Neurological development

2014 ◽  
pp. 11-36
Author(s):  
Allan Hobson
Keyword(s):  
Neurological Development

scholarly journals Adenosine-to-inosine RNA editing in neurological development and disease

RNA Biology ◽  
2021 ◽  
pp. 1-15
Author(s):  
Yuxi Yang ◽  
Shunpei Okada ◽  
Masayuki Sakurai
Keyword(s):  
Rna Editing ◽  
Neurological Development

scholarly journals Secondary Myelitis in Dermal Sinus Causing Paraplegia in a Child with Previously Normal Neurological Function

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Sakina Rashid ◽  
Grace Kinabo ◽  
Marissa Kellogg ◽  
William P. Howlett ◽  
Marieke C. J. Dekker
Keyword(s):  
Congenital Anomaly ◽  
Spina Bifida ◽  
Neural Tube ◽  
Clinical Course ◽  
Acute Infection ◽  
Early Embryogenesis ◽  
The Other ◽  
Neurological Deficits ◽  
Dermal Sinus ◽  
Neurological Development

Neural tube defects result from failure of neural tube fusion during early embryogenesis, the fourth week after conception. The spectrum of severity is not uniform across the various forms of this congenital anomaly as certain presentations are not compatible with extrauterine life (anencephaly) while, on the other hand, other defects may remain undiagnosed as they are entirely asymptomatic (occult spina bifida). We report a child with previously normal neurological development, a devastating clinical course following superinfection of a subtle spina bifida defect which resulted in a flaccid paralysis below the level of the lesion and permanent neurological deficits following resolution of the acute infection and a back closure surgery.

Adolescent Neurological Development and its Implications for Adolescent Substance Use Prevention

2008 ◽  
Vol 29 (1) ◽  
pp. 5-35 ◽  
Author(s):  
Barbara Lopez ◽  
Seth J. Schwartz ◽  
Guillermo Prado ◽  
Ana E. Campo ◽  
Hilda Pantin
Keyword(s):  
Substance Use ◽  
Adolescent Substance Use ◽  
Neurological Development ◽  
Substance Use Prevention ◽  
Adolescent Substance

Neurological Development in Congenital Hypothyroidism

1989 ◽  
pp. 301-308 ◽  
Author(s):  
Pierre Rochiccioli ◽  
Françoise Alexandre ◽  
Bernadette Rogé
Keyword(s):  
Congenital Hypothyroidism ◽  
Neurological Development

scholarly journals Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development

PLoS Genetics ◽  
2018 ◽  
Vol 14 (11) ◽  
pp. e1007817 ◽  
Author(s):  
Mia J. Konjikusic ◽  
Patra Yeetong ◽  
Curtis W. Boswell ◽  
Chanjae Lee ◽  
Elle C. Roberson ◽  
...  
Keyword(s):  
Family Member ◽  
Ependymal Cell ◽  
Specific Role ◽  
Neurological Development ◽  
Kinesin Family

scholarly journals Influence of intracranial hemorrhage and neonatal seizures on the neurological and psychomotor development of premature infants at Hospital de Clínicas de Porto Alegre, Brazil

2003 ◽  
Vol 61 (4) ◽  
pp. 902-905 ◽  
Author(s):  
Lygia Ohlweiler ◽  
Alexandre Rodrigues da Silva ◽  
Sonja Vergínia Barros ◽  
Rudimar Riesgo ◽  
Newra Tellechea Rotta
Keyword(s):  
Intracranial Hemorrhage ◽  
Premature Infants ◽  
Muscle Tone ◽  
Outpatient Service ◽  
Psychomotor Development ◽  
Neonatal Seizures ◽  
Neurological Development ◽  
Porto Alegre ◽  
The Difference ◽  
Periventricular Hemorrhage

This study compared the results of neurodevelopmental examination at 6 months' corrected age of premature infants with neonatal seizures and/or intracranial hemorrhage and normal premature infants. There was a statistically significant correlation (p=0.000007) between intracranial hemorrhage and seizures in the group of 68 premature infants seen in the neurodevelopmental outpatient service at Hospital de Clínicas de Porto Alegre, Brazil. Intracranial hemorrhage was significantly associated with multiparity (p=0.02). The neurodevelopmental examination at 6 months' corrected age revealed that patients who suffered neonatal intracranial hemorrhage and/or seizures had inappropriate muscle tone, strength and reflexes, as well as delay in head control. Conclusion: we compared the results of neurodevelopmental examinations of two groups of premature infants at 6 months' corrected age. The difference in neurological development at 6 months' corrected age was statistically significant when comparison was corrected for premature infants who had neonatal seizures and periventricular hemorrhage.

