- Engineering Biomimetic Scaffolds

2014 ◽  
pp. 242-281 ◽  
Keyword(s):  
Biomimetic Scaffolds

Biomimetic Design of 3D Printed Tissue-engineered bone Constructs

2020 ◽  
Vol 16 ◽  
Author(s):  
Wei Liu ◽  
Shifeng Liu ◽  
Yunzhe Li ◽  
Peng Zhou ◽  
Qian ma
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Advanced Materials ◽  
Bionic Design ◽  
Material Interfaces ◽  
Precise Control ◽  
Cell Printing ◽  
Biomimetic Scaffolds ◽  
3D Printed

Abstract:: Surgery to repair damaged tissue, which is caused by disease or trauma, is being carried out all the time, and a desirable treatment is compelling need to regenerate damaged tissues to further improve the quality of human health. Therefore, more and more research focus on exploring the most suitable bionic design to enrich available treatment methods. 3D-printing, as an advanced materials processing approach, holds promising potential to create prototypes with complex constructs that could reproduce primitive tissues and organs as much as possible or provide appropriate cell-material interfaces. In a sense, 3D printing promises to bridge between tissue engineering and bionic design, which can provide an unprecedented personalized recapitulation with biomimetic function under the precise control of the composition and spatial distribution of cells and biomaterials. This article describes recent progress in 3D bionic design and the potential application prospect of 3D printing regenerative medicine including 3D printing biomimetic scaffolds and 3D cell printing in tissue engineering.

scholarly journals A biomimetic engineered bone platform for advanced testing of prosthetic implants

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Martina Sladkova-Faure ◽  
Michael Pujari-Palmer ◽  
Caroline Öhman-Mägi ◽  
Alejandro López ◽  
Hanbin Wang ◽  
...  
Keyword(s):  
Calcium Deposition ◽  
Animal Testing ◽  
Scientific Validity ◽  
Matrix Deposition ◽  
Prosthetic Implants ◽  
Gene Expression Matrix ◽  
Biomimetic Scaffolds ◽  
Resolution Imaging ◽  
Preclinical And Clinical Studies

AbstractExisting methods for testing prosthetic implants suffer from critical limitations, creating an urgent need for new strategies that facilitate research and development of implants with enhanced osseointegration potential. Herein, we describe a novel, biomimetic, human bone platform for advanced testing of implants in vitro, and demonstrate the scientific validity and predictive value of this approach using an assortment of complementary evaluation methods. We anchored titanium (Ti) and stainless steel (SS) implants into biomimetic scaffolds, seeded with human induced mesenchymal stem cells, to recapitulate the osseointegration process in vitro. We show distinct patterns of gene expression, matrix deposition, and mineralization in response to the two materials, with Ti implants ultimately resulting in stronger integration strength, as seen in other preclinical and clinical studies. Interestingly, RNAseq analysis reveals that the TGF-beta and the FGF2 pathways are overexpressed in response to Ti implants, while the Wnt, BMP, and IGF pathways are overexpressed in response to SS implants. High-resolution imaging shows significantly increased tissue mineralization and calcium deposition at the tissue-implant interface in response to Ti implants, contributing to a twofold increase in pullout strength compared to SS implants. Our technology creates unprecedented research opportunities towards the design of implants and biomaterials that can be personalized, and exhibit enhanced osseointegration potential, with reduced need for animal testing.

Development and characterisation of microporous biomimetic scaffolds loaded with magnetic nanoparticles as bone repairing material

2020 ◽  
Author(s):  
Florina D. Cojocaru ◽  
Vera Balan ◽  
Constantin-Edi Tanase ◽  
Ionel Marcel Popa ◽  
Maria Butnaru ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomimetic Scaffolds ◽  
Bone Repairing

scholarly journals Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yu Wang ◽  
Shanshan Jin ◽  
Dan Luo ◽  
Danqing He ◽  
Chunyan Shi ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Transcriptional Profiling ◽  
Collagen Scaffold ◽  
Defect Model ◽  
Tendon Regeneration ◽  
Biomimetic Scaffolds ◽  
Functional Regeneration

AbstractTendon injuries disrupt the balance between stability and mobility, causing compromised functions and disabilities. The regeneration of mature, functional tendons remains a clinical challenge. Here, we perform transcriptional profiling of tendon developmental processes to show that the extracellular matrix-associated protein periostin (Postn) contributes to the maintenance of tendon stem/progenitor cell (TSPC) functions and promotes tendon regeneration. We show that recombinant periostin (rPOSTN) promotes the proliferation and stemness of TSPCs, and maintains the tenogenic potentials of TSPCs in vitro. We also find that rPOSTN protects TSPCs against functional impairment during long-term passage in vitro. For in vivo tendon formation, we construct a biomimetic parallel-aligned collagen scaffold to facilitate TSPC tenogenesis. Using a rat full-cut Achilles tendon defect model, we demonstrate that scaffolds loaded with rPOSTN promote endogenous TSPC recruitment, tendon regeneration and repair with native-like hierarchically organized collagen fibers. Moreover, newly regenerated tendons show recovery of mechanical properties and locomotion functions.

