgő ◽  
Attila Hunyadi
Keyword(s):  
Sexual Maturation ◽  
Bird Species ◽  
Blood Stream ◽  
Mass Spectrometric ◽  
Biologically Active ◽  
Passerine Birds ◽  
High Metabolic Rate ◽  
Blood Samples ◽  
High Concentrations ◽  
Different Levels

AbstractEcdysteroids (arthropod molting hormones) play an important role in the development and sexual maturation of arthropods, and they have been shown to have anabolic and “energizing” effect in higher vertebrates. The aim of this study was to assess ecdysteroid diversity, levels according to bird species and months, as well as to observe the molting status of hard ticks (Acari: Ixodidae) infesting the birds. Therefore, blood samples and ticks were collected from 245 birds (244 songbirds and a quail). Mass spectrometric analyses showed that 15 ecdysteroids were regularly present in the blood samples. Molting hormones biologically most active in insects (including 20-hydroxyecdysone [20E], 2deoxy-20E, ajugasterone C and dacryhainansterone) reached different levels of concentration according to bird species and season. Similarly to ecdysteroids, the seasonal presence of affected, apolytic ticks peaked in July and August. In conclusion, this study demonstrates the presence of a broad range and high concentrations of ecdysteroids in the blood stream of wild-living passerine birds. These biologically active, anabolic compounds might possibly contribute to the known high metabolic rate of songbirds.

Bioactive Terpenes from the Soft Coral Heteroxenia sp. from Mindoro, Philippines

2000 ◽  
Vol 55 (1-2) ◽  
pp. 82-86 ◽  
Author(s):  
Ru Angelie Edrada ◽  
Victor Wray ◽  
Ludger Witte ◽  
Leen van Ofwegen ◽  
Peter Proksch
Keyword(s):  
Long Range ◽  
Brine Shrimp ◽  
Coral Species ◽  
Soft Coral ◽  
Mass Spectrometric ◽  
Biologically Active ◽  
Phytopathogenic Fungus ◽  
The Novel ◽  
Brine Shrimp Lethality ◽  
Cladosporium Cucumerinum

Abstract A marine soft coral species of the genus Heteroxenia collected from Mindoro Island, Philippines yielded two cadinene sesquiterpenes, (+)-α-m uurolene (1) and a novel derivative (+)- 6 -hydroxy-α-muurolene (2 ), as well as the biologically active polyhydroxysterol, sarcoaldosterol A (3). The structure of the novel compound was unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long range 13C -1H correlations) and mass spectrometric (EIMS) data. All compounds were active against the phytopathogenic fungus Cladosporium cucumerinum. The isolated terpenes were also active in the brine shrimp lethality test.

scholarly journals CHROMATOGRAPHIC MASS-SPECTROMETRIC STUDY OF VOLATILE EMISSIONS OF ETHER-BEARING PLANTS FOR CHEMICAL SAFETY ASSESSMENT OF THEIR USE IN ENCLOSED SPACES

2019 ◽  
Vol 96 (10) ◽  
pp. 975-979 ◽  
Author(s):  
Alla G. Malysheva ◽  
O. V. Shelepova ◽  
N. Yu. Kozlova ◽  
S. M. Yudin
Keyword(s):  
Human Health ◽  
Life Support ◽  
Mass Spectrometric ◽  
Biologically Active ◽  
Analytical Control ◽  
Toxic Substances ◽  
Chemical Safety ◽  
Volatile Emissions ◽  
Chromatographic Mass

