Porous Silica Nanoparticles for Drug Delivery and Controlled Release

2014 ◽  
pp. 290-327
Author(s):  
Xiaoxing Sun ◽  
Brian Trewyn
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Silica Nanoparticles ◽  
Porous Silica

scholarly journals Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica nanoparticles for controlled-release drug delivery

2018 ◽  
Vol 340 ◽  
pp. 2-8 ◽  
Author(s):  
Juan L. Paris ◽  
Christophoros Mannaris ◽  
M. Victoria Cabañas ◽  
Robert Carlisle ◽  
Miguel Manzano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Drug

scholarly journals Live-Cell Imaging of Colloidal Mesoporous Silica Nanoparticles for Drug Delivery: Drug Loading, Pore Sealing and Controlled Release

2011 ◽  
Vol 100 (3) ◽  
pp. 600a
Author(s):  
Anna M. Sauer ◽  
Axel Schlossbauer ◽  
Valentina Cauda ◽  
Hanna Engelke ◽  
Christian Argyo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Live Cell ◽  
Pore Sealing

scholarly journals Poly(NIPAM- co -MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system

2017 ◽  
Vol 12 (3) ◽  
pp. 279-284 ◽  
Author(s):  
Sushilkumar A. Jadhav ◽  
Valentina Brunella ◽  
Dominique Scalarone ◽  
Gloria Berlier
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Porous Silica

scholarly journals Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Nikola Ž. Knežević ◽  
Sanja Milenković ◽  
Danica Jović ◽  
Slavica Lazarevic ◽  
Jasminka Mrdjanović ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Thermogravimetric Analysis ◽  
Drug Release ◽  
Silica Nanoparticles ◽  
Porous Silica ◽  
Targeted Treatment ◽  
Capping Agent ◽  
Ph Responsive ◽  
Tumor Tissues ◽  
Acidic Conditions

Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.

A Review on Application of Multifunctional Mesoporous Nanoparticles in Controlled Release of Drug Delivery

2014 ◽  
Vol 781 ◽  
pp. 17-24 ◽  
Author(s):  
Pragnesh N. Dave ◽  
Lakha V. Chopda
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Disease Diagnosis ◽  
Ammonium Bromide ◽  
Composition Material ◽  
Mesoporous Silica Nanoparticle

In the early 1990s the discovery of the MCM-41 and the M41S family of mesoporous materials had open new era in the chemistry and biology. They have prominent application inbiotechnological, biomedical and heterogeneous catalysts. Mesoporous silica nanoparticles (MSNs) exhibit unique structural features like as their large surface areas, tunable pore sizes in nanometer and well-defined surface properties. MSN materials which are comprised of a honeycomb-like porous structure with hundreds of empty mesoporous channel that are able to encapsulate relatively large amounts of biomolecules. They are ideal candidate for constructing multifunctional materials that encapsulate a variety of functional nanostructured materials. Multifunctional MSN materials have become one of the most attractive areas in nanobiotechnology and nanomedicine for various disease diagnosis and therapy. Multifunctional MSN have been successfully developed as a multifunctional platform to deliver therapeutic and diagnostic agents. Multifunctional MSNs are a highly promising platform for intracellular controlled release of drugs. In this review we discuss the recent developments in design and fabrication of multifunctional mesoporous silica nanoparticles in as efficient drug delivery applications such as the site-specific delivery and intracellular controlled release of drugs.Abbreviations;APTES; 3-aminopropyl triethoxy sialne, ATP; Adenosine triphospahate, CD; cyclodextrinCPT; camptothecin, CS; Chitosan,CTAB; cyltrimethylammonium bromide,DNA; Deoxyribonucleic acid,DOX; doxorubicin,EDC; 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide,FD; fluorescein disodium,FSP;Fluroscent particle ,IBU;ibuprofen,MCM; mobil composition material, MPS; 3-trimethoxylsilyl propyl methacrylate, MS; mesoporous silica,MSN; mesoporous silica nanoparticle, MSNs; mesoporous silica nanoparticles,MSNP; mesoporous silica nanoparticle,NPS; nanoparticles;PFDTES;perfluorodecyltriethoxysilane, PAA; polyacrylic acid,PR;photo responsive,PMAA; polymethyl methacrylate,SBF; simulated body fluid,TEOS;tetraethyl orthosilicate,TUNA;Thio undecyl-tetraethyleneglycoestero-nitrobenzylethyldimethyl ammonium bromide.

Thermo-Sensitive Nanogated System Based on Polymer-Modified Mesoporous Silica Hybrid Nanoparticles

2013 ◽  
Vol 538 ◽  
pp. 93-96
Author(s):  
Xin De Tang ◽  
Fa Qi Yu ◽  
Ye Chen ◽  
Mei Shan Pei
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Coupling Reaction ◽  
Solid Support ◽  
Hybrid Nanoparticles ◽  
Chemical Coupling ◽  
External Stimuli

Mesoporous silica nanoparticles (MSNs) have been employed as a versatile solid support for constructing a variety of hybrid materials for controlled drug delivery. Controlled release systems that integrate external stimuli with nanocarriers have attracted much attention for sensors and drug delivery applications. Mesoporous silica nanoparticles grafted with thermo-sensitive polymers on the surface were fabricated via “grafting to” approach through chemical coupling reaction. The encapsulation and release of drug based on the thermo-sensitive nanogated system were investigated. The thermo-sensitive nanogated system can be expected as one of the promising candidates for drug delivery and controlled release.

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