Orally Induced Tolerance to Nickel: The Role of Oral Exposure (Orthodontic Devices) in Preventing Sensitization

2002 ◽  
pp. 201-216
Keyword(s):  
Oral Exposure ◽  
Induced Tolerance ◽  
Orthodontic Devices

scholarly journals Protective Role of Flavonoids against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6610
Author(s):  
Ana T. Rufino ◽  
Ana Ramalho ◽  
Adelaide Sousa ◽  
José Miguel P. Ferreira de Oliveira ◽  
Paulo Freitas ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Protective Action ◽  
Cell Types ◽  
Protective Role ◽  
Toxic Effects ◽  
Oral Exposure ◽  
Dietary Flavonoids ◽  
Harmful Effects ◽  
Human Intestinal Cells

Silver nanoparticles (AgNP) have been increasingly incorporated into food-related and hygiene products for their unique antimicrobial and preservative properties. The consequent oral exposure may then result in unpredicted harmful effects in the gastrointestinal tract (GIT), which should be considered in the risk assessment and risk management of these materials. In the present study, the toxic effects of polyethyleneimine (PEI)-coated AgNP (4 and 19 nm) were evaluated in GIT-relevant cells (Caco-2 cell line as a model of human intestinal cells, and neutrophils as a model of the intestinal inflammatory response). This study also evaluated the putative protective action of dietary flavonoids against such harmful effects. The obtained results showed that AgNP of 4 and 19 nm effectively induced Caco-2 cell death by apoptosis with concomitant production of nitric oxide, irrespective of the size. It was also observed that AgNP induced human neutrophil oxidative burst. Interestingly, some flavonoids, namely quercetin and quercetagetin, prevented the deleterious effects of AgNP in both cell types. Overall, the data of the present study provide a first insight into the promising protective role of flavonoids against the potentially toxic effects of AgNP at the intestinal level.

The Critical Role of Fas-Fas Ligand Interaction in Donor-Specific Transfusion-Induced Tolerance to H-Y Antigen

2004 ◽  
Vol 78 (6) ◽  
pp. 799-806 ◽  
Author(s):  
Ryosuke Minagawa ◽  
Shinji Okano ◽  
Yukihiro Tomita ◽  
Kenji Kishihara ◽  
Hisakata Yamada ◽  
...  
Keyword(s):  
Fas Ligand ◽  
Critical Role ◽  
Ligand Interaction ◽  
Induced Tolerance

scholarly journals Role of adenosine on morphine-induced tolerance and dependennce in rat.

1999 ◽  
Vol 79 ◽  
pp. 240
Author(s):  
Hirohito Shiomi ◽  
Mika Izumitani ◽  
Naomi Masuda ◽  
Toshiyasu Tsujii ◽  
Mikiko Omoto ◽  
...  
Keyword(s):  
Induced Tolerance

Role of suppressor cells in neonatally induced tolerance to transplantable hepatoma 22a

1980 ◽  
Vol 90 (4) ◽  
pp. 1417-1418
Author(s):  
M. F. Nikonova ◽  
I. N. Maiskii ◽  
T. A. Pokrovskaya ◽  
I. V. Demeshina
Keyword(s):  
Suppressor Cells ◽  
Hepatoma 22A ◽  
Induced Tolerance ◽  
Transplantable Hepatoma

REGULATORY ROLE OF NKT CELLS IS MEDIATED BY LY-49 INHIBITORY RECEPTORS IN CYCLOPHOSPHAMIDE (CP)-INDUCED TOLERANCE

2004 ◽  
Vol 78 ◽  
pp. 536
Author(s):  
T Iwai ◽  
Y Tomita ◽  
I Shimizu ◽  
T Kajiwara ◽  
S Okano ◽  
...  
Keyword(s):  
Nkt Cells ◽  
Regulatory Role ◽  
Inhibitory Receptors ◽  
Induced Tolerance

Role of surface charge in bioavailability and biodistribution of tri-block copolymer nanoparticles in rats after oral exposure

2013 ◽  
Vol 2 (3) ◽  
pp. 187 ◽  
Author(s):  
Sourav Bhattacharjee ◽  
Antonius T. M. Marcelis ◽  
Han Zuilhof ◽  
Ruud A. Woutersen ◽  
Ivonne M. C. M. Rietjens ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Surface Charge ◽  
Oral Exposure

scholarly journals Role of the thymus in natural tolerance to an autologous protein antigen.

1989 ◽  
Vol 169 (1) ◽  
pp. 285-290 ◽  
Author(s):  
M Boguniewicz ◽  
G H Sunshine ◽  
Y Borel
Keyword(s):  
The State ◽  
Lymphoid Cells ◽  
Protein Antigen ◽  
Humoral Antibody ◽  
Induced Tolerance ◽  
Natural Tolerance ◽  
Deficient Mice

C5-deficient mice grafted with thymus from C5-sufficient donors and immunized with C5 failed to make humoral antibody to C5, suggesting that the transfer of thymus had induced tolerance. Irradiated C5-deficient hosts repopulated with lymphoid cells from thymectomized C5-deficient mice grafted with C5-sufficient thymus also failed to respond to immunization with C5, thus showing that the state of tolerance can be adoptively transferred. These results demonstrate that natural tolerance to self-protein antigen is "learned" in the thymus.

scholarly journals THE ROLE OF ORTHODONTIC CARE IN THE COMPLEX REHABILITATION OF GLOSSECTOMY PATIENTS

2021 ◽  
Vol 21 ◽  
pp. 42-45
Author(s):  
Yu. P. Mansur ◽  
◽  
D.V. Verstakov ◽  
L.N. Scherbakov ◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Malignant Tumors ◽  
Tongue Cancer ◽  
Vital Functions ◽  
Surgical Methods ◽  
Jaw Abnormalities ◽  
Orthodontic Devices ◽  
Methods Of Treatment

n recent years, Russia has seen an increase in the incidence of malignant tumors of the mouth and throat, including tongue cancer. Surgical methods of treatment of cancer of such localization have a crippling character and inevitably lead to disruption of a number of vital functions, including the development of tooth-jaw deformities, which further deteriorates the quality of life of such patients. Timely prescription of orthodontic devices for prophylactic and therapeutic purposes allows to prevent the development of tooth jaw abnormalities and deformities, as well as to treat the already developed pathology.

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