Interpenetrating Polymer Network Composite Hydrogels and Their Applications in Separation Processes

2014 ◽  
pp. 304-333
Keyword(s):  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Separation Processes ◽  
Composite Hydrogels

Advances in interpenetrating polymer network hydrogels and their applications

2014 ◽  
Vol 86 (11) ◽  
pp. 1707-1721 ◽  
Author(s):  
Ecaterina Stela Dragan
Keyword(s):  
Mechanical Properties ◽  
Drug Loading ◽  
Polymer Network ◽  
Mesh Size ◽  
Ionic Species ◽  
Interpenetrating Polymer Network ◽  
The Novel ◽  
Artificial Cornea ◽  
Separation Processes ◽  
Highly Stretchable

Abstract Interpenetrating polymer network (IPN) hydrogels brought distinct benefits compared to single network hydrogels like more widely controllable physical properties, and (frequently) more efficient drug loading/release. However, IPN strategy is not sufficient to design hydrogels with enhanced mechanical properties required for regenerative medicine like replacement of natural cartilage or artificial cornea. Some of the novel techniques promoted last decade for the preparation of IPN hydrogels which fulfill these requirements are discussed in the review. Among them, “double network” strategy had a strong contribution in the development of a large variety of hydrogels with spectacular mechanical properties at water content up to 90 %. Using cryogelation in tandem with IPN strategy led to composite cryogels with high mechanical properties and high performances in separation processes of ionic species. Highly stretchable and extremely tough hydrogels have been obtained by combining a covalently cross-linked synthetic network with an ionically cross-linked alginate network. IPN hydrogels with tailored mesh size have been also reported.

scholarly journals Porous scaffolds with the structure of an interpenetrating polymer network made by gelatin methacrylated nanoparticle-stabilized high internal phase emulsion polymerization targeted for tissue engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 22544-22555
Author(s):  
Atefeh Safaei-Yaraziz ◽  
Shiva Akbari-Birgani ◽  
Nasser Nikfarjam
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Cell Growth ◽  
Polymer Network ◽  
Synthetic Polymers ◽  
Tissue Scaffolds ◽  
Interpenetrating Polymer Network ◽  
Porous Scaffolds ◽  
Promising Strategy ◽  
Internal Phase

The interlacing of biopolymers and synthetic polymers is a promising strategy to fabricate hydrogel-based tissue scaffolds to biomimic a natural extracellular matrix for cell growth.

scholarly journals Macroporous chitosan/methoxypoly(ethylene glycol) based cryosponges with unique morphology for tissue engineering applications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pradeep Kumar ◽  
Viness Pillay ◽  
Yahya E. Choonara
Keyword(s):  
Tissue Engineering ◽  
Polymer Network ◽  
Three Dimensional ◽  
Hysteresis Loops ◽  
Interpenetrating Polymer Network ◽  
Morphological Data ◽  
Porous Scaffolds ◽  
Morphological Variations ◽  
Molecular Stability ◽  
The Matrix

AbstractThree-dimensional porous scaffolds are widely employed in tissue engineering and regenerative medicine for their ability to carry bioactives and cells; and for their platform properties to allow for bridging-the-gap within an injured tissue. This study describes the effect of various methoxypolyethylene glycol (mPEG) derivatives (mPEG (-OCH3 functionality), mPEG-aldehyde (mPEG-CHO) and mPEG-acetic acid (mPEG-COOH)) on the morphology and physical properties of chemically crosslinked, semi-interpenetrating polymer network (IPN), chitosan (CHT)/mPEG blend cryosponges. Physicochemical and molecular characterization revealed that the –CHO and –COOH functional groups in mPEG derivatives interacted with the –NH2 functionality of the chitosan chain. The distinguishing feature of the cryosponges was their unique morphological features such as fringe thread-, pebble-, curved quartz crystal-, crystal flower-; and canyon-like structures. The morphological data was well corroborated by the image processing data and physisorption curves corresponding to Type II isotherm with open hysteresis loops. Functionalization of mPEG had no evident influence on the macro-mechanical properties of the cryosponges but increased the matrix strength as determined by the rheomechanical analyses. The cryosponges were able to deliver bioactives (dexamethasone and curcumin) over 10 days, showed varied matrix degradation profiles, and supported neuronal cells on the matrix surface. In addition, in silico simulations confirmed the compatibility and molecular stability of the CHT/mPEG blend compositions. In conclusion, the study confirmed that significant morphological variations may be induced by minimal functionalization and crosslinking of biomaterials.

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