Neuro-proteomics and Neuro-systems Biology in the Quest of TBI Biomarker Discovery

Author(s):  
Steven Eschrich ◽  
Hongling Zhang ◽  
Haiyan Zhao ◽  
David Boulware ◽  
Ji-Hyun Lee ◽  
...  

Author(s):  
Ali Alawieh ◽  
Zahraa Sabra ◽  
Zhiqun Zhang ◽  
Firas Kobeissy ◽  
Kevin Wang

Metabolites ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 123 ◽  
Author(s):  
Rachel Murphy

The relationship between diet and cancer is often viewed with skepticism by the public and health professionals, despite a considerable body of evidence and general consistency in recommendations over the past decades. A systems biology approach which integrates ‘omics’ data including metabolomics, genetics, metagenomics, transcriptomics and proteomics holds promise for developing a better understanding of how diet affects cancer and for improving the assessment of diet through biomarker discovery thereby renewing confidence in diet–cancer links. This review discusses the application of multi-omics approaches to studies of diet and cancer. Considerations and challenges that need to be addressed to facilitate the investigation of diet–cancer relationships with multi-omic approaches are also discussed.


F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1148 ◽  
Author(s):  
Eli Riekeberg ◽  
Robert Powers

Metabolomics is the newest addition to the “omics” disciplines and has shown rapid growth in its application to human health research because of fundamental advancements in measurement and analysis techniques. Metabolomics has unique and proven advantages in systems biology and biomarker discovery. The next generation of analysis techniques promises even richer and more complete analysis capabilities that will enable earlier clinical diagnosis, drug refinement, and personalized medicine. A review of current advancements in methodologies and statistical analysis that are enhancing and improving the performance of metabolomics is presented along with highlights of some recent successful applications.


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