Glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic AND logic gate for smart delivery

Nanoscale ◽  
2021 ◽  
Author(s):  
Beatriz Mayol ◽  
Paula Diez ◽  
Alfredo Sánchez ◽  
Cristina De La Torre Paredes ◽  
Anabel Villalonga ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Logic Gate ◽  
Boolean Logic ◽  
Glutathione Disulfide ◽  
Janus Nanoparticles

This work describes the assembly of a novel enzyme-controlled nanomachine operated through an AND Boolean logic gate for on-command delivery. The nanodevice was constructed on Au-mesoporous silica Janus nanoparticles capped...

scholarly journals Synthesis of colloidal Janus nanoparticles by asymmetric capping of mesoporous silica with phenylsilsesquioxane

2015 ◽  
Vol 51 (15) ◽  
pp. 3211-3214 ◽  
Author(s):  
Hiroto Ujiie ◽  
Atsushi Shimojima ◽  
Kazuyuki Kuroda
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Aqueous Dispersion ◽  
Composite Nanoparticles ◽  
Mesostructured Silica ◽  
Janus Nanoparticles

Janus-type mesoporous silica nanoparticles asymmetrically capped with non-porous phenylsilsesquioxane have been prepared by simply adding phenyltriethoxysilane to an aqueous dispersion of mesostructured silica–surfactant composite nanoparticles.

scholarly journals The intersectional genetics landscape for human

2019 ◽  
Author(s):  
Andre Macedo ◽  
Alisson M. Gontijo
Keyword(s):  
Gene Expression ◽  
Therapeutic Potential ◽  
Regulatory Element ◽  
Logic Gate ◽  
Cell Types ◽  
Boolean Logic ◽  
Interindividual Variation ◽  
Model Organisms ◽  
Cell Type ◽  
Diagnostic Potential

The human body is made up of hundreds, perhaps thousands of cell types and states, most of which are currently inaccessible genetically. Genetic accessibility carries significant diagnostic and therapeutic potential by allowing the selective delivery of genetic messages or cures to cells. Research in model organisms has shown that single regulatory element (RE) activities are seldom cell type specific, limiting their usage in genetic systems designed to restrict gene expression posteriorly to their delivery to cells. Intersectional genetic approaches can increase the number of genetically accessible cells. A typical intersectional method acts like an AND logic gate by converting the input of two or more active REs into a single synthetic output, which becomes unique for that cell. Here, we systematically assessed the intersectional genetics landscape of human using a curated subset of cells from a large RE usage atlas obtained by Cap Analysis of Gene Expression Sequencing (CAGE-Seq) of thousands of primary and cancer cells (the FANTOM5 consortium atlas). We developed the heuristics and algorithms to retrieve and quality rank AND gate intersections intra- and inter-individually. We find that >90% of the 154 primary cell types surveyed can be distinguished from each other with as little as 3 to 4 active REs, with quantifiable safety and robustness. We call these minimal intersections of active REs with cell-type diagnostic potential “Versatile Entry Codes” (VEnCodes). We show that VEnCodes could be found for 100% of the 158 cancer cell types surveyed, and that most of these are highly robust to intra- and interindividual variation. Our tools for generating and quality-ranking VEnCodes can be adapted to other RE usage databases and to other intersectional methods using alternative Boolean logic operations. Our work demonstrate the potential of intersectional approaches for future gene delivery technologies in human.

scholarly journals Long starphene single molecule NOR Boolean logic gate

2018 ◽  
Vol 678 ◽  
pp. 163-168 ◽  
Author(s):  
W.H. Soe ◽  
C. Manzano ◽  
P. de Mendoza ◽  
P.R. McGonigal ◽  
A.M. Echavarren ◽  
...  
Keyword(s):  
Single Molecule ◽  
Logic Gate ◽  
Boolean Logic

A pyrene-benzimidazole composed effective fluoride sensor: potential mimicking of a Boolean logic gate

