Vertical reduction rectoplasty for idiopathic megarectum

Author(s):  
Marc Gladman ◽  
Norman Williams
2000 ◽  
Vol 87 (9) ◽  
pp. 1203-1208 ◽  
Author(s):  
N. S. Williams ◽  
O. A. Fajobi ◽  
P. J. Lunniss ◽  
S. M. Scott ◽  
A. J. P. Eccersley ◽  
...  

2021 ◽  
Vol 14 (6) ◽  
pp. e240209
Author(s):  
Maureen Elvira Padernal Villanueva ◽  
Marc Paul Jose Lopez ◽  
Mark Augustine S Onglao

Idiopathic megacolon (IMC) and idiopathic megarectum (IMR) describe an abnormality of the colon or rectum, characterised by a permanent dilatation of the bowel diameter in the absence of an identifiable cause. We present a 23-year-old woman with chronic constipation and excessive straining during defecation who presented at the emergency department in partial gut obstruction with a palpable fecaloma. Manual faecal disimpaction and a sigmoid loop colostomy was initially done. A full thickness rectal biopsy was positive for ganglion cells. Further workup led to the diagnosis of chronic IMC and IMR. The patient underwent laparoscopic modified Duhamel procedure, with an uneventful postoperative course.


2019 ◽  
Vol 54 (7) ◽  
pp. 1379-1383 ◽  
Author(s):  
Igor V. Kirgizov ◽  
Sergey V. Minaev ◽  
Ilya Shishkin ◽  
Svetlana Aprosimova ◽  
Luiza Ukhina

2005 ◽  
Vol 241 (4) ◽  
pp. 562-574 ◽  
Author(s):  
Marc A. Gladman ◽  
S Mark Scott ◽  
Peter J. Lunniss ◽  
Norman S. Williams

1996 ◽  
Vol 11 (6) ◽  
pp. 264-271 ◽  
Author(s):  
J. M. Gattuso ◽  
C. H. V. Hoyle ◽  
P. Milner ◽  
M. A. Kamm ◽  
G. Burnstock

1992 ◽  
Vol 35 (2) ◽  
pp. 158-162 ◽  
Author(s):  
Giorgio Stabile ◽  
Michael A. Kamm ◽  
Robin K. S. Phillips ◽  
Peter R. Hawley ◽  
John E. Lennard-Jones

1991 ◽  
Vol 78 (6) ◽  
pp. 661-663 ◽  
Author(s):  
G. Stabile ◽  
M. A. Kamm ◽  
P. R. Hawley ◽  
J. E. Lennard-Jones

2005 ◽  
Vol 92 (5) ◽  
pp. 624-630 ◽  
Author(s):  
M. A. Gladman ◽  
N. S. Williams ◽  
S. M. Scott ◽  
O. A. Ogunbiyi ◽  
P. J. Lunniss

Gut ◽  
1997 ◽  
Vol 41 (2) ◽  
pp. 252-257 ◽  
Author(s):  
J M Gattuso ◽  
M A Kamm ◽  
I C Talbot

Background—The aetiology and pathology of both idiopathic megarectum and idiopathic megacolon are unknown. In particular, it is unknown whether there are abnormalities involving enteric nerves or smooth muscle.Methods—Resected tissue was examined from 24 patients who underwent surgery for idiopathic megarectum, from six patients who had tissue resected for idiopathic megacolon, and 17 control patients who had surgery for non-obstructing large bowel cancer. Qualitative and quantitative histological examination was performed after staining with haematoxylin and eosin, periodic acid Schiff (PAS), Martius scarlet blue (MSB), and phosphotungstic acid haematoxylin (PTAH). Neural and glial tissue were examined after immunostaining with S100 and PGP9.5.Results—Compared with controls, patients with idiopathic megarectum had significant thickening of their muscularis mucosae (median 78 v 33 μm, p<0.005), circular muscle (1000 v 633 μm, p<0.005), and longitudinal muscle (1083v 303 μm, p<0.005), despite rectal dilatation. This thickening was relatively greater in the longitudinal than in the circular muscle. Fibrosis of the longitudinal muscle was seen, using MSB staining, in 58%, of circular muscle in 38%, and of muscularis mucosae in 29% of patients. The relation between muscle thickening and fibrosis was variable. The density of neural tissue in the longitudinal muscle seemed to be reduced in patients with idiopathic megarectum. There was no thickening of enteric muscle or alteration in the density of innervation in patients with idiopathic megacolon.Conclusion—There is notable thickening of the enteric smooth muscle in patients with idiopathic megarectum, but the architecture of the enteric innervation seems to be intact. Functional abnormalities of the latter remain a possible cause of the smooth muscle hypertrophy.


1992 ◽  
Vol 7 (2) ◽  
pp. 82-84 ◽  
Author(s):  
G. Stabile ◽  
M. A. Kamm ◽  
P. R. Hawley ◽  
J. E. Lennard-Jones

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