- Chemotherapeutic Engineering: Vitamin E TPGS-Emulsified Nanoparticles of Biodegradable Polymers Realized Sustainable Paclitaxel Chemotherapy for 168 h in vivo

2014 ◽  
pp. 180-195
Keyword(s):  
Vitamin E ◽  
Biodegradable Polymers ◽  
Vitamin E Tpgs ◽  
Chemotherapeutic Engineering

Chemotherapeutic engineering: Vitamin E TPGS-emulsified nanoparticles of biodegradable polymers realized sustainable paclitaxel chemotherapy for 168h in vivo

2007 ◽  
Vol 62 (23) ◽  
pp. 6641-6648 ◽  
Author(s):  
Si-Shen Feng ◽  
Lingyun Zhao ◽  
Zhiping Zhang ◽  
Gajadhar Bhakta ◽  
Khin Yin Win ◽  
...  
Keyword(s):  
Vitamin E ◽  
Biodegradable Polymers ◽  
Vitamin E Tpgs ◽  
Chemotherapeutic Engineering

scholarly journals Garcinol loaded vitamin E TPGS emulsified PLGA nanoparticles: preparation, physicochemical characterization, in vitro and in vivo studies

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Raghuvir H. Gaonkar ◽  
Soumya Ganguly ◽  
Saikat Dewanjee ◽  
Samarendu Sinha ◽  
Amit Gupta ◽  
...  
Keyword(s):  
Vitamin E ◽  
Physicochemical Characterization ◽  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Vitamin E Tpgs

Vitamin E TPGS based nanogel for the skin targeting of high molecular weight anti-fungal drug: development and in vitro and in vivo assessment

RSC Advances ◽  
2015 ◽  
Vol 5 (66) ◽  
pp. 53671-53686 ◽  
Author(s):  
Lakhvir Kaur ◽  
Subheet Kumar Jain ◽  
Kanwaldeep Singh
Keyword(s):  
Molecular Weight ◽  
Vitamin E ◽  
Skin Permeation ◽  
Deposition Potential ◽  
Vitamin E Tpgs ◽  
Skin Targeting ◽  
Anti Fungal ◽  
In Vivo Assessment

Enhanced skin permeation and deposition potential of nanogel containing Vitamin E TPGS.

scholarly journals Kanamycin Sulphate Loaded PLGA-Vitamin-E-TPGS Long Circulating Nanoparticles Using Combined Coating of PEG and Water-Soluble Chitosan

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Sanaul Mustafa ◽  
V. Kusum Devi ◽  
Roopa S. Pai
Keyword(s):  
Vitamin E ◽  
Half Life ◽  
Blood Circulation ◽  
The Body ◽  
Water Soluble ◽  
Controlled Delivery ◽  
Protein Synthesis Inhibitor ◽  
Formulation Development ◽  
Vitamin E Tpgs

Kanamycin sulphate (KS) is a Mycobacterium tuberculosis protein synthesis inhibitor. Due to its intense hydrophilicity, KS is cleared from the body within 8 h. KS has a very short plasma half-life (2.5 h). KS is used in high concentrations to reach the therapeutic levels in plasma, which results in serious nephrotoxicity/ototoxicity. To overcome aforementioned limitations, the current study aimed to develop KS loaded PLGA-Vitamin-E-TPGS nanoparticles (KS-PLGA-TPGS NPs), to act as an efficient carrier for controlled delivery of KS. To achieve a substantial extension in blood circulation, a combined design, affixation of polyethylene glycol (PEG) to KS-PLGA-TPGS NPs and adsorption of water-soluble chitosan (WSC) (cationic deacetylated chitin) to particle surface, was raised for surface modification of NPs. Surface modified NPs (KS-PEG-WSC NPs) were prepared to provide controlled delivery and circulate in the bloodstream for an extended period of time, thus minimizing dosing frequency. In vivo pharmacokinetics and in vivo biodistribution following intramuscular administration were investigated. NPs surface charge was close to neutral +3.61 mV and significantly affected by the WSC coating. KS-PEG-WSC NPs presented striking prolongation in blood circulation, reduced protein binding, and long drew-out the blood circulation half-life with resultant reduced kidney sequestration vis-à-vis KS-PLGA-TPGS NPs. The studies, therefore, indicate the successful formulation development of KS-PEG-WSC NPs with reduced frequency of dosing of KS indicating low incidence of nephrotoxicity/ototoxicity.

Preparation and in vivo/in vitro evaluation of formononetin phospholipid/vitamin E TPGS micelles

2015 ◽  
Vol 24 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Xudong Cheng ◽  
Hongmei Yan ◽  
Xiaobin Jia ◽  
Zhenhai Zhang
Keyword(s):  
Vitamin E ◽  
In Vitro Evaluation ◽  
Vitamin E Tpgs
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