Vitamin E TPGS based nanogel for the skin targeting of high molecular weight anti-fungal drug: development and in vitro and in vivo assessment

RSC Advances ◽  
2015 ◽  
Vol 5 (66) ◽  
pp. 53671-53686 ◽  
Author(s):  
Lakhvir Kaur ◽  
Subheet Kumar Jain ◽  
Kanwaldeep Singh
Keyword(s):  
Molecular Weight ◽  
Vitamin E ◽  
Skin Permeation ◽  
Deposition Potential ◽  
Vitamin E Tpgs ◽  
Skin Targeting ◽  
Anti Fungal ◽  
In Vivo Assessment

Enhanced skin permeation and deposition potential of nanogel containing Vitamin E TPGS.

scholarly journals Liquid crystalline systems containing Vitamin E TPGS for the controlled transdermal nicotine delivery

2016 ◽  
Vol 52 (1) ◽  
pp. 191-200 ◽  
Author(s):  
Lívia Neves Borgheti-Cardoso ◽  
Fabiana Testa Moura de Carvalho Vicentini ◽  
Tais Gratieri ◽  
Maria Vitória Lopes Badra Bentley
Keyword(s):  
Vitamin E ◽  
Liquid Crystalline ◽  
Visual Analysis ◽  
Skin Permeation ◽  
Skin Irritation ◽  
Cubic Phase ◽  
Nicotine Delivery ◽  
Vitamin E Tpgs ◽  
Transdermal Nicotine

ABSTRACT Transdermal nicotine patches have been used in smoking cessation therapy, suggested for the treatment of skin disorders with eosinophilic infiltration and have been found to improve attention performance in patients with Alzheimer's disease and age-associated memory impairment. However, skin irritation with extended patch use is still a problem. The aim of this work was to develop a simple to prepare liquid crystalline system containing vitamin E TPGS that would be able to control nicotine delivery and reduce irritation and sensitization problems. The liquid crystalline phases were macroscopically characterized by visual analysis and examined microscopically under a polarized light microscope. Topical and transdermal delivery of nicotine were investigated in vitro using porcine ear skin mounted on a Franz diffusion cell. Nicotine skin permeation from the developed cubic phase followed zero-order kinetics (r = 0.993) and was significantly enhanced after 12 h when compared to the control formulation (nicotine solution) (p < 0.05) (138.86 ± 20.44 and 64.91 ± 4.06 μg/cm2, respectively). Cubic phase was also able to target viable skin layers in comparison to control solution (8.18 ± 1.89 and 2.63 ± 2.51 μg/cm2, respectively). Further studies to evaluate skin sensitization and irritation are now necessary.

Enhanced skin permeation and hydration by magnetic field array: preliminary in-vitro and in-vivo assessment

2010 ◽  
Vol 62 (6) ◽  
pp. 696-701 ◽  
Author(s):  
Heather A.E. Benson ◽  
Gayathri Krishnan ◽  
Jeffrey Edwards ◽  
Yih Miin Liew ◽  
Vincent P. Wallace
Keyword(s):  
Magnetic Field ◽  
Skin Permeation ◽  
In Vivo Assessment

scholarly journals Garcinol loaded vitamin E TPGS emulsified PLGA nanoparticles: preparation, physicochemical characterization, in vitro and in vivo studies

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Raghuvir H. Gaonkar ◽  
Soumya Ganguly ◽  
Saikat Dewanjee ◽  
Samarendu Sinha ◽  
Amit Gupta ◽  
...  
Keyword(s):  
Vitamin E ◽  
Physicochemical Characterization ◽  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Vitamin E Tpgs

Preparation and in vivo/in vitro evaluation of formononetin phospholipid/vitamin E TPGS micelles

2015 ◽  
Vol 24 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Xudong Cheng ◽  
Hongmei Yan ◽  
Xiaobin Jia ◽  
Zhenhai Zhang
Keyword(s):  
Vitamin E ◽  
In Vitro Evaluation ◽  
Vitamin E Tpgs
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