CATALYTIC ORGANIC SYNTHESIS: A NEW PARADIGM IN INDUSTRIAL PROCESS INTENSIFICATION

2014 ◽  
pp. 329-374
Author(s):  
Gangavaram Sharma ◽  
Palakodety Krishna ◽  
Venkata Doddi ◽  
Sudhir Kashyap ◽  
Post Reddy
Keyword(s):  
Organic Synthesis ◽  
Industrial Process ◽  
Process Intensification ◽  
New Paradigm

Urea-Catalyzed Functionalization of Unactivated C–H Bonds

2020 ◽  
Author(s):  
Alex L. Bagdasarian ◽  
Stasik Popov ◽  
Benjamin Wigman ◽  
Wenjing Wei ◽  
woojin lee ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Organic Synthesis ◽  
High Energy ◽  
Acid Catalysts ◽  
Potential Utility ◽  
New Paradigm ◽  
Lewis Acid Catalysts ◽  
Reaction Conditions ◽  
Highly Active ◽  
Acidic Nature

Herein we report the 3,5bistrifluoromethylphenyl urea-catalyzed functionalization of unactivated C–H bonds. In this system, the urea catalyst mediates the formation of high-energy vinyl carbocations that undergo facile C–H insertion and Friedel–Crafts reactions. We introduce a new paradigm for these privileged scaffolds where the combination of hydrogen bonding motifs and strong bases affords highly active Lewis acid catalysts capable of ionizing strong C–O bonds. Despite the highly Lewis acidic nature of these catalysts that enables triflate abstraction from sp<sup>2</sup> carbons, these newly found reaction conditions allow for the formation of heterocycles and tolerate highly Lewis basic heteroaromatic substrates. This strategy showcases the potential utility of dicoordinated vinyl carbocations in organic synthesis.<br>

Urea-Catalyzed Functionalization of Unactivated C–H Bonds

2020 ◽  
Author(s):  
Alex L. Bagdasarian ◽  
Stasik Popov ◽  
Benjamin Wigman ◽  
Wenjing Wei ◽  
woojin lee ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Organic Synthesis ◽  
High Energy ◽  
Acid Catalysts ◽  
Potential Utility ◽  
New Paradigm ◽  
Lewis Acid Catalysts ◽  
Reaction Conditions ◽  
Highly Active ◽  
Acidic Nature

Herein we report the 3,5bistrifluoromethylphenyl urea-catalyzed functionalization of unactivated C–H bonds. In this system, the urea catalyst mediates the formation of high-energy vinyl carbocations that undergo facile C–H insertion and Friedel–Crafts reactions. We introduce a new paradigm for these privileged scaffolds where the combination of hydrogen bonding motifs and strong bases affords highly active Lewis acid catalysts capable of ionizing strong C–O bonds. Despite the highly Lewis acidic nature of these catalysts that enables triflate abstraction from sp<sup>2</sup> carbons, these newly found reaction conditions allow for the formation of heterocycles and tolerate highly Lewis basic heteroaromatic substrates. This strategy showcases the potential utility of dicoordinated vinyl carbocations in organic synthesis.<br>

Greenhouse gas emissions reduction by process intensification: Reactive distillation column with side decanter

2020 ◽  
pp. 0958305X2093768
Author(s):  
Alexandra-Elena Plesu Popescu ◽  
Jordi Bonet ◽  
Joan Llorens
Keyword(s):  
Chemical Equilibrium ◽  
Carbon Dioxide Emissions ◽  
Distillation Column ◽  
Reactive Distillation ◽  
Industrial Process ◽  
Process Intensification ◽  
Raw Material ◽  
Heat Of Reaction ◽  
The Novel ◽  
Total Reflux

Direct hydration of cyclohexene to produce cyclohexanol is the industrial process with a lower raw material cost but with a quite expensive process. Large energy consumption is consequence of large cyclohexene recycle related with its unfavourable chemical equilibrium. This study corroborates that the Asahi process is a good candidate for intensification avoiding the cyclohexene recycle. Rigorous simulation shows that a single reactive distillation column, with a side decanter, operated at total reflux, allows overcoming the chemical equilibrium limitations as the product is continuously collected by the column bottoms and the heat of reaction is directly used to separate the product by distillation. The novel process is studied and compared to the classical Asahi process. An energy comparison with the available processes proposed in the literature is performed. Therefore, achieving more energy-efficient processes leads to lowering their environmental impact, thus decreasing the carbon dioxide emissions. Applying the proposed methodology for cyclohexanol production, more than 67,000 t CO2/y emissions can be avoided compared to the nowadays used classical process, thus the potential savings applying process intensification to the chemical industry are very large and worth further investigation.

Organic Synthesis Engineering

2001 ◽  
Author(s):  
L. K. Doraiswamy
Keyword(s):  
Organic Synthesis ◽  
Phase Transfer ◽  
Heterogeneous Systems ◽  
Process Intensification ◽  
Reaction Rates ◽  
Main Theme ◽  
Scale Production ◽  
Phase Transfer Catalysts ◽  
Industrial Scale Production

This book will formally launch "organic synthesis engineering" as a distinctive field in the armory of the reaction engineer. Its main theme revolves around two developments: catalysis and the role of process intensification in enhancing overall productivity. Each of these two subjects are becoming increasingly useful in organic synthesis engineering, especially in the production of medium and small volume chemicals and enhancing reaction rates by extending laboratory techniques, such as ultrasound, phase transfer catalysts, membrane reactor, and microwaves, to industrial scale production. This volume describes the applications of catalysis in organic synthesis and outlines different techniques of reaction rate and/or selectivity enhancement against a background of reaction engineering principles for both homogeneous and heterogeneous systems.

Green Chemistry - A New Paradigm of Organic Synthesis

Synlett ◽  
2010 ◽  
Vol 2010 (13) ◽  
pp. 1988-1989 ◽  
Author(s):  
Yasuhiro Uozumi
Keyword(s):  
Green Chemistry ◽  
Organic Synthesis ◽  
New Paradigm

Hybrid membrane operations in water desalination and industrial process rationalisation

2005 ◽  
Vol 51 (6-7) ◽  
pp. 293-304 ◽  
Author(s):  
E. Drioli ◽  
G. Di Profio ◽  
E. Curcio
Keyword(s):  
Industrial Process ◽  
Process Intensification ◽  
Industrial Applications ◽  
Water Desalination ◽  
Raw Material ◽  
Industrial Processes ◽  
Seawater Desalination ◽  
Industrial Growth ◽  
Global Problems ◽  
Membrane Science

Membrane science and technology are recognized today as powerful tools in resolving some important global problems, and developing newer industrial processes, needed from the imperative of sustainable industrial growth. In seawater desalination, for resolving the dramatic increase of freshwater demand in many regions of the world, membrane unitary operations or the combination of some of them in integrated systems are already a real means for producing water from the sea, at lower costs and minimum environmental impact, with a very interesting prospective in particular for poor economy countries. However, membranes are used or are becoming used in some important industrial fields, for developing more efficient productive cycles, with reduced waste of raw-material, reducing the polluting charge by controlling byproduct generation, and reducing overall costs. In the present paper, other than for seawater desalination applications, some industrial applications where membrane technology has led already to match the goal of process intensification are discussed.

Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation

2000 ◽  
pp. 3815-4195 ◽  
Author(s):  
Steven V. Ley ◽  
Ian R. Baxendale ◽  
Robert N. Bream ◽  
Philip S. Jackson ◽  
Andrew G. Leach ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
New Paradigm ◽  
Chemical Library
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