Catalytic Organic Synthesis: A New Paradigm in Industrial Process Intensifi cation

2014 ◽  
pp. 360-405
Keyword(s):  
Organic Synthesis ◽  
Industrial Process ◽  
New Paradigm

CATALYTIC ORGANIC SYNTHESIS: A NEW PARADIGM IN INDUSTRIAL PROCESS INTENSIFICATION

2014 ◽  
pp. 329-374
Author(s):  
Gangavaram Sharma ◽  
Palakodety Krishna ◽  
Venkata Doddi ◽  
Sudhir Kashyap ◽  
Post Reddy
Keyword(s):  
Organic Synthesis ◽  
Industrial Process ◽  
Process Intensification ◽  
New Paradigm

Urea-Catalyzed Functionalization of Unactivated C–H Bonds

2020 ◽  
Author(s):  
Alex L. Bagdasarian ◽  
Stasik Popov ◽  
Benjamin Wigman ◽  
Wenjing Wei ◽  
woojin lee ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Organic Synthesis ◽  
High Energy ◽  
Acid Catalysts ◽  
Potential Utility ◽  
New Paradigm ◽  
Lewis Acid Catalysts ◽  
Reaction Conditions ◽  
Highly Active ◽  
Acidic Nature

Herein we report the 3,5bistrifluoromethylphenyl urea-catalyzed functionalization of unactivated C–H bonds. In this system, the urea catalyst mediates the formation of high-energy vinyl carbocations that undergo facile C–H insertion and Friedel–Crafts reactions. We introduce a new paradigm for these privileged scaffolds where the combination of hydrogen bonding motifs and strong bases affords highly active Lewis acid catalysts capable of ionizing strong C–O bonds. Despite the highly Lewis acidic nature of these catalysts that enables triflate abstraction from sp<sup>2</sup> carbons, these newly found reaction conditions allow for the formation of heterocycles and tolerate highly Lewis basic heteroaromatic substrates. This strategy showcases the potential utility of dicoordinated vinyl carbocations in organic synthesis.<br>

Urea-Catalyzed Functionalization of Unactivated C–H Bonds

2020 ◽  
Author(s):  
Alex L. Bagdasarian ◽  
Stasik Popov ◽  
Benjamin Wigman ◽  
Wenjing Wei ◽  
woojin lee ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Organic Synthesis ◽  
High Energy ◽  
Acid Catalysts ◽  
Potential Utility ◽  
New Paradigm ◽  
Lewis Acid Catalysts ◽  
Reaction Conditions ◽  
Highly Active ◽  
Acidic Nature

Herein we report the 3,5bistrifluoromethylphenyl urea-catalyzed functionalization of unactivated C–H bonds. In this system, the urea catalyst mediates the formation of high-energy vinyl carbocations that undergo facile C–H insertion and Friedel–Crafts reactions. We introduce a new paradigm for these privileged scaffolds where the combination of hydrogen bonding motifs and strong bases affords highly active Lewis acid catalysts capable of ionizing strong C–O bonds. Despite the highly Lewis acidic nature of these catalysts that enables triflate abstraction from sp<sup>2</sup> carbons, these newly found reaction conditions allow for the formation of heterocycles and tolerate highly Lewis basic heteroaromatic substrates. This strategy showcases the potential utility of dicoordinated vinyl carbocations in organic synthesis.<br>

Green Chemistry - A New Paradigm of Organic Synthesis

Synlett ◽  
2010 ◽  
Vol 2010 (13) ◽  
pp. 1988-1989 ◽  
Author(s):  
Yasuhiro Uozumi
Keyword(s):  
Green Chemistry ◽  
Organic Synthesis ◽  
New Paradigm

Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation

2000 ◽  
pp. 3815-4195 ◽  
Author(s):  
Steven V. Ley ◽  
Ian R. Baxendale ◽  
Robert N. Bream ◽  
Philip S. Jackson ◽  
Andrew G. Leach ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
New Paradigm ◽  
Chemical Library

scholarly journals A new paradigm for designing ring construction strategies for green organic synthesis: implications for the discovery of multicomponent reactions to build molecules containing a single ring

