Adverse Effects Associated with Sublingual Immunotherapy

2014 ◽  
pp. 461-468
Author(s):  
Giovanni Passalacqua ◽  
Erkka Valovirta
Keyword(s):  
Adverse Effects ◽  
Sublingual Immunotherapy

Coadministration of Sublingual Immunotherapy Tablets and Management of Potential Adverse Effects: Austrian, German, and Swiss Expert Recommendations

2019 ◽  
Vol 41 (9) ◽  
pp. 1880-1888
Author(s):  
Gunter Johannes Sturm ◽  
Christian Vogelberg ◽  
Miriam Marchon ◽  
Andreas Horn ◽  
Hans-Georg Vitzthum ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Sublingual Immunotherapy ◽  
Expert Recommendations

scholarly journals Rush sublingual immunotherapy in canine atopic dermatitis: a prospective pilot study

2016 ◽  
Vol 19 (1) ◽  
pp. 3-6 ◽  
Author(s):  
M. Fujimura ◽  
H. Ishimaru
Keyword(s):  
Atopic Dermatitis ◽  
Adverse Effects ◽  
Sublingual Immunotherapy ◽  
Pilot Trial ◽  
Maintenance Phase ◽  
Severity Index ◽  
Canine Atopic Dermatitis ◽  
Prospective Pilot Study ◽  
Environmental Allergen ◽  
Allergen Extracts

Abstract Twenty dogs with canine atopic dermatitis (CAD) were treated with rush sublingual immunotherapy (SLIT), with a 48 hour build-up phase and 6 months maintenance phase (treated by antigen once every 3-4 weeks). The canine atopic dermatitis extent and severity index (CADESI)-4 was evaluated before treatment (baseline) and after 6 months. An open, non-controlled, non-randomized pilot trial was conducted to assess the effectiveness and safety of rush SLIT for environmental allergen extracts (Dematophagoides pteronyssinus and D.farinae mix and other). Three dogs dropped out and 17 dogs finished the trial. CADESI-4 at baseline was 60.6±27.1 (range 17-107, n=17). After 6 months of SLIT treatment, CADESI-4 was 37.4±36.0 (range 5-152, n=17) (p <0.01), which was a 38.3% reduction. A significant improvement, defined as a CADESI-4 reduction of > 30%, was observed in 13 out of 17 dogs (76%). A moderate improvement, defined as a CADESI-4 reduction of ≦30%, was observed in 2 dogs (12%). In the other 2 dogs (12%), CADESI-4 worsened or showed no change. However, no severe adverse effects were observed during the trial. Therefore, rush SLIT against environmental allergen extract for CAD showed effectiveness and safety as evidenced by the reduction of CADESI-4 after 6 months SLIT without severe adverse effects.

The Influence of Specimen Thickness in Quantitative Electron Energy Loss Spectroscopy

1980 ◽  
Vol 38 ◽  
pp. 112-113
Author(s):  
Nestor J. Zaluzec
Keyword(s):  
Quantitative Analysis ◽  
Adverse Effects ◽  
Energy Loss ◽  
Electron Energy ◽  
Electron Energy Loss Spectroscopy ◽  
Materials Science ◽  
Light Element ◽  
Specimen Thickness ◽  
Element Analysis ◽  
Electron Energy Loss

The application of electron energy loss spectroscopy (EELS) to light element analysis is rapidly becoming an important aspect of the microcharacterization of solids in materials science, however relatively stringent requirements exist on the specimen thickness under which one can obtain EELS data due to the adverse effects of multiple inelastic scattering.1,2 This study was initiated to determine the limitations on quantitative analysis of EELS data due to specimen thickness.

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