2018 ◽  
Vol 42 (11) ◽  
pp. 9200-9208 ◽  
Author(s):  
Archana Kushwaha ◽  
Sagar K. Patil ◽  
Dipanwita Das
Keyword(s):  
Logic Gate ◽  
Memory Function ◽  
Boolean Logic ◽  
Fluoride Sensor

A highly selective fluoride sensor based on a pyrene benzimidazole unit was developed and studied for recyclable memory function.

scholarly journals Quantum half-adder Boolean logic gate with a nano-graphene molecule and graphene nano-electrodes

2017 ◽  
Vol 667 ◽  
pp. 301-306 ◽  
Author(s):  
Saurabh Srivastava ◽  
Hiori Kino ◽  
Christian Joachim
Keyword(s):  
Logic Gate ◽  
Boolean Logic ◽  
Half Adder ◽  
Nano Graphene

The mathematics of a quantum Hamiltonian computing half adder Boolean logic gate

2015 ◽  
Vol 26 (34) ◽  
pp. 344003 ◽  
Author(s):  
G Dridi ◽  
R Julien ◽  
M Hliwa ◽  
C Joachim
Keyword(s):  
Logic Gate ◽  
Boolean Logic ◽  
Half Adder ◽  
Quantum Hamiltonian

scholarly journals High Speed All-Optical Logic Gate Using QD-SOA and its Application

2017 ◽  
Author(s):  
Shuai Zhao ◽  
Hongyu Hu
Keyword(s):  
High Speed ◽  
Logic Gate ◽  
Logic Gates ◽  
Boolean Logic ◽  
Hole Burning ◽  
Spectral Hole Burning ◽  
Optical Logic ◽  
Carrier Heating ◽  
Optical Logic Gates ◽  
All Optical

The scheme to realize high speed (~250Gb/s) all-optical Boolean logic gates using semiconductor optica amplifiers with quantum-dot (QD-SOA) is introduced and analyzed in this review. Numerical simulation method was presented by solving the rate equation and taking into account nonlinear dynamics including carrier heating and spectral hole-burning. Binary phase shift keyed (BPSK) signal and on-off keyed signal are used to generate high speed all-optical logic gates. The applications based on all-optical logic gates such as, all-optical latches, pseudo random bit sequence (PRBS) generation and all-optical encryption, are also discussed in this review. Results show that the scheme based on QD-SOA is a promising method for the realization of high speed all-optical communication system in the future.

scholarly journals Engineering the Stability of Nanozyme-Catalyzed Product for Colorimetric Logic Gate Operations

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6494
Author(s):  
Lianlian Fu ◽  
Deshuai Yu ◽  
Dijuan Zou ◽  
Hao Qian ◽  
Youhui Lin
Keyword(s):  
Glucose Oxidase ◽  
Xanthine Oxidase ◽  
Color Change ◽  
Logic Gate ◽  
Logic Gates ◽  
Boolean Logic ◽  
Blue Color ◽  
Push Forward ◽  
Logic Operations ◽  
The Stability

Recently, the design and development of nanozyme-based logic gates have received much attention. In this work, by engineering the stability of the nanozyme-catalyzed product, we demonstrated that the chromogenic system of 3, 3′, 5, 5′-tetramethylbenzidine (TMB) can act as a visual output signal for constructing various Boolean logic operations. Specifically, cerium oxide or ferroferric oxide-based nanozymes can catalyze the oxidation of colorless TMB to a blue color product (oxTMB). The blue-colored solution of oxTMB could become colorless by some reductants, including the reduced transition state of glucose oxidase and xanthine oxidase. As a result, by combining biocatalytic reactions, the color change of oxTMB could be controlled logically. In our logic systems, glucose oxidase, β-galactosidase, and xanthine oxidase acted as inputs, and the state of oxTMB solution was used as an output. The logic operation produced a colored solution as the readout signal, which was easily distinguished with the naked eye. More importantly, the study of such a decolorization process allows the transformation of previously designed AND and OR logic gates into NAND and NOR gates. We propose that this work may push forward the design of novel nanozyme-based biological gates and help us further understand complex physiological pathways in living systems.

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