scholarly journals Thyroid hormones and fetal neurological development

2011 ◽  
Vol 209 (1) ◽  
pp. 1-8 ◽  
Author(s):  
J Patel ◽  
K Landers ◽  
H Li ◽  
R H Mortimer ◽  
K Richard
Keyword(s):  
Thyroid Hormone ◽  
Cell Membrane ◽  
Hormone Receptors ◽  
Developmental Stages ◽  
Fetal Brain ◽  
Neurological Development ◽  
Thyroid Hormone Metabolism ◽  
Pituitary Thyroid Axis ◽  
Fetal Thyroid ◽  
Type 3

The development of fetal thyroid function is dependent on the embryogenesis, differentiation, and maturation of the thyroid gland. This is coupled with evolution of the hypothalamic–pituitary–thyroid axis and thyroid hormone metabolism, resulting in the regulation of thyroid hormone action, production, and secretion. Throughout gestation there is a steady supply of maternal thyroxine (T4) which has been observed in embryonic circulation as early as 4 weeks post-implantation. This is essential for normal early fetal neurogenesis. Triiodothyronine concentrations remain very low during gestation due to metabolism via placental and fetal deiodinase type 3. T4 concentrations are highly regulated to maintain low concentrations, essential for protecting the fetus and reaching key neurological sites such as the cerebral cortex at specific developmental stages. There are many known cell membrane thyroid hormone transporters in fetal brain that play an essential role in regulating thyroid hormone concentrations in key structures. They also provide the route for intracellular thyroid hormone interaction with associated thyroid hormone receptors, which activate their action. There is a growing body of experimental evidence from rats and humans to suggest that even mild maternal hypothyroxinemia may lead to abnormalities in fetal neurological development. Our review will focus on the ontogeny of thyroid hormone in fetal development, with a focus on cell membrane transporters and TR action in the brain.

scholarly journals 42 NEUROLOGICAL DEVELOPMENT AT AGE 7–10: SIGNIFICANCE OF CHRONOLOGICAL AGE, HANDEDNSS, SEX, PREMATURITY AND CEREBRAL PALSY

1991 ◽  
Vol 30 (6) ◽  
pp. 635-635
Author(s):  
Remo H Largo ◽  
Markus Riederer ◽  
Luciano Molinari ◽  
Gabriel Duc
Keyword(s):  
Cerebral Palsy ◽  
Chronological Age ◽  
Neurological Development

scholarly journals Neurological Development and Iron Supplementation in Healthy Late-Preterm Neonates: A Randomized Double-Blind Controlled Trial

2021 ◽  
Author(s):  
Rita Luciano ◽  
Domenico Marco Romeo ◽  
Giuseppina Mancini ◽  
Serena Sivo ◽  
Carolina Dolci ◽  
...  
Keyword(s):  
Placebo Group ◽  
Iron Supplementation ◽  
Controlled Trial ◽  
Preterm Neonates ◽  
Neurological Development ◽  
Double Blind ◽  
Neurological Outcomes ◽  
Increased Risk ◽  
The Mean

Abstract ObjectiveLate-preterm infants (LPT) are at increased risk for long-term neurodevelopmental sequelaeand iron deficiency. Aim of the study is to assess the positive effect of iron supplementation on neurological development in healthy LPT.DesignWe designed a perspective, randomized placebo-controlled double-blind trial. The newborns were randomized in two groups: thirty-three patients received martial prophylaxis, thirty-three placebo. Every patient was assessed using the Griffith Mental Development Scales (GMDS)-II edition at 12 months of post-conceptional age.SettingThe study was performed at the Neonatology Unit of Fondazione Policlinico Gemelli IRCCS.PatientsSixty-six healthy LPT infants born between 340⁄7 and 366⁄7 weeks of Gestational Age were enrolled in the study.InterventionsOne group received martial prophylaxis from the third week of life to six months of post-conceptional age (2 mg/kg/day of iron pidolate), the other received placebo.Main outcome measuresFifty-two of the enrolled infants were assessed using the GMDS at 12-month of post-conceptional age. Statistical analysis of the mean scores of the Griffith subscales was performed.ResultsThere was a difference in the mean Developmental Quotient (DQ) (p<0.01) between the two groups: Iron Group mean DQ 121.45+10.53 vs Placebo Group mean DQ 113.25+9.70. Moreover, mean scores of the Griffith subscales A, B and D showed significant differences between the two Groups (scale A p<0.05, scale B p<0.02, scale D p<0.01 respectively).ConclusionsOur data show that newborns who received iron supplementation during the first six months of life achieved significantly better neurological outcomes at GMDS than Placebo group.

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