Issues of improving the environment are now among the most important for the population of large administrative and industrial cities. Improving the quality of the environment and creating comfortable living conditions for people using environmentally friendly methods is the one of most up-to-date directions in environmental health. Improving the quality of the internal environment of the premises involves the use of various modern technical life support systems to regulate parameters of the environment. However, existing methods of cleaning and air conditioning of public and industrial premises not only fail to provide the required quality of cleaning, but also can often lead to the appearance of toxic substances, promote deionization of air and deterioration of its quality according to by biological indices. Both to clean and improve the air and give it the properties that are favorable for the life-activity of a person, phytodesign methods are used. The most popular in the gardening of interiors are tropical, subtropical and aromatic plants. Their application is due to their release in the process of vital activity in the environment of biologically active substances - phytoncides, which can improve the air composition, reduce the number of bacteria, fungi, viruses and have a therapeutic effect. Chromatographic-mass-spectrometric studies of the composition of volatile organic components of ether-bearing plants of phytocomposites, when used for artificial illumination of phytolamps with narrow spectral red and blue light, have shown that 26 organic compounds have been identified in the composition of volatile discharges of phytomodule plants grown under natural illumination. The greatest contribution to the component composition of the mixture was made by saturated hydrocarbons (36%). The contribution of oxygen-containing compounds, including phenols, was 13%, aldehydes and cyclic non-aromatic hydrocarbons -12 and 11% respectively. Despite the usefulness of additional artificial lighting for plants, an increase in the amount of substances has been established with the formation of new compounds and an increase in the total content of the identified substances. There was an increase in the content of toxic phenol (by 14 times), benzaldehyde (by 10 times) and acetophenone (by 7 times). The most hygienic significance was the group of terpenic hydrocarbons, which belongs to the group of readily convertible substances, as well as groups of oxygen-containing compounds (aldehydes, ketones, phenols, ethers), which belong to the naturally occurring entities of the toxic and dangerous groups of chemicals. More than 50% of the identified compounds did not have hygienic standards, it is not possible to assess their danger or safety for human health. The use of ether-bearing plants in closed rooms requires the chemical-analytical control of the composition of volatile emissions and the establishment of optimal conditions (saturation of plants in the room, room volume, the presence of conditioning or ozonizing units, temperature regime, humidity, etc.) in order to provide the chemical safety for human health.

scholarly journals ZOOHYGIENIC CHARACTERISTICS OF BIOTECHNOLOGICAL METHODS OF METABOLISM REGULATING OF CHICKENS EMBRYO IN THE PROCESS OF INCUBATION

2020 ◽  
pp. 100-105
Author(s):  
Olga Bordunova ◽  
Evgeniya Samokhina ◽  
Leontiі Khmelnychyi ◽  
Mykola Povod ◽  
Victoria Vechorka
Keyword(s):  
Mass Spectrometer ◽  
Gas Permeability ◽  
Experimental Studies ◽  
Mass Spectrometric ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Spectrometric Method ◽  
Mass Spectrometric Method ◽  
Hatching Eggs ◽  
Active Substances

The research presents the results of experimental studies of the influence of various physicochemical factors (phonophoresis, electrophoresis, electrospray, diffusion, etc.) on the rate of transport of biologically active substances through the protective layer of hatchig eggs shell of crossbred Haysex Brown. The aim of the study was to compare the effectiveness of the use of physicochemical methods of transportation of biologically active substances through the shell of hatching eggs of chickens. For the experiment, three batches of eggs were formed, which were obtained from layer hens Haysex Brown, 144 pieces in each experimental group. The kinetic parameters of BAS transport through bioceramic protective barriers of eggs were calculated based on the determination of BAS concentration on the surface and inside the egg by mass spectrometric method (mass spectrometer with ionization of 252Cf fission fragments "MSBH", (Ltd "SELMI", Sumy, Ukraine). The degree of permeability of bioceramic layers of the shell relative to the model gas mixture which is identical to the atmospheric air was studied by the method of V. Breslavets et other and the mass spectrometric method (gas mass spectrometer "MX 7304A"). Electron microscopic studies were performed on a scanning electron microscope REMMA-102; Visilog 6.11 (Noesis, Belgium) was used to process the obtained digital images to determine the number of shell microdefects per unit area of the digital image. It has been experimentally proved that to increase the efficiency of transport of biologically active substances (BAS) through the bioceramic layers of the shell of hatching eggs of Loman Brown hens, it is advisable to use ultrasonic treatment (phonophoresis, sonophoresis), substances - enhancers, including plant terpenes (L-menthol), DMSO and cyclodextrin. Phonophoretic treatment of hatching eggs increases the hatchability of eggs by 7.6%. At the same time, the gas permeability of the bioceramic layer increases significantly (by 0.43. 10-4 m3 / m2 s).

scholarly journals Mass spectrometric analyses of biologically active choline phospholipids and their lyso derivatives.

1983 ◽  
Vol 31 (12) ◽  
pp. 4425-4435 ◽  
Author(s):  
AKIRA TOKUMURA ◽  
YASOMI HANDA ◽  
YASUKO YOSHIOKA ◽  
HIROAKI TSUKATANI
Keyword(s):  
Mass Spectrometric ◽  
Biologically Active
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