Enhancing Detection Versatility: MC-CE Device with Serial Dual-Electrode Detection for Determining Glutathione Disulfide and Glutathione in Pharmaceutical Supplement

2015 ◽  
pp. 166-185
Keyword(s):  
Glutathione Disulfide

scholarly journals Regulation of liver phosphorylase phosphatase by glutathione disulfide.

1980 ◽  
Vol 255 (5) ◽  
pp. 1928-1931
Author(s):  
M. Usami ◽  
H. Matsushita ◽  
T. Shimazu
Keyword(s):  
Glutathione Disulfide

scholarly journals Oxidative Stress in Rats After 60 Days of Hypergalactosemia or Hyperglycemia

2003 ◽  
Vol 22 (6) ◽  
pp. 423-427 ◽  
Author(s):  
Mary Otsyula ◽  
Matthew S. King ◽  
Tonya G. Ketcham ◽  
Ruth A. Sanders ◽  
John B. Watkins
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Insulin Treatment ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Glutathione Disulfide ◽  
Hepatic Lipid Peroxidation ◽  
Streptozotocin Diabetic Rats

Two of the models used in current diabetes research include the hypergalactosemic rat and the hyperglucosemic, streptozotocin-induced diabetic rat. Few studies, however, have examined the concurrence of these two models regarding the effects of elevated hexoses on biomarkers of oxidative stress. This study compared the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase and the concentrations of glutathione, glutathione disulfide, and thiobarbituric acid reactants (as a measure of lipid peroxidation) in liver, kidney, and heart of Sprague-Dawley rats after 60 days of either a 50% galactose diet or insulin deficiency caused by streptozotocin injection. Most rats from both models developed bilateral cataracts. Blood glucose and glycosy-lated hemoglobin A1c concentrations were elevated in streptozotocin diabetic rats. Streptozotocin diabetic rats exhibited elevated activities of renal superoxide dismutase, cardiac catalase, and renal and cardiac glutathione peroxidase, as well as elevated hepatic lipid peroxidation. Insulin treatment of streptozotocin-induced diabetic rats normalized altered markers. In galactosemic rats, hepatic lipid peroxidation was increased whereas glutathione reductase activity was diminished. Glutathione levels in liver were decreased in diabetic rats but elevated in the galactosemic rats, whereas hepatic glutathione disulfide concentrations were decreased much more in diabetes than in galactosemia. Insulin treatment reversed/prevented all changes caused by streptozotocin-induced diabetes. Lack of concomitance in these data indicate that the 60-day galactose-fed rat is not experiencing the same oxidative stress as the streptozotocin diabetic rat, and that investigators must be cautious drawing conclusions regarding the concurrence of the effects of the two animal models on oxidative stress biomarkers.

scholarly journals Simultaneous Biochemical and Physiological Responses of the Roots and Leaves of Pancratium maritimum (Amaryllidaceae) to Mild Salt Stress

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 345
Author(s):  
Simona Carfagna ◽  
Giovanna Salbitani ◽  
Michele Innangi ◽  
Bruno Menale ◽  
Olga De Castro ◽  
...  
Keyword(s):  
Salt Stress ◽  
Reduced Glutathione ◽  
Physiological Responses ◽  
Leaf Tissue ◽  
Electron Donors ◽  
Organic Osmolytes ◽  
Glutathione Disulfide ◽  
Stress Changes ◽  
Leaves And Roots ◽  
Pancratium Maritimum

Pancratium maritimum (Amaryllidaceae) is a bulbous geophyte growing on coastal sands. In this study, we investigated changes in concentrations of metabolites in the root and leaf tissue of P. maritimum in response to mild salt stress. Changes in concentrations of osmolytes, glutathione, sodium, mineral nutrients, enzymes, and other compounds in the leaves and roots were measured at 0, 3, and 10 days during a 10-day exposure to two levels of mild salt stress, 50 mM NaCl or 100 mM NaCl in sandy soil from where the plants were collected in dunes near Cuma, Italy. Sodium accumulated in the roots, and relatively little was translocated to the leaves. At both concentrations of NaCl, higher values of the concentrations of oxidized glutathione disulfide (GSSG), compared to reduced glutathione (GSH), in roots and leaves were associated with salt tolerance. The concentration of proline increased more in the leaves than in the roots, and glycine betaine increased in both roots and leaves. Differences in the accumulation of organic osmolytes and electron donors synthesized in both leaves and roots demonstrate that osmoregulatory and electrical responses occur in these organs of P. maritimum under mild salt stress.

Glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic AND logic gate for smart delivery

Nanoscale ◽  
2021 ◽  
Author(s):  
Beatriz Mayol ◽  
Paula Diez ◽  
Alfredo Sánchez ◽  
Cristina De La Torre Paredes ◽  
Anabel Villalonga ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Logic Gate ◽  
Boolean Logic ◽  
Glutathione Disulfide ◽  
Janus Nanoparticles

This work describes the assembly of a novel enzyme-controlled nanomachine operated through an AND Boolean logic gate for on-command delivery. The nanodevice was constructed on Au-mesoporous silica Janus nanoparticles capped...

Increased Biliary Glutathione Disulfide (GSSG) Release in Chronically Ethanol-Treated Rats

1980 ◽  
pp. 619-625
Author(s):  
Osvaldo R. Koch ◽  
Elba Martino ◽  
Alberto Boveris ◽  
Helmut Sies
Keyword(s):  
Glutathione Disulfide

The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress

2001 ◽  
Vol 76 (2) ◽  
pp. 627-636 ◽  
Author(s):  
Johannes Hirrlinger ◽  
Jörg König ◽  
Dietrich Keppler ◽  
Jörg Lindenau ◽  
Jörg B. Schulz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multidrug Resistance ◽  
Multidrug Resistance Protein ◽  
Glutathione Disulfide ◽  
Rat Astrocytes ◽  
Resistance Protein
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