scholarly journals Drug-Loaded Biomimetic Ceramics for Tissue Engineering

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 272 ◽  
Author(s):  
Patricia Diaz-Rodriguez ◽  
Mirian Sánchez ◽  
Mariana Landin
Keyword(s):  
Tissue Engineering ◽  
Cell Attachment ◽  
Release Kinetics ◽  
Drug Loading ◽  
Critical Parameters ◽  
Tissue Engineering Scaffolds ◽  
Biomimetic Scaffolds ◽  
Proliferation And Differentiation ◽  
Therapeutic Molecules ◽  
Biological Performance

The mimesis of biological systems has been demonstrated to be an adequate approach to obtain tissue engineering scaffolds able to promote cell attachment, proliferation, and differentiation abilities similar to those of autologous tissues. Bioceramics are commonly used for this purpose due to their similarities to the mineral component of hard tissues as bone. Furthermore, biomimetic scaffolds are frequently loaded with diverse therapeutic molecules to enhance their biological performance, leading to final products with advanced functionalities. In this review, we aim to describe the already developed bioceramic-based biomimetic systems for drug loading and local controlled release. We will discuss the mechanisms used for the inclusion of therapeutic molecules on the designed systems, paying special attention to the identification of critical parameters that modulate drug loading and release kinetics on these scaffolds.

scholarly journals Multiscale fabrication of biomimetic scaffolds for tympanic membrane tissue engineering

2015 ◽  
Vol 7 (2) ◽  
pp. 025005 ◽  
Author(s):  
Carlos Mota ◽  
Serena Danti ◽  
Delfo D’Alessandro ◽  
Luisa Trombi ◽  
Claudio Ricci ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Tympanic Membrane ◽  
Biomimetic Scaffolds

scholarly journals Microfluidic 3D printing polyhydroxyalkanoates-based bionic skin for wound healing

2021 ◽  
Author(s):  
Wentai Guo ◽  
Xiaocheng Wang ◽  
Chaoyu Yang ◽  
Rongkang Huang ◽  
Hui Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
3D Printing ◽  
Umbilical Vein ◽  
Skin Repair ◽  
Biomimetic Scaffolds ◽  
Hierarchical Porous ◽  
Regenerative Activity ◽  
Marrow Mesenchymal Stem Cells ◽  
Umbilical Vein Endothelial Cells

Abstract Biomimetic scaffolds with extracellular matrix (ECM)-mimicking structure have been widely investigated in wound healing applications, while insufficient mechanical strength and limited biological activity remain major challenges. Here, we present a microfluidic 3D printing biomimetic polyhydroxyalkanoates-based scaffold with excellent mechanical properties and hierarchical porous structures for enhanced wound healing. This scaffold is composed of poly(3-hydroxybutyrate-4-hydroxybutyrate) (P34HB) and polycaprolactone (PCL), endowing it with excellent tensile strength (2.99 MPa) and degradability (80% of weight loss within 7 days). The ECM-mimicking hierarchical porous structure allows bone marrow mesenchymal stem cells (BMSCs) and human umbilical vein endothelial cells (HUVECs) to proliferate and adhere on the scaffolds. Besides, anisotropic composite scaffolds loaded with BMSCs and HUVECs can significantly promote re-epithelization, collagen deposition and capillary formation in rat wound defects, indicating their satisfactory in vivo tissue regenerative activity. These results indicate the feasibility of polyhydroxyalkanoates-based biomimetic scaffolds for skin repair and regeneration, which also provide a promising therapeutic strategy in diverse tissue engineering applications.

scholarly journals Biomimetic Scaffolds for Skeletal Muscle Regeneration

Discoveries ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. e90 ◽  
Author(s):  
Greta D. Mulbauer ◽  
◽  
Howard W.T. Matthew ◽  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
Biomimetic Scaffolds

scholarly journals Strontium-Substituted Hydroxyapatite-Gelatin Biomimetic Scaffolds Modulate Bone Cell Response

2018 ◽  
Vol 18 (7) ◽  
pp. 1800096 ◽  
Author(s):  
Silvia Panzavolta ◽  
Paola Torricelli ◽  
Sonia Casolari ◽  
Annapaola Parrilli ◽  
Milena Fini ◽  
...  
Keyword(s):  
Cell Response ◽  
Bone Cell ◽  
Biomimetic Scaffolds
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