Impact of MicroRNAs in Synaptic Plasticity, Major Affective Disorders, and Suicidal Behavior

2016 ◽  
pp. 101-135
Author(s):  
Gianluca Serafini ◽  
Yogesh Dwivedi ◽  
Mario Amore
Keyword(s):  
Synaptic Plasticity ◽  
Suicidal Behavior ◽  
Affective Disorders

The role of microRNAs in synaptic plasticity, major affective disorders and suicidal behavior

2012 ◽  
Vol 73 (3) ◽  
pp. 179-190 ◽  
Author(s):  
Gianluca Serafini ◽  
Maurizio Pompili ◽  
Marco Innamorati ◽  
Gloria Giordano ◽  
Franco Montebovi ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Suicidal Behavior ◽  
Affective Disorders

scholarly journals Can Anhedonia Be Considered a Suicide Risk Factor? A Review of the Literature

Medicina ◽  
2019 ◽  
Vol 55 (8) ◽  
pp. 458 ◽  
Author(s):  
Bonanni ◽  
Gualtieri ◽  
Lester ◽  
Falcone ◽  
Nardella ◽  
...  
Keyword(s):  
Suicidal Behavior ◽  
Affective Disorders ◽  
Suicide Attempts ◽  
Positive Association ◽  
Negative Association ◽  
Schizophrenia Spectrum Disorders ◽  
Post Traumatic Stress ◽  
Significant Positive Association ◽  
Search Terms ◽  
Schizophrenia Spectrum

Background and Objectives: At present, data collected from the literature about suicide and anhedonia are controversial. Some studies have shown that low levels of anhedonia are associated with serious suicide attempts and death by suicide, while other studies have shown that high levels of anhedonia are associated with suicide. Materials and Methods: For this review, we searched PubMed, Medline, and ScienceDirect for clinical studies published from 1 January 1990 to 31 December 2018 with the following search terms used in the title or in the abstract: “anhedonia AND suicid*.” We obtained a total of 155 articles; 133 items were excluded using specific exclusion criteria, the remaining 22 articles included were divided into six groups based on the psychiatric diagnosis: mood disorders, schizophrenia spectrum disorders, post-traumatic stress disorder (PTSD), other diagnoses, attempted suicides, and others (healthy subjects). Results: The results of this review reveal inconsistencies. Some studies reported that high anhedonia scores were associated with suicidal behavior (regardless of the diagnosis), while other studies found that low anhedonia scores were associated with suicidal behavior, and a few studies reported no association. The most consistent association between anhedonia and suicidal behavior was found for affective disorders (7 of 7 studies reported a significant positive association) and for PTSD (3 of 3 studies reported a positive association). In the two studies of patients with schizophrenia, one found no association, and one found a negative association. For patients who attempted suicide (undiagnosed), one study found a positive association, one a positive association only for depressed attempters, and one a negative association. Conclusions: We found the most consistent positive association for patients with affective disorders and PTSD, indicating that the assessment of anhedonia may be useful in the evaluation of suicidal risk.

scholarly journals Association Study of Suicidal Behavior and Affective Disorders with a Genetic Polymorphism in ABCG1, a Positional Candidate on Chromosome 21q22.3

2000 ◽  
Vol 42 (1) ◽  
pp. 22-25 ◽  
Author(s):  
D. Rujescu ◽  
I. Giegling ◽  
N. Dahmen ◽  
A. Szegedi ◽  
I. Anghelescu ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Association Study ◽  
Suicidal Behavior ◽  
Affective Disorders ◽  
Positional Candidate

scholarly journals Do risk factors for suicidal behavior differ by affective disorder polarity?

2008 ◽  
Vol 39 (5) ◽  
pp. 763-771 ◽  
Author(s):  
J. G. Fiedorowicz ◽  
A. C. Leon ◽  
M. B. Keller ◽  
D. A. Solomon ◽  
J. P. Rice ◽  
...  
Keyword(s):  
Risk Factors ◽  
Substance Abuse ◽  
Affective Disorder ◽  
Suicidal Behavior ◽  
Active Substance ◽  
Affective Disorders ◽  
Suicide Risk ◽  
Suicide Attempts ◽  
Age Of Onset ◽  
Suicide Risk Factors

BackgroundSuicide is a leading cause of death and has been strongly associated with affective disorders. The influence of affective disorder polarity on subsequent suicide attempts or completions and any differential effect of suicide risk factors by polarity were assessed in a prospective cohort.MethodParticipants with major affective disorders in the National Institute of Mental Health (NIMH) Collaborative Depression Study (CDS) were followed prospectively for up to 25 years. A total of 909 participants meeting prospective diagnostic criteria for major depressive and bipolar disorders were followed through 4204 mood cycles. Suicidal behavior was defined as suicide attempts or completions. Mixed-effects, grouped-time survival analysis assessed risk of suicidal behavior and differential effects of risk factors for suicidal behavior by polarity. In addition to polarity, the main effects of age, gender, hopelessness, married status, prior suicide attempts and active substance abuse were modeled, with mood cycle as the unit of analysis.ResultsAfter controlling for age of onset, there were no differences in prior suicide attempts by polarity although bipolar participants had more prior severe attempts. During follow-up, 40 cycles ended in suicide and 384 cycles contained at least one suicide attempt. Age, hopelessness and active substance abuse but not polarity predicted suicidal behavior. The effects of risk factors did not differ by polarity.ConclusionsBipolarity does not independently influence risk of suicidal behavior or alter the influence of well-established suicide risk factors within affective disorders. Suicide risk assessment strategies may continue to appraise these common risk factors without regard to mood polarity.

