Formulation of Metered Dose Inhalers

1997 ◽  
pp. 9-68 ◽  
Author(s):  
T Purewal
Keyword(s):  
Metered Dose Inhalers ◽  
Metered Dose

Metered-Dose Inhalers: Mouth Open or Closed?-Reply

JAMA ◽  
1994 ◽  
Vol 271 (4) ◽  
pp. 272
Author(s):  
Michael J. Tidd
Keyword(s):  
Metered Dose Inhalers ◽  
Metered Dose

scholarly journals Numerical and Experimental Investigation on Key Parameters of the Respimat® Spray Inhaler

Processes ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 44
Author(s):  
Yi Ge ◽  
Zhenbo Tong ◽  
Renjie Li ◽  
Fen Huang ◽  
Jiaqi Yu
Keyword(s):  
High Speed ◽  
Fine Particles ◽  
Geometric Parameters ◽  
Metered Dose Inhalers ◽  
Geometric Pattern ◽  
Long Duration ◽  
Metered Dose ◽  
New Type ◽  
Computational Fluid Dynamics Cfd ◽  
Spray Velocity

Respimat®Soft MistTM is a newly developed spray inhaler. Different from traditional nebulizers, metered-dose inhalers, and dry powder inhalers, this new type of inhaler can produce aerosols with long duration, relatively slow speed, and a high content of fine particles. Investigating the effect of the key geometric parameters of the device on the atomization is of great significance for generic product development and inhaler optimization. In this paper, a laser high-speed camera experimental platform is built, and important parameters such as the geometric pattern and particle size distribution of the Respimat®Soft MistTM are measured. Computational fluid dynamics (CFD) and the volume of fluid method coupled with the Shear Stress Transport (SST) k-ω turbulence model are applied to simulate the key geometric parameters of the device. The effects of geometric parameters on the spray velocity distribution and geometric pattern are obtained. The angle of flow collision, the sphere size of the central divider and the length and width of the flow channel show significant impacts on the spray atomization.

METERED-DOSE INHALERS: DO HEALTH CARE PROVIDERS KNOW WHAT TO TEACH?

PEDIATRICS ◽  
1994 ◽  
Vol 94 (2) ◽  
pp. 260-260
Author(s):  
Allen A. Adinoff
Keyword(s):  
Health Care ◽  
Health Care Providers ◽  
Outpatient Setting ◽  
Large Percentage ◽  
Respiratory Care ◽  
Care Providers ◽  
Metered Dose Inhalers ◽  
Metered Dose

This study confirms that a large percentage of patients use MDI improperly. It also demonstrates a significant lack of understanding by health care providers of the proper use of MDI. Furthermore, this study supports the use of respiratory care practitioners in the outpatient setting, since they were the most proficient among all the health care providers in the proper use of MDI.

scholarly journals Newer Effective Treatment for Adult Acute Asthmatics with a Multi-Dose Regimen of Ipratropium Bromide Plus Salbutamol Using Metered Dose Inhalers with a Spacer Device in Emergency Department

2013 ◽  
Vol 30 (4) ◽  
pp. 195-200
Author(s):  
Md. Mamunur Rashid ◽  
Mohammad Murtaza Khair ◽  
Md. Ali Hossain ◽  
Md. Rashidul Hassan
Keyword(s):  
Emergency Department ◽  
Effective Treatment ◽  
Dose Regimen ◽  
Ipratropium Bromide ◽  
Metered Dose Inhalers ◽  
Metered Dose

J Bangladesh Coll Phys Surg 2012; 30: 195-200 DOI: http://dx.doi.org/10.3329/jbcps.v30i4.14761

scholarly journals NANO-VESICLES OF SALBUTAMOL SULPHATE IN METERED DOSE INHALERS: FORMULATION, CHARACTERIZATION AND IN VITRO EVALUATION

2017 ◽  
Vol 9 (6) ◽  
pp. 100 ◽  
Author(s):  
Mona G. Arafa ◽  
Bassam M. Ayoub
Keyword(s):  
In Vitro Release ◽  
Pulmonary Delivery ◽  
Entrapment Efficiency ◽  
Reversed Phase ◽  
Molar Ratio ◽  
Metered Dose Inhalers ◽  
Salbutamol Sulphate ◽  
Novel Approach ◽  
Metered Dose

Objective: The present work was aimed to prepare niosomes entrapping salbutamol sulphate (SS) using reversed phase evaporation method (REV).Methods: Niosomes were prepared by mixing span 60 and cholesterol in 1:1 molar ratio in chloroform, SS in water was then added to organic phase to form niosomal SS. Formulations after evaporation of chloroform, freeze centrifuged then lyophilized, were evaluated for particles size, polydispersity index (Pdi), zeta-potential, morphology, entrapment efficiency (EE%) and in vitro release. For pulmonary delivery; metered dose inhalers (MDI) were prepared by suspending SS niosomes equivalent to 20 mg SS in hydrofluoroalkane (HFA). The metered valve was investigated for leakage rate, the total number of puffs/canister, weight/puff, dose uniformity and particle size.Results: The results showed spherical niosomes with 400-451 nm particles that entrapped 66.19% of SS. 76.54±0.132% SS release from niosomes that showed a controlled release profile for 8h. The leakage test was not exceeding 4 mg/3 d, the number of puffs were up to 200puffs/canister, the dose delivered/puff was 0.1 mg and 0.64-4.51μm niosomal aerosol.Conclusion: The results indicate an encouraging strategy to formulate a controlled drug delivery by entrapping (SS) in niosomes which could be packaged into (MDI) that met the requirements of (USP) aerosols guidelines which offering a novel approach to respiratory delivery.

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