The Modulation of Skeletal Stem Cell Function Through Nanoscale Topography

2013 ◽  
pp. 125-144
Author(s):  
Manus Biggs ◽  
Laura McNamara
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Nanoscale Topography ◽  
Skeletal Stem Cell

Cell Intrinsic versus Extrinsic Factors and their Role in Skeletal Stem Cell Function with Aging

2014 ◽  
Vol 186 (2) ◽  
pp. 689
Author(s):  
A. McArdle ◽  
C.K. Chan ◽  
D.D. Lo ◽  
M.T. Chung ◽  
K. Senarath-Yapa ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Extrinsic Factors ◽  
Skeletal Stem Cell

The osteoarthritic niche and modulation of skeletal stem cell function for regenerative medicine

2012 ◽  
Vol 7 (8) ◽  
pp. 589-608 ◽  
Author(s):  
E. L. Williams ◽  
C. J. Edwards ◽  
C. Cooper ◽  
R. O. C. Oreffo
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Function ◽  
Skeletal Stem Cell

Developmental Biology I: Bone Development, Repair, and Regeneration

2019 ◽  
Author(s):  
Mimi R. Borrelli ◽  
Ledibabari M. Ngaage ◽  
Derrick C. Wan ◽  
Michael T. Longaker ◽  
H. Peter Lorenz
Keyword(s):  
Stem Cell ◽  
Distraction Osteogenesis ◽  
Endochondral Ossification ◽  
Cell Function ◽  
Bone Development ◽  
Fracture Repair ◽  
Appendicular Skeleton ◽  
Craniofacial Skeleton ◽  
Biology I ◽  
Skeletal Stem Cell

Defects of the skeletal system are extremely common and amount to a significant biomedical burden. Bone is a unique tissue that retains its regenerative potential into adulthood. The biology behind bone development, repair, and regeneration is thus of considerable interest, and may lead to advances in patient care. There are two distinct forms of osteogenesis; bones of the craniofacial skeleton develop via intramembranous ossification, whilst bones of the appendicular skeleton form by endochondral ossification. In this review, bone regenerative mechanisms based on skeletal stem cell function during fracture repair and during distraction osteogenesis are reviewed.  Skeletal stem cell function more closely follows developmental mechanisms during distraction osteogenesis compared to fracture osteogenesis.  This review contains 5 figures and 50 references. Keywords: skeletal stem cell, osteogenesis, skeletogenesis, mechanotransduction, regeneration, remodeling, focal adhesion kinase, ossification

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