2016 ◽  
Vol 12 ◽  
pp. 2420-2442 ◽  
Author(s):  
John Andraos
Keyword(s):  
Organic Synthesis ◽  
Multicomponent Reactions ◽  
Organic Molecules ◽  
New Paradigm ◽  
Chemical Structures ◽  
Novel Synthesis ◽  
Single Ring ◽  
Systematic Enumeration ◽  
Construction Strategies

A new way of developing novel synthesis strategies for the construction of monocyclic rings found in organic molecules is presented. The method is based on the visual application of integer partitioning to chemical structures. Two problems are addressed: (1) the determination of the total number of possible ways to construct a given ring by 2-, 3-, and 4-component couplings; and (2) the systematic enumeration of those possibilities. The results of the method are illustrated using cyclohexanone, pyrazole, and the Biginelli adduct as target ring systems with a view to discover new and greener strategies for their construction using multicomponent reactions. The application of the method is also extended to various heterocycles found in many natural products and pharmaceuticals.

scholarly journals Diversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis

Catalysts ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1328
Author(s):  
Sahil Verma ◽  
Rahul Narayanlal Choudhary ◽  
Akash Prakash Kanadje ◽  
Uttam Chand Banerjee
Keyword(s):  
Pharmaceutical Industry ◽  
Genetic Engineering ◽  
Organic Synthesis ◽  
Process Development ◽  
Industrial Process ◽  
Cascade Reactions ◽  
Third Wave ◽  
Catalytic Systems ◽  
Industrial Utilization ◽  
Drug Synthesis

Hydrolases, being most prominent enzymes used in industrial processes have left no stone unturned in fascinating the pharmaceutical industry. Lipases, being a part of acyl hydrolases are the ones that function similarly to esterases (except an interfacial action) wherein they generally catalyze the hydrolysis of ester bonds. Be it in terms of stereoselectivity or regioselectivity, lipases have manifested their promiscuous proficiency in rendering biocatalytic drug synthesis and intermediates thereof. Industrial utilization of lipases is prevalent since decades ago, but their distinctive catalytic competencies have rendered them suitable for maneuverability in various tides of biocatalytic industrial process development. Numbers of exquisite catalysts have been fabricated out of lipases using nanobiotechnology whereby enzyme reusability and robustness have been conferred to many of the organic synthesis procedures. This marks a considerable achievement of lipases in the second wave of biocatalysis. Furthermore, in the third wave an advent of genetic engineering has fostered an era of customized lipases for suitable needs. Be it stability or an enhanced efficacy, genetic engineering techniques have ushered an avenue for biocatalytic development of drugs and drug intermediates through greener processes using lipases. Even in the forthcoming concept of co-modular catalytic systems, lipases may be the frontiers because of their astonishing capability to act along with other enzymes. The concept may render feasibility in the development of cascade reactions in organic synthesis. An upcoming wave demands fulfilling the vision of tailored lipase whilst a far-flung exploration needs to be unveiled for various research impediments in rendering lipase as a custom fit biocatalyst in pharmaceutical industry.

Solar Filaments as Tracers of Subsurface Processes

2000 ◽  
Vol 179 ◽  
pp. 177-183
Author(s):  
D. M. Rust
Keyword(s):  
Magnetic Fields ◽  
Magnetic Flux ◽  
Coronal Mass Ejections ◽  
Interplanetary Space ◽  
Intermediate Stage ◽  
Coronal Plasma ◽  
Magnetic Helicity ◽  
The Sun ◽  
New Paradigm ◽  
Solar Filaments

AbstractSolar filaments are discussed in terms of two contrasting paradigms. The standard paradigm is that filaments are formed by condensation of coronal plasma into magnetic fields that are twisted or dimpled as a consequence of motions of the fields’ sources in the photosphere. According to a new paradigm, filaments form in rising, twisted flux ropes and are a necessary intermediate stage in the transfer to interplanetary space of dynamo-generated magnetic flux. It is argued that the accumulation of magnetic helicity in filaments and their coronal surroundings leads to filament eruptions and coronal mass ejections. These ejections relieve the Sun of the flux generated by the dynamo and make way for the flux of the next cycle.

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