Ensuring optimal hydraulic and thermal regimes in district heating systems (DHS) in the regulation of heat supply is an important factor in improving the energy and economic efficiency of DHS. In addition, high efficiency of the HS system is a factor that can ensure the preservation of its vital functions. Solving the problem of increasing the energy efficiency of the heat supply system is a complex problem that requires changes at all stages of heat transformation: in the energy source, heating networks and subscriber heating systems of heat consumers. The purpose of this study is to identify the impact of heat dissipation control processes in district heating systems on their energy and economic efficiency, provide recommendations for improving control processes taking into account modern challenges and regulatory requirements, analyze heat dissipation temperature schedules and select the optimal temperature schedule. It is shown that the optimal is the combined quantitative and qualitative regulation of heat release, which should be carried out both at the energy source and at consumers. The paper considers the possibility of using combined control systems in the existing district heating systems of Ukrainian cities. It is shown that the achievement of high energy efficiency is possible only with the introduction of automatic individual heating points with weather control and pressure drop regulators at the inlet to the buildings in the subscriber heating systems. Calculations of the amount of heat consumption reduction of centralized heat supply systems with the introduction of optimal control systems are performed.