RNA Nanotechnology for Diagnostic Applications

Aspiration cytology and transmission electron microscopy (TEM): A novel tissue-collection technique with useful diagnostic applications

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100110751 ◽

1984 ◽

Vol 42 ◽

pp. 90-93

Author(s):

J.A. Maksem ◽

C. VanDyke ◽

H.W. Carter ◽

C.F. Galang

Keyword(s):

Electron Microscopy ◽

Transmission Electron Microscopy ◽

Diagnostic Technique ◽

Needle Aspiration ◽

Large Series ◽

Aspiration Cytology ◽

Fine Needle ◽

Transmission Electron ◽

Diagnostic Applications ◽

Microscopic Slide

In the last decade fine needle aspiraration biopsy has gained recognition as a valuable diagnostic technique, and its benefits have been demonstrated in large series of patients with almost every type of tumor (1,2). The usual way to collect cellular material from needle-aspiration biopsies is to discharge the needle and syringe contents onto a microscopic slide and smear the material with another slide. The entire specimen is contained on the slides prepared at the time of biopsy. Serious technical difficulties are inherent to this method. 1) Inconsistent fixation, 2) drying artifact, 3) loss of tissue fragments, 4) inability to confirm impressions by a “second method”, and 5) retention of significant diagnostic material in the needle hub. Our technique avoids these difficulties.

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Potential novel diagnostic applications of laser ablation inductively coupled plasma mass spectrometry in trace metal imaging of hepatic metal disorders

Zeitschrift für Gastroenterologie ◽

10.1055/s-0033-1360941 ◽

2014 ◽

Vol 52 (01) ◽

Author(s):

R Weiskirchen ◽

R Uerlings ◽

A Zimmermann ◽

JS Becker

Keyword(s):

Mass Spectrometry ◽

Laser Ablation ◽

Trace Metal ◽

Inductively Coupled Plasma ◽

Inductively Coupled ◽

Plasma Mass Spectrometry ◽

Diagnostic Applications

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Faculty Opinions recommendation of The Future of Boron in Medicinal Chemistry: Therapeutic and Diagnostic Applications.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725225805.793501256 ◽

2014 ◽

Author(s):

Peter R Bernstein

Keyword(s):

Medicinal Chemistry ◽

The Future ◽

Diagnostic Applications

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Dendrimer-Modified Solid Supports: Nanostructured Materials with Potential Drug Allergy Diagnostic Applications

Current Medicinal Chemistry ◽

10.2174/0929867311209024942 ◽

2012 ◽

Vol 19 (29) ◽

pp. 4942-4954 ◽

Cited By ~ 18

Author(s):

A. J. Ruiz-Sanchez ◽

M. I. Montanez ◽

C. Mayorga ◽

M. J. Torres ◽

N. S. Kehr ◽

...

Keyword(s):

Nanostructured Materials ◽

Drug Allergy ◽

Potential Drug ◽

Solid Supports ◽

Diagnostic Applications

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Trends in Diagnosis for Active Tuberculosis Using Nanomaterials

Current Medicinal Chemistry ◽

10.2174/0929867325666180912105617 ◽

2019 ◽

Vol 26 (11) ◽

pp. 1946-1959 ◽

Cited By ~ 3

Author(s):

Le Minh Tu Phan ◽

Lemma Teshome Tufa ◽

Hwa-Jung Kim ◽

Jaebeom Lee ◽

Tae Jung Park

Keyword(s):

Sensitivity And Specificity ◽

High Efficiency ◽

Point Of Care ◽

High Sensitivity ◽

Signs And Symptoms ◽

Diagnostic Methods ◽

Advantages And Disadvantages ◽

Treatment And Prevention ◽

Clinical Tools ◽

Diagnostic Applications

Background:Tuberculosis (TB), one of the leading causes of death worldwide, is difficult to diagnose based only on signs and symptoms. Methods for TB detection are continuously being researched to design novel effective clinical tools for the diagnosis of TB.Objective:This article reviews the methods to diagnose TB at the latent and active stages and to recognize prospective TB diagnostic methods based on nanomaterials.Methods:The current methods for TB diagnosis were reviewed by evaluating their advantages and disadvantages. Furthermore, the trends in TB detection using nanomaterials were discussed regarding their performance capacity for clinical diagnostic applications.Results:Current methods such as microscopy, culture, and tuberculin skin test are still being employed to diagnose TB, however, a highly sensitive point of care tool without false results is still needed. The utilization of nanomaterials to detect the specific TB biomarkers with high sensitivity and specificity can provide a possible strategy to rapidly diagnose TB. Although it is challenging for nanodiagnostic platforms to be assessed in clinical trials, active TB diagnosis using nanomaterials is highly expected to achieve clinical significance for regular application. In addition, aspects and future directions in developing the high-efficiency tools to diagnose active TB using advanced nanomaterials are expounded.Conclusion:This review suggests that nanomaterials have high potential as rapid, costeffective tools to enhance the diagnostic sensitivity and specificity for the accurate diagnosis, treatment, and prevention of TB. Hence, portable nanobiosensors can be alternative effective tests to be exploited globally after clinical trial execution.

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