The ACGIH Biological Exposure Index for urinary arsenic: To adjust for urinary creatinine or not?

2016 ◽  
pp. 409-410
Author(s):  
G Kew ◽  
J Myers ◽  
B Johnson
Keyword(s):  
Exposure Index ◽  
Urinary Creatinine ◽  
Urinary Arsenic ◽  
Biological Exposure Index

scholarly journals Trichloroethylene in Urine as Biological Exposure Index.

2001 ◽  
Vol 39 (3) ◽  
pp. 225-230 ◽  
Author(s):  
Marcello IMBRIANI ◽  
Qiao NIU ◽  
Sara NEGRI ◽  
Sergio GHITTORI
Keyword(s):  
Exposure Index ◽  
Biological Exposure Index

Evaluation of Current Biological Exposure Index for Occupational N, N-dimethylformamide Exposure From Synthetic Leather Workers

2004 ◽  
Vol 46 (7) ◽  
pp. 729-736 ◽  
Author(s):  
Ven-Shing Wang ◽  
Tung-Sheng Shih ◽  
Ching-Chang Cheng ◽  
Ho-Yuan Chang ◽  
Jim-Shoung Lai ◽  
...  
Keyword(s):  
Exposure Index ◽  
Synthetic Leather ◽  
Biological Exposure Index

Urinary leucine aminopeptidase 3 in population environmentally exposed to airborne arsenic

2021 ◽  
pp. 096032712098887
Author(s):  
Anna Skoczynska ◽  
Marta Skoczynska ◽  
Anna Wojakowska ◽  
Barbara Turczyn ◽  
Leszek Gruszczynski ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Model ◽  
Logistic Regression Model ◽  
Arsenic Exposure ◽  
Arsenic Species ◽  
Creatinine Concentration ◽  
Urinary Creatinine ◽  
Urinary Arsenic ◽  
Potential Biomarker ◽  
Baseline Information

Introduction: Environmental arsenic contamination is a major toxicological problem worldwide due to its carcinogenic and nephrotoxic potential. Aim: The purpose of this observational study was to determine the suspected association between urinary arsenic (uAs) and urinary leucine (or leucyl) aminopeptidase 3 (uLAP3) to evaluate uLAP3 as a candidate biomarker of exposure to airborne arsenic. Materials and Methods: A total of 918 adults occupationally and/or environmentally exposed to airborne arsenic were enrolled in the study. Baseline information (age; sex; history of smoking; alcohol, fish and seafood consumption) was gathered. Total uAs concentrations [μg/L] of 918 subjects, as well as the sum of arsenic species (ΣiAs) in 259 subjects, were obtained. Urinary LAP3 was measured by an immune-enzymatic assay using an ELISA kit. Urinary creatinine concentration was assessed with the IB/lAB/1289 research protocol (version II, 2015-09-17). The values of uAs and uLAP3 were recalculated per unit of creatinine. The association between uAs and uLAP3 was assessed using a logistic regression model adjusted for confounders. Results: The study identified a positive correlation between the logarithm of uAs and the logarithm of uLAP3 in the study population (r = 0.1737, p < 0.0000) and between urinary creatinine and uLAP3 concentration not adjusted for creatinine level (r = 0.1871, p < 0.001). In the logistic regression model, there was also an association between increased (≥15 µg/L) uAs and decreased (below the 25th quartile) uLAP3 [OR uLAP3 = 1.22 (95% CI 1.03 to 1.44, p < 0.02)]. Conclusions: These data suggest that urinary LAP3 may be a potential biomarker of arsenic exposure, which warrants further study.

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