2019 ◽  
Vol 2019 (4) ◽  
pp. 7-22
Author(s):  
Georges Bridel ◽  
Zdobyslaw Goraj ◽  
Lukasz Kiszkowiak ◽  
Jean-Georges Brévot ◽  
Jean-Pierre Devaux ◽  
...  

Abstract Advanced jet training still relies on old concepts and solutions that are no longer efficient when considering the current and forthcoming changes in air combat. The cost of those old solutions to develop and maintain combat pilot skills are important, adding even more constraints to the training limitations. The requirement of having a trainer aircraft able to perform also light combat aircraft operational mission is adding unnecessary complexity and cost without any real operational advantages to air combat mission training. Thanks to emerging technologies, the JANUS project will study the feasibility of a brand-new concept of agile manoeuvrable training aircraft and an integrated training system, able to provide a live, virtual and constructive environment. The JANUS concept is based on a lightweight, low-cost, high energy aircraft associated to a ground based Integrated Training System providing simulated and emulated signals, simulated and real opponents, combined with real-time feedback on pilot’s physiological characteristics: traditionally embedded sensors are replaced with emulated signals, simulated opponents are proposed to the pilot, enabling out of sight engagement. JANUS is also providing new cost effective and more realistic solutions for “Red air aircraft” missions, organised in so-called “Aggressor Squadrons”.


2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Hafiz Muhammad Umer Farooqi ◽  
Bohye Kang ◽  
Muhammad Asad Ullah Khalid ◽  
Abdul Rahim Chethikkattuveli Salih ◽  
Kinam Hyun ◽  
...  

AbstractHepatic fibrosis is a foreshadowing of future adverse events like liver cirrhosis, liver failure, and cancer. Hepatic stellate cell activation is the main event of liver fibrosis, which results in excessive extracellular matrix deposition and hepatic parenchyma's disintegration. Several biochemical and molecular assays have been introduced for in vitro study of the hepatic fibrosis progression. However, they do not forecast real-time events happening to the in vitro models. Trans-epithelial electrical resistance (TEER) is used in cell culture science to measure cell monolayer barrier integrity. Herein, we explored TEER measurement's utility for monitoring fibrosis development in a dynamic cell culture microphysiological system. Immortal HepG2 cells and fibroblasts were co-cultured, and transforming growth factor β1 (TGF-β1) was used as a fibrosis stimulus to create a liver fibrosis-on-chip model. A glass chip-based embedded TEER and reactive oxygen species (ROS) sensors were employed to gauge the effect of TGF-β1 within the microphysiological system, which promotes a positive feedback response in fibrosis development. Furthermore, albumin, Urea, CYP450 measurements, and immunofluorescent microscopy were performed to correlate the following data with embedded sensors responses. We found that chip embedded electrochemical sensors could be used as a potential substitute for conventional end-point assays for studying fibrosis in microphysiological systems.


2021 ◽  
pp. 153012
Author(s):  
Christian M. Petrie ◽  
Adrian M. Schrell ◽  
Donovan N. Leonard ◽  
Ying Yang ◽  
Brian C. Jolly ◽  
...  

2016 ◽  
Vol 241 ◽  
pp. 19-26 ◽  
Author(s):  
Theodore Hughes-Riley ◽  
Elizabeth R. Dye ◽  
Dario Ortega Anderez ◽  
Fraser Hill-Casey ◽  
Michael I. Newton ◽  
...  

2020 ◽  
Vol 62 (10) ◽  
pp. 1033-1040
Author(s):  
Christoph Strangfeld ◽  
Sabine Kruschwitz

Abstract The moisture content of the subfloor has to be determined before installation to avoid damage to the floor covering. Only if readiness for layering is reached, can an installation without damage be expected in all cases. In general, three approaches exist to measure residual water content: determination of moisture content, determination of water release, or determination of the corresponding relative humidity. All three approaches are tested under laboratory conditions at eight screed types including two samples thicknesses in each case. Moisture content and water release are measured by sample weighing, the corresponding relative humidity is measured by embedded sensors. All three approaches are compared and correlated. The evaluations show only a weak correlation and, in several cases, contradicting results. Samples are considered ready for layering and not ready for layering at the same time, depending on the chosen approach. Due to these contradicting results, a general threshold for a risk of damage cannot be derived based on these measurements. Furthermore, the experiment demonstrates that the measurement of corresponding relative humidity is independent of the screed type or screed composition considered. This makes humidity measurement a potentially very promising approach for the installation of material moisture monitoring systems.


Sign in / Sign up

Export Citation Format

Share Document