1198 – The role of micrornas in major affective disorders and suicidal behavior

2013 ◽  
Vol 28 ◽  
pp. 1
Author(s):  
G. Serafini ◽  
M. Pompili ◽  
M. Innamorati ◽  
P. Girardi
Keyword(s):  
Suicidal Behavior ◽  
Affective Disorders

The study of suicidal behavior at patients with anhedonia in schizophrenia

2011 ◽  
Vol 26 (S2) ◽  
pp. 1464-1464
Author(s):  
N. Orlova ◽  
M. Shkliar ◽  
E. Khaustova
Keyword(s):  
Risk Factor ◽  
Suicidal Behavior ◽  
Affective Disorders ◽  
Negative Symptoms ◽  
Paranoid Schizophrenia ◽  
Illness Duration ◽  
The Past ◽  
Suicidal Attempts ◽  
Suicidal Ideas ◽  
Suicide Plan

IntroductionThe suicidal behavior at patients with anhedonia in schizophrenia is one of the burn problems in modern psychiatry.ObjectivesAnhedonia belongs to negative symptoms in schizophrenia. The suicidal activity at patients with it consists from 7% tо 43%. At those patients fixed the suicidal ideas - 40%, suicidal attempts - 23% and complete suicide - 6,4%.AimsStudy the methods of suicidal behavior at those patients.MethodsThe Columbia Suicide severity research scale (C-SSRS).Results157 patients with anhedonia. Selected 49 (31, 21%) patients with suicidal behavior on admission or in the past. 23 women and 26 men with a mean age of 34, 37(±1, 92) and mean illness duration of 7, 72(±1, 42). The anhedonia level was 21, 26(±1, 26). 73,48% were the patients with Schizophrenia among them 44,91% with “postpsychotic depression” (295.60), 28, 57% with paranoid schizophrenia (295.30) and 26,52% - patients with affective disorders (296.3×). All patients wished to die. 79,59% (n = 39) had a suicidal attempts and 20,41% (n = 10) had a suicidal ideas. Active suicidal ideas without the suicide plan had 79, 59% patients. The methods of suicidal attempts were poisoning (38, 52%), cutting (25, 64%), hanging (12, 8%), falls (20, 48%), drowning (2, 56%).ConclusionsAnhedonia in schizophrenia is a risk factor of suicidal behavior. The suicidal behavior declared itself with suicidal attempts much more than suicidal ideas. Suicidal attempts were impulsive and dangerous with risk for life. It point to seriousness and danger results of suicidal behavior.

Differential associations of affective temperaments and diagnosis of major affective disorders with suicidal behavior

2017 ◽  
Vol 210 ◽  
pp. 19-21 ◽  
Author(s):  
Ross J. Baldessarini ◽  
Marco Innamorati ◽  
Denise Erbuto ◽  
Gianluca Serafini ◽  
Andrea Fiorillo ◽  
...  
Keyword(s):  
Suicidal Behavior ◽  
Affective Disorders ◽  
Affective Temperaments

The impact of neuroinflammation and inflammatory cytokines in depression and suicidal behavior

2016 ◽  
Vol 33 (S1) ◽  
pp. S160-S160
Author(s):  
G. Serafini ◽  
M. Pompili ◽  
P. Girardi ◽  
M. Amore
Keyword(s):  
Suicidal Ideation ◽  
Major Depression ◽  
Inflammatory Cytokines ◽  
Suicidal Behavior ◽  
Affective Disorders ◽  
Molecular Mechanisms ◽  
Major Depressive ◽  
Competing Interest ◽  
Activation Pathways ◽  
The Impact

IntroductionIt has been suggested that neuroinflammation and inflammatory mediators may play a crucial role in the pathophysiology of both major depression and suicidal behavior. Immunological differences have been reported between both subjects with major affective disorders and suicidal behavior.ObjectivesThe main objective of this review was to deeply investigate the nature of the association between inflammatory cytokines in depression and suicidal behavior. Aims: The study aimed to conduct a systematic review of the current literature to investigate the association between inflammatory cytokines, depression, and suicidal behavior.ResultsGenerally, an imbalance between pro-inflammatory and anti-inflammatory cytokines has been documented in both major depression and suicidal behavior. The presence of major depressive disorder (MDD) with suicidal ideation/attempts was associated with differences in inflammatory cytokine profile when compared to that without suicidal ideation/attempts. However, not all studies demonstrated a positive correlation between inflammatory cytokines and suicidal behavior.ConclusionsThe mentioned association between inflammatory cytokines, depression, and suicidal behavior does not imply the existence of a causal relationship. Further additional studies should clarify the molecular mechanisms of the immune activation pathways underlying depression and suicidality.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Association between suicidal behavior and genes of serotonergic system confirmed in men with affective disorders

2014 ◽  
Vol 83 (1) ◽  
pp. 7-16
Author(s):  
Joanna Pawlak ◽  
Monika Dmitrzak-Węglarz ◽  
Maria Skibinska ◽  
Aleksandra Szczepankiewicz ◽  
Anna Leszczynska-Rodziewicz ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Suicidal Behavior ◽  
Affective Disorders ◽  
Psychotic Disorders ◽  
Tryptophan Hydroxylase ◽  
Suicide Attempts ◽  
Clinical Problem ◽  
Serotonergic System ◽  
Type I ◽  
Nucleotide Polymorphisms

Introduction. Suicidal behavior is a crucial clinical problem in many groups of psychiatric patients. It occurs most often in affective disorders, psychotic disorders, substance abuse/dependence and personality disorders. Although not all patients with these diagnoses present suicidal behavior, it is very important to find the most vulnerable subgroups. The extensive number of studies shows that suicidal behavior (completed and attempted suicide) is associated with changes in functioning of serotonergic system. Tryptophan hydroxylase (TPH) is rate-limiting enzyme in biosynthesis of serotonin. Serotonin transporter (5-HTT) is the main factor removing serotonin from the synaptic space. Genetic studies confirm that suicide behavior has a genetic component independently of major psychiatric disorders. Aim. The aim of this study is to look for association between selected candidate genes and suicidal behavior in affective disorders.Material and methods. In the study we included 597 patients meeting DSM-IV criteria for bipolar disorder or unipolar disorder and 563 healthy controls. Polymorphism of serotonin transporter gene 5-HTTLPR and single nucleotide polymorphisms – SNPs (rs1799913 and rs1800532) in tryptophan hydroxylase 1 (TPH1) gene were analyzed. We used in computation Statistica 8.0 package (STATSOFT, Poland) (tests: The two-tailed Pearson's chi-square (?2) test and Fisher's exact test).Results. Main positive findings are an association between TPH1 polymorphisms and bipolar disease type I (BPI) diagnosis in men and an association between TPH1 polymorphisms and suicidal attempts in male patients. In all group we did not find nor allelic neither genotypic associations of selected polymorphisms and diagnosis or suicide attempts. Conclusions. Our findings partially confirm that serotonergic system plays a role in affective disorder and suicidal behavior, but the association needs further investigation.

scholarly journals Predictors of suicidal behavior in patients with cognitive impairments in depressive disorders

2020 ◽  
Vol 24 (4 (96)) ◽  
pp. 58-64
Author(s):  
N. Maruta ◽  
S. Yaroslavtsev
Keyword(s):  
Cognitive Impairment ◽  
Depressive Disorder ◽  
Interpersonal Relationships ◽  
Suicidal Behavior ◽  
Cognitive Functions ◽  
Affective Disorders ◽  
Suicide Risk ◽  
Depressive Disorders ◽  
Bipolar Affective Disorder ◽  
Autonomic Disorders

The aim of the study was to determine predictors of suicide risk in patients with cognitive impairment in depressive disorders.Material and methods. 362 patients with cognitive impairment in depressive disorders were examined: 123 patients with recurrent depressive disorder, 141 patients with bipolar affective disorder and 98 patients with prolonged depressive reaction. A set of research methods was used to study the factors of suicidal behavior in patients with cognitive impairment in depressive disorders: clinical-psychopathological, psychodiagnostic (questionnaire "Self-assessment of the severity of autoaggressive predictors") and mathematical-statistical. Results of the research. Predictors of suicide risk in patients with cognitive impairment in depressive disorders were identified. The moderate level of autoaggression and aggression, low level of impulsivity, high and severe narrowing of cognitive functions, severe narrowing of interpersonal relationships, severity of affective disorders, moderate and severe autonomic disorders were identified in patients with recurrent depressive disorder. Pronounced and moderate level of autoaggression, aggression and impulsivity, high and pronounced level of narrowing of cognitive functions, pronounced narrowing of interpersonal relationships, severity of affective disorders, moderate and severe level of autonomic disorders were identified in patients with bipolar affective disorder. Moderate levels of autoaggression and narrowing of cognitive functions, low levels of aggression, severe impulsivity, affective disorders and narrowing of interpersonal relationships, and high levels of autonomic disorders were identified in patients with prolonged depressive reaction.Conclusions. As a result of the study, the features of suicidal behavior in patients with cognitive impairment in depressive disorders were identified. It can act as diagnostic criteria and predictors of suicidal behavior in differential diagnostics and could take into account when creating psychocorrectional programs aimed at reducing suicidal risk in patients with cognitive dysfunctions in depressive